232271-19-1
232271-19-1
Chemical Structure
TR-14035
- CAS. Nr.: 232271-19-1
- Formula:C24H21Cl2NO5
- Molecular Weight:474.33
IUPAC Name: (S)-2-(2,6-dichlorobenzamido)-3-(2',6'-dimethoxy-[1,1'-biphenyl]-4-yl)propanoic acid
InChIKey: DRSJLVGDSNWQBI-SFHVURJKSA-N
SMILES: COC1=C(C2=CC=C(C[C@@H](C(O)=O)NC(C3=C(Cl)C=CC=C3Cl)=O)C=C2)C(OC)=CC=C1
Biological Activity: TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases[1][2].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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TR-14035 | 99.87% | TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.67
HY-159179α4 integrin receptor antagonist 3 -
Similarity Score 0.67
HY-14951Firategrast -
Similarity Score 0.67
HY-138542RO0270608 -
Similarity Score 0.58
HY-14190Valategrast -
Similarity Score 0.58
HY-14190A(rac)-Valategrast -
Similarity Score 0.57
HY-14189Valategrast hydrochloride -
Similarity Score 0.57
HY-150124AK34c hydrochloride -
Similarity Score 0.57
HY-150124K34c -
Similarity Score 0.54
HY-103363RSB-328437 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66. [Content Brief]
- [2]. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62. [Content Brief]
