Ellipticine (Synonyms: NSC 71795)

Name: Ellipticine
Brand: MedChemExpress
SKU: HY-15753
Rating: 5.0 (3 reviews)

Cat. No.: HY-15753 Purity: 99.59%: Data Sheet
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Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

For research use only. We do not sell to patients.

Ellipticine Chemical Structure

CAS No. : 519-23-3

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Ellipticine:

Ellipticine hydrochloride In-stock
Ellipticine (Standard) Get quote

3 Publications Citing Use of MCE Ellipticine

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Topoisomerase Topo I Topo II DNA gyrase

Biological Activity
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Purity & Documentation
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Customer Review

Description

Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.

IC₅₀ & Target^[1]

Topoisomerase II

Cellular Effect

Cell Line	Type	Value	Description	References
5637	IC₅₀	0.89 μM Compound: 1, Ellipticine	Cytotoxicity against human 5637 cells after 96 hrs by crystal violet staining Cytotoxicity against human 5637 cells after 96 hrs by crystal violet staining	[PMID: 19481463]
A-427	IC₅₀	0.89 μM Compound: 1, Ellipticine	Cytotoxicity against human A427 cells after 96 hrs by crystal violet staining Cytotoxicity against human A427 cells after 96 hrs by crystal violet staining	[PMID: 19481463]
A-431	GI₅₀	0.65 μM Compound: Ellipticine	Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay	[PMID: 30660826]
A-431	GI₅₀	3.2 μM Compound: Ellipticine	Growth inhibition of human A431 cells after 72 hrs by trypan blue assay Growth inhibition of human A431 cells after 72 hrs by trypan blue assay	[PMID: 24631729]
A-431	IC₅₀	0.47 μM Compound: Ellipticine	Growth inhibition in human A431 cells after 72 hrs by trypan blue assay Growth inhibition in human A431 cells after 72 hrs by trypan blue assay	[PMID: 21216603]
A498	IC₅₀	1.74 μM Compound: Ellipticine	Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34838335]
A549	ED₅₀	1.26 μM Compound: Ellipticine	Cytotoxicity against human A549 cells by SRB method Cytotoxicity against human A549 cells by SRB method	[PMID: 27793565]
A549	ED₅₀	2.37 μM Compound: Ellipticine	Growth inhibition of human A549 cells after 72 hrs by SRB assay Growth inhibition of human A549 cells after 72 hrs by SRB assay	[PMID: 29097170]
A549	GI₅₀	0.41 μM Compound: 1	Tested in vitro for cytotoxicity in A549/ATCC cell lines Tested in vitro for cytotoxicity in A549/ATCC cell lines	[PMID: 8035426]
A549	IC₅₀	0.4 μM Compound: Ellipticine	Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
A549	IC₅₀	0.47 μM Compound: Ellipticine	Cytotoxicity against human A549 cells after 6 days by SRB assay Cytotoxicity against human A549 cells after 6 days by SRB assay	[PMID: 21330015]
A549	IC₅₀	0.85 μM Compound: Ellipticine	Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay	[PMID: 34838335]
A549	IC₅₀	1.1 μM Compound: Ellipticine	Antiproliferative activity against human A549 cells after 3 days by SRB assay Antiproliferative activity against human A549 cells after 3 days by SRB assay	[PMID: 21916433]
A549	IC₅₀	1.16 μM Compound: Ellipticine	Cytotoxicity against human A549 cells assessed as growth inhibition measured by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition measured by SRB assay	[PMID: 34044119]
A549	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay	[PMID: 28755636]
A549	IC₅₀	1.22 μM Compound: Ellipticine	In vitro cytotoxicity against human A549 (lung cancer) cell line. In vitro cytotoxicity against human A549 (lung cancer) cell line.	[PMID: 15177438]
A549	IC₅₀	1.9 μM Compound: Ellipticine	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 21095131]
