2. Others Cytoskeleton
  3. Drug Isomer Integrin
  4. (S,R)-Emvistegrast

(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast (HY-177080). (S,R)-Emvistegrast is an integrin α4β7 inhibtor.

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(S,R)-Emvistegrast

(S,R)-Emvistegrast Chemical Structure

CAS No. : 2417307-56-1

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Other Forms of (S,R)-Emvistegrast:

(S,R)-Emvistegrast Related Antibodies

Top Publications Citing Use of Products

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View All Isoforms
αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast (HY-177080). (S,R)-Emvistegrast is an integrin α4β7 inhibtor[1].

IC50 & Target[1]

α4β7

 

In Vitro

(S,R)-Emvistegrast (Compound 360) is a prodrug, and its active ingredient (Compound 356) inhibits integrin α4β7 with an IC50 of 0.05 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S,R)-Emvistegrast Related Antibodies
Molecular Weight

708.66

Formula

C35H32F4N6O6
CAS No.
SMILES

O=C1N(C(N(C2=CN=CC=C21)C)=O)C3=CC=C(C[C@@H](C(OCC)=O)NC(C4=C(C=C(N5[C@H](COCC5)C(F)(F)F)C=C4F)C)=O)C6=C3N=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S,R)-Emvistegrast Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R)-Emvistegrast2417307-56-1(S,R)-GS-1427Drug IsomerIntegrinInhibitorinhibitorinhibit

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