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Cat. No.: HY-177080A

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(S,R)-Emvistegrast

(Synonyms: (S,R)-GS-1427)

(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast (HY-177080). (S,R)-Emvistegrast is an integrin α4β7 inhibtor.

For research use only. We do not sell to patients.

CAS No.: 2417307-56-1
Formula: C₃₅H₃₂F₄N₆O₆
Molecular Weight:708.66

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(S,R)-Emvistegrast Chemical Structure

CAS No.: 2417307-56-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

(S,R)-Emvistegrast ((S,R)-GS-1427) is an isomer of Emvistegrast (HY-177080). (S,R)-Emvistegrast is an integrin α4β7 inhibtor^[1].

IC₅₀ & Target^[1]

α4β7

All Integrin Isoforms :

In Vitro

(S,R)-Emvistegrast (Compound 360) is a prodrug, and its active ingredient (Compound 356) inhibits integrin α4β7 with an IC₅₀ of 0.05 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2417307-56-1
Molecular Weight 708.66
Formula C₃₅H₃₂F₄N₆O₆
SMILES

O=C1N(C(N(C2=CN=CC=C21)C)=O)C3=CC=C(C[C@@H](C(OCC)=O)NC(C4=C(C=C(N5[C@H](COCC5)C(F)(F)F)C=C4F)C)=O)C6=C3N=CC=C6
Synonyms

(S,R)-GS-1427
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Peter A. Blomgren, et al. Quinoline derivatives as alpha4beta7 integrin inhibitors. WO2020092375A1. 2021-04-30

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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(S,R)-Emvistegrast

All Integrin Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

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(S,R)-Emvistegrast Related Classifications

HY-177080A Related Classifications