A549	IC₅₀	1.9 μM Compound: Ellipticine	Cytotoxicity against human A549 cells by MTT assay Cytotoxicity against human A549 cells by MTT assay	[PMID: 21353568]
A549	IC₅₀	1.9 μM Compound: ellipticine	Cytotoxicity against human A549 cells by SRB assay Cytotoxicity against human A549 cells by SRB assay	[PMID: 17498951]
A549	IC₅₀	1.96 μM Compound: Ellipticine	Cytotoxicity against human A549 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
A549	IC₅₀	10 μM Compound: Ellipticine	In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis) In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)	[PMID: 12036369]
A549	IC₅₀	2.07 μM Compound: ellipticine	Cytotoxicity against human A549 cells after 3 days by SRB assay Cytotoxicity against human A549 cells after 3 days by SRB assay	[PMID: 17035025]
A549	IC₅₀	2.13 μM Compound: Ellipticine	Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay	[PMID: 33316411]
A549	IC₅₀	2.25 μM Compound: Ellipticine	Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 32527561]
A549	IC₅₀	3.4 μM Compound: Ellipticine	Cytotoxicity against human A549 cells after 72 hrs by MTT assay Cytotoxicity against human A549 cells after 72 hrs by MTT assay	[PMID: 20667744]
A549	IC₅₀	3.4 μM Compound: Ellipticine	Antitumor activity against human A549 cells after 72 hrs by MTT assay Antitumor activity against human A549 cells after 72 hrs by MTT assay	[PMID: 21458275]
A549	IC₅₀	3.45 μM Compound: Ellipticine	Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay	[PMID: 35219149]
BC	IC₅₀	0.14 μg/mL Compound: Ellipticine	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 16989536]
BC	IC₅₀	0.1 μg/mL Compound: ellipticine	Cytotoxicity against human BC cells by SRB assay Cytotoxicity against human BC cells by SRB assay	[PMID: 11277765]
BC	IC₅₀	0.27 μg/mL Compound: ellipticine	Cytotoxicity against human BC cells by SRB assay Cytotoxicity against human BC cells by SRB assay	[PMID: 16309322]
BC	IC₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against human BC cells Cytotoxicity against human BC cells	[PMID: 12828479]
BC	IC₅₀	0.2 μg/mL Compound: ellipticine	Cytotoxicity against human BC cells by SRB assay Cytotoxicity against human BC cells by SRB assay	[PMID: 15043440]
BC	IC₅₀	0.32 μg/mL Compound: Ellipticine	Cytotoxicity against human BC clls Cytotoxicity against human BC clls	[PMID: 16441071]
BC	IC₅₀	0.36 μg/mL Compound: Ellipticine	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 16038539]
BC	IC₅₀	0.3 μg/mL Compound: ellipticine	Cytotoxicity against human BC cells by colorimetric assay Cytotoxicity against human BC cells by colorimetric assay	[PMID: 16378377]
BC	IC₅₀	0.49 μM Compound: ellipticine	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 18363379]
BC	IC₅₀	0.4 μg/mL Compound: ellipticine	Cytotoxicity against human BC cells Cytotoxicity against human BC cells	[PMID: 15217275]
BC	IC₅₀	0.8 μM Compound: ellipticine	Cytotoxicity against human BC cells Cytotoxicity against human BC cells	[PMID: 16038559]
BC	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human BC cells by SRB assay Cytotoxicity against human BC cells by SRB assay	[PMID: 19265430]
BC	IC₅₀	1.2 μM Compound: ellipticine	Cytotoxicity against human BC cells by colorimetric method Cytotoxicity against human BC cells by colorimetric method	[PMID: 18380478]
BC	IC₅₀	2.7 μM Compound: elliptecine	Cytotoxicity against human BC cells Cytotoxicity against human BC cells	[PMID: 16919455]
BC	IC₅₀	6.1 μM Compound: ellipticine	Cytotoxicity against BC cells by colorimetric method Cytotoxicity against BC cells by colorimetric method	[PMID: 17480099]
BC	IC₅₀	6.82 x 10^-4 M Compound: ellipticine	Cytotoxicity against human BC cells by SRB assay Cytotoxicity against human BC cells by SRB assay	[PMID: 16933890]
Breast carcinoma cell	IC₅₀	0.1 μg/mL Compound: Ellipticine	Cytotoxic concentration of compound against human breast cancer cells Cytotoxic concentration of compound against human breast cancer cells	[PMID: 12729658]
CAKI-1	GI₅₀	1.01 μM Compound: 1	Tested in vitro for cytotoxicity in CAKI-1 cell lines Tested in vitro for cytotoxicity in CAKI-1 cell lines	[PMID: 8035426]
CCRF-CEM	GI₅₀	0.415 μM Compound: 1	Tested in vitro for cytotoxicity in CCRF-CEM cell lines Tested in vitro for cytotoxicity in CCRF-CEM cell lines	[PMID: 8035426]
CHO	IC₅₀	0.0193 μM Compound: 1	Bioactivation in CYP1A1 (unknown origin) transfected CHO cells assessed as CYP1A1-mediated drug activation by measuring reduction in cell viability Bioactivation in CYP1A1 (unknown origin) transfected CHO cells assessed as CYP1A1-mediated drug activation by measuring reduction in cell viability	[PMID: 31675512]
CHO	IC₅₀	0.02 μM Compound: 1	Cytotoxicity against CHO cells assessed as reduction in cell viability Cytotoxicity against CHO cells assessed as reduction in cell viability	[PMID: 31675512]
COLO 205	GI₅₀	0.588 μM Compound: 1	Tested in vitro for cytotoxicity in COLO 205 cell lines Tested in vitro for cytotoxicity in COLO 205 cell lines	[PMID: 8035426]
Cancer cell lines	ED₅₀	2.19 μM Compound: Ellipticine	Cytotoxicity against human colon cancer cells by SRB method Cytotoxicity against human colon cancer cells by SRB method	[PMID: 27793565]
Cancer cell lines	IC₅₀	0.13 μg/mL Compound: ellipticine	Cytotoxicity against human breast cancer cells Cytotoxicity against human breast cancer cells	[PMID: 18179177]
Col2	ED₅₀	0.3 μg/mL Compound: Ellipticine	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 12762797]
Col2	ED₅₀	0.53 μg/mL Compound: Ellipticine	Cytotoxicity against human Col2 cells by SRB assay Cytotoxicity against human Col2 cells by SRB assay	[PMID: 17190450]
Col2	ED₅₀	0.5 μg/mL Compound: Ellipticine	Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay	[PMID: 18271551]
Col2	ED₅₀	2.2 μM Compound: Ellipticine	Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay	[PMID: 23550966]
Col2	ED₅₀	2.72 μM Compound: Ellipt	Cytotoxicity against human Col2 cells by SRB assay Cytotoxicity against human Col2 cells by SRB assay	[PMID: 22154665]
Col2	IC₅₀	1.22 μM Compound: Ellipticine	In vitro cytotoxicity against human Col2 (colon cancer) cell line. In vitro cytotoxicity against human Col2 (colon cancer) cell line.	[PMID: 15177438]
Col2	IC₅₀	1.22 μM Compound: ellipticine	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 14987058]
Col2	IC₅₀	1.82 μM Compound: ellipticine	Cytotoxicity against human Col2 cells after 3 days by SRB assay Cytotoxicity against human Col2 cells after 3 days by SRB assay	[PMID: 17035025]
Col2	IC₅₀	2.3 μM Compound: Ellipticine	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 21095131]
Col2	IC₅₀	2.3 μM Compound: Ellipticine	Cytotoxicity against human Col2 cells by MTT assay Cytotoxicity against human Col2 cells by MTT assay	[PMID: 21353568]
Col2	IC₅₀	2.3 μM Compound: ellipticine	Cytotoxicity against human Col2 cells by SRB assay Cytotoxicity against human Col2 cells by SRB assay	[PMID: 17498951]
DMS-114	GI₅₀	0.552 μM Compound: 1	Tested in vitro for cytotoxicity in DMS114 cell lines Tested in vitro for cytotoxicity in DMS114 cell lines	[PMID: 8035426]
FaDu	IC₅₀	1.85 μM Compound: Ellipticine	Cytotoxicity against human FaDu cells assessed as growth inhibition measured by SRB assay Cytotoxicity against human FaDu cells assessed as growth inhibition measured by SRB assay	[PMID: 34044119]
HCT-116	GI₅₀	0.29 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of colon cancer HCT116 cells Cytotoxic effect on growth inhibition of colon cancer HCT116 cells	[PMID: 8765520]
HCT-116	IC₅₀	0.3 μM Compound: 1, Ellipticine	Growth inhibition of human HCT116 cells by MTT assay Growth inhibition of human HCT116 cells by MTT assay	[PMID: 17376678]
HCT-116	IC₅₀	0.41 μM Compound: Ellipticine	Cytotoxicity against human HCT116 cells after 6 days by SRB assay Cytotoxicity against human HCT116 cells after 6 days by SRB assay	[PMID: 21330015]
HCT-116	IC₅₀	1 μM Compound: Ellipticine	Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
HCT-15	ED₅₀	0.17 μg/mL Compound: ellipticine	Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay	[PMID: 9917280]
HCT-15	ED₅₀	0.24 μg/mL Compound: Ellipticine	Cytotoxicity against human HCT-15 cells after 72 hrs by SRB method Cytotoxicity against human HCT-15 cells after 72 hrs by SRB method	[PMID: 10479311]
HCT-15	GI₅₀	1.91 μM Compound: Ellipticine	Growth inhibition of human HCT15 cells after 48 hrs by SRB assay Growth inhibition of human HCT15 cells after 48 hrs by SRB assay	[PMID: 24121236]
HEK293	ED₅₀	1.9 μM Compound: Ellipticine	Cytotoxicity against human HEK293 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human HEK293 cells after 72 hrs by sulforhodamine B assay	[PMID: 23550966]
HEK293	ED₅₀	2.03 μM Compound: Ellipticine	Cytotoxicity against human HEK293 cells by SRB method Cytotoxicity against human HEK293 cells by SRB method	[PMID: 27793565]
HEK293	ED₅₀	2.27 μM Compound: Ellipticine	Growth inhibition of human HEK293 cells after 72 hrs by SRB assay Growth inhibition of human HEK293 cells after 72 hrs by SRB assay	[PMID: 29097170]
HEK293	IC₅₀	1.69 μM Compound: Ellipticine	Cytotoxicity against human HEK293 cells Cytotoxicity against human HEK293 cells	[PMID: 33556568]
HEK293	IC₅₀	1.9 μM Compound: Ellipticine	Cytotoxicity against HEK293 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against HEK293 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
HEK293	IC₅₀	6.58 μM Compound: Ellipticine	Cytotoxicity against human HEK293 cells assessed as cell viability measured by MTT assay Cytotoxicity against human HEK293 cells assessed as cell viability measured by MTT assay	[PMID: 33895275]
HEp-2	IC₅₀	0.4 μg/mL Compound: Ellipticine	Cytotoxicity against human Hep2 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Hep2 cells after 72 hrs by sulforhodamine B assay	[PMID: 19265396]
HEp-2	IC₅₀	9.85 μM Compound: Ellipticine	Cytotoxicity against human HEp-2 cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human HEp-2 cells assessed as cell growth inhibition by MTT assay	[PMID: 34838335]
HL-60	GI₅₀	2 μM Compound: Ellipticine	Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay	[PMID: 24631729]
HL-60	IC₅₀	0.64 μM Compound: Ellipticine	Growth inhibition in human HL60 cells after 72 hrs by trypan blue assay Growth inhibition in human HL60 cells after 72 hrs by trypan blue assay	[PMID: 21216603]
HL-60	IC₅₀	0.66 μM Compound: Ellipticine	Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay	[PMID: 19155103]
HL-60	IC₅₀	0.66 μM Compound: ellipticine	Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay	[PMID: 19725581]
HL-60	IC₅₀	1.7 μM Compound: Ellipticine	Antiproliferative activity against human HL60 cells by MTT assay Antiproliferative activity against human HL60 cells by MTT assay	[PMID: 31546197]
HL-60	IC₅₀	1.7 μM Compound: Ellipticine	Anticancer activity against human HL-60 cells Anticancer activity against human HL-60 cells	[PMID: 31945642]
HL-60	IC₅₀	2 μM Compound: Ellipticine	Cytotoxicity in human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
HL-60	IC₅₀	2.6 μM Compound: ellipticine	Cytotoxicity against human HL60 cells after 3 days by SRB assay Cytotoxicity against human HL60 cells after 3 days by SRB assay	[PMID: 17035025]
HL-60	IC₅₀	2.93 μM Compound: Ellipticine	Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
HL-60	IC₅₀	5.8 μM Compound: Ellipticine	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 21095131]
HL-60	IC₅₀	5.8 μM Compound: Ellipticine	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 21353568]
HL-60	IC₅₀	5.8 μM Compound: ellipticine	Cytotoxicity against human HL60 cells by MTT assay Cytotoxicity against human HL60 cells by MTT assay	[PMID: 17498951]
HT-1080	IC₅₀	0.21 μM Compound: Ellipticine	Cytotoxicity against human HT1080 cells after 6 days by SRB assay Cytotoxicity against human HT1080 cells after 6 days by SRB assay	[PMID: 21330015]
HT-1080	IC₅₀	4.3 μM Compound: Ellipticine	Cytotoxicity against human HT1080 cells Cytotoxicity against human HT1080 cells	[PMID: 21095131]
HT-1080	IC₅₀	4.3 μM Compound: Ellipticine	Cytotoxicity against human HT1080 cells by MTT assay Cytotoxicity against human HT1080 cells by MTT assay	[PMID: 21353568]
HT-1080	IC₅₀	4.3 μM Compound: ellipticine	Cytotoxicity against human HT1080 cells by SRB assay Cytotoxicity against human HT1080 cells by SRB assay	[PMID: 17498951]
HT-1080	IC₅₀	5.01 μM Compound: ellipticine	Cytotoxicity against human HT1080 cells after 3 days by SRB assay Cytotoxicity against human HT1080 cells after 3 days by SRB assay	[PMID: 17035025]
HT-29	ED₅₀	2.43 μM Compound: Ellipticine	Cytotoxicity against human HT-29 cells by SRB method Cytotoxicity against human HT-29 cells by SRB method	[PMID: 27793565]
HT-29	ED₅₀	2.68 μM Compound: Ellipticine	Growth inhibition of human HT-29 cells after 72 hrs by SRB assay Growth inhibition of human HT-29 cells after 72 hrs by SRB assay	[PMID: 29097170]
HT-29	IC₅₀	1.95 μM Compound: Ellipticine	Cytotoxicity against human HT-29 cells assessed as growth inhibition measured by SRB assay Cytotoxicity against human HT-29 cells assessed as growth inhibition measured by SRB assay	[PMID: 34044119]
HT-29	IC₅₀	14.9 μM Compound: ellipticine	Cytotoxicity against human HT29 cell line Cytotoxicity against human HT29 cell line	[PMID: 17228871]
HT-29	IC₅₀	15 μM Compound: Ellipticine	In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis) In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)	[PMID: 12036369]
HT-29	IC₅₀	2 μM Compound: Ellipticine	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
HT-29	IC₅₀	2.06 μM Compound: Ellipticine	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay	[PMID: 28755636]
HT-29	IC₅₀	2.16 μM Compound: Ellipticine	Anticancer activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Anticancer activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 32527561]
HT-29	IC₅₀	2.59 μM Compound: Ellipticine	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay	[PMID: 33316411]
HUVEC	IC₅₀	0.37 μM Compound: ellipticine	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 14987058]
HeLa	GI₅₀	0.3 μM Compound: Ellipticine	Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay	[PMID: 24631729]
HeLa	GI₅₀	0.47 μM Compound: Ellipticine	Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay	[PMID: 30660826]
HeLa	GI₅₀	3.28 μM Compound: Ellipticine	Growth inhibition of human HeLa cells after 48 hrs by SRB assay Growth inhibition of human HeLa cells after 48 hrs by SRB assay	[PMID: 24121236]
HeLa	IC₅₀	0.29 μM Compound: Ellipticine	Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay	[PMID: 19155103]
HeLa	IC₅₀	0.29 μM Compound: ellipticine	Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay	[PMID: 19725581]
HeLa	IC₅₀	0.31 μM Compound: Ellipticine	Growth inhibition in human HeLa cells after 72 hrs by trypan blue assay Growth inhibition in human HeLa cells after 72 hrs by trypan blue assay	[PMID: 21216603]
HeLa	IC₅₀	0.4 μg/mL Compound: Ellipticine	Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay	[PMID: 19265396]
HeLa	IC₅₀	1 μM Compound: Ellipticine	Cytotoxicity against human HeLa cells assessed as growth inhibition by MTT assay Cytotoxicity against human HeLa cells assessed as growth inhibition by MTT assay	[PMID: 26599533]
HeLa	IC₅₀	1.05 μM Compound: Ellipticine	Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34838335]
HeLa	IC₅₀	1.6 μM Compound: Ellipticine	Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
HeLa	IC₅₀	2 μM Compound: Ellipticine	Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by MTS assay Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by MTS assay	[PMID: 31411887]
HeLa	IC₅₀	9.81 μM Compound: Ellipticine	Cytotoxicity against human HeLa cells after 48 hrs by MTT assay Cytotoxicity against human HeLa cells after 48 hrs by MTT assay	10.1039/C2MD20335A
HeLa	IC₅₀	9.85 μM Compound: Ellipticine	Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay	[PMID: 34838335]
HeLa S3	IC₅₀	2.1 μM Compound: 1	Cytotoxicity against human HeLaS3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLaS3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28063783]
HeLa S3	IC₅₀	2.1 μM Compound: 21	Cytotoxicity against human HeLaS3 cells assessed as cell viability after 24 to 72 hrs by MTT assay Cytotoxicity against human HeLaS3 cells assessed as cell viability after 24 to 72 hrs by MTT assay	[PMID: 24863982]
HepG2	GI₅₀	2.9 μM Compound: Ellipticine	Growth inhibition of human HepG2 cells after 72 hrs by SRB assay Growth inhibition of human HepG2 cells after 72 hrs by SRB assay	[PMID: 22014996]
HepG2	GI₅₀	5.38 μM Compound: Ellipticine	Growth inhibition of human HepG2 cells after 48 hrs by SRB assay Growth inhibition of human HepG2 cells after 48 hrs by SRB assay	[PMID: 24121236]
HepG2	IC₅₀	0.36 μg/mL Compound: Ellipticine	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 26459207]
HepG2	IC₅₀	0.85 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay	[PMID: 32717612]
HepG2	IC₅₀	0.93 μM Compound: Ellipticine	Antiproliferative activity against human HepG2 cells by MTT assay Antiproliferative activity against human HepG2 cells by MTT assay	[PMID: 31546197]
HepG2	IC₅₀	0.93 μM Compound: Ellipticine	Antiproliferative activity against human HepG2 cells Antiproliferative activity against human HepG2 cells	[PMID: 31945642]
HepG2	IC₅₀	1.05 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34838335]
HepG2	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 25442310]
HepG2	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity in human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
HepG2	IC₅₀	1.26 nM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 3 days by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 3 days by MTT assay	[PMID: 24745968]
HepG2	IC₅₀	1.26 nM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human HepG2 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 25442315]
HepG2	IC₅₀	1.3 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 26081288]
HepG2	IC₅₀	1.34 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as cell viability measured by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability measured by MTT assay	[PMID: 33895275]
HepG2	IC₅₀	1.38 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 28512032]
HepG2	IC₅₀	1.46 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as growth inhibition measured after 3 days by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition measured after 3 days by MTT assay	[PMID: 27342752]
HepG2	IC₅₀	1.5 μM Compound: EC	Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay	[PMID: 26516994]
HepG2	IC₅₀	1.66 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells Cytotoxicity against human HepG2 cells	[PMID: 33556568]
HepG2	IC₅₀	1.71 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay	[PMID: 26099533]
HepG2	IC₅₀	1.95 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells after 3 days by MTT assay Cytotoxicity against human HepG2