1. Cytoskeleton
  2. Integrin
  3. K34c

K34c 

Cat. No.: HY-150124
Handling Instructions

K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research.

For research use only. We do not sell to patients.

K34c Chemical Structure

K34c Chemical Structure

CAS No. : 939769-93-4

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Description

K34c is a potent and selective α5β1 integrin antagonist. K34c can be used for glioblastoma research[1].

IC50 & Target[1]

α5β1

 

In Vitro

K34c (20 μM; 24 or 48 h) significantly induces U87MG cells apoptosis in combination with 1 μM Ellipticine (HY-15753)[1].
K34c (20 μM; 48 h) decreases significantly Temozolomide (HY-17364)-induced senescence in cells transfected with control non targeting siRNA without affecting significantly the residual senescence of cells transfected with siRNA specific for p53[1].
K34c (20 μM; 24 h) modulates the p53 pathway.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: U87MG cells
Concentration: 20 μM
Incubation Time: 24 or 48 h
Result: Induced apoptosis, led to a significant increase in apoptotic cell death measured by the population of sub-G1 cells in combination with 1 μM Ellipticine (HY-15753).

Western Blot Analysis[1]

Cell Line: U87MG cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Decreased Ellipticine (HY-15753)- and Temozolomide (HY-17364)-induced activation of p53.
Molecular Weight

447.53

Formula

C26H29N3O4

CAS No.
SMILES

O=C(O)[[email protected]](CC1=CC=C(OCCCNC2=NC=CC=C2)C=C1)NC(C3=C(C)C=CC=C3C)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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K34c
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HY-150124
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