1. Cytoskeleton
  2. Integrin

TR-14035 

Cat. No.: HY-15770 Purity: 95.78%
Handling Instructions

TR-14035 is a a dual alpha4beta7(IC50=7 nM)/alpha4beta1 (IC50=87 nM) integrin antagonist .

For research use only. We do not sell to patients.
TR-14035 Chemical Structure

TR-14035 Chemical Structure

CAS No. : 232271-19-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 330 In-stock
5 mg USD 300 In-stock
10 mg USD 456 In-stock
50 mg USD 1080 In-stock
100 mg USD 1680 In-stock
200 mg   Get quote  
500 mg   Get quote  

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    TR-14035 purchased from MCE. Usage Cited in: PLoS One. 2016 Feb 3;11(2):e0148333.

    Blockade of cellular adhesion of HEK 293 cells at 10 or 30 nM coated recombinant OPN forms with 1μM antagonistic integrin inhibitors. RGES (black bars) is used as a control peptide. Cilengitide (white bars) inhibits the integrins αVβ3, αVβ5, and α5β1. TR-14035 (hatched bars) inhibits the integrins α4β7 and α4β1. Depicted are the means ± SEM of 3 independent experiments. * indicate signif
    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    TR-14035 is a a dual alpha4beta7(IC50=7 nM)/alpha4beta1 (IC50=87 nM) integrin antagonist . IC50 Value: alpha(4)beta(7)/alpha(4)beta(1)=7/87 nM [1] Target: integrin TR14035 blocked the binding of human alpha(4)beta(7) to an (125)I-MAdCAM-Ig fusion protein with IC(50) values of 0.75 nM. TR14035 blocked binding of human alpha(4)beta(7)-expressing RPMI-8866 cells or murine mesenteric lymph node lymphocytes to MAdCAM-Ig with IC(50) values of 0.1 microM [2]. TR14035 blocked adhesion to HEVs [ED(50) of 0.01-0.1 mpk i.v.]. TR-14035 was taken up by rat and human hepatocytes by an apparently single saturable mechanism with K(m) of 6.7 and 2.1 microM, respectively, and taurocholate and digoxin reduced this uptake [3].

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.1082 mL 10.5412 mL 21.0824 mL
    5 mM 0.4216 mL 2.1082 mL 4.2165 mL
    10 mM 0.2108 mL 1.0541 mL 2.1082 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    474.33

    Formula

    C₂₄H₂₁Cl₂NO₅

    CAS No.

    232271-19-1

    SMILES

    COC1=C(C2=CC=C(C[[email protected]@H](C(O)=O)NC(C3=C(Cl)C=CC=C3Cl)=O)C=C2)C(OC)=CC=C1

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    DMSO:≥ 41 mg/mL

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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    Product Name:
    TR-14035
    Cat. No.:
    HY-15770
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