1. Cytoskeleton
  2. Integrin
  3. Valategrast

Valategrast (Synonyms: R-411 free base)

Cat. No.: HY-14190
Handling Instructions

Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment.

For research use only. We do not sell to patients.

Valategrast Chemical Structure

Valategrast Chemical Structure

CAS No. : 220847-86-9

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Description

Valategrast (R-411 free base) is a potent and orally active integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].

IC50 & Target

Integrin α4β1; Integrin α4β7[2]

In Vitro

Valategrast contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].

Molecular Weight

604.95

Formula

C₃₀H₃₂Cl₃N₃O₄

CAS No.

220847-86-9

SMILES

O=C(OCCN(CC)CC)[[email protected]](CC1=CC=C(NC(C2=C(Cl)C=CC=C2Cl)=O)C=C1)NC(C3=C(C)C=CC=C3Cl)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ValategrastR-411R411R 411Integrinα4β1α4β7COPDasthmaMIDASanti-inflammatoryInhibitorinhibitorinhibit

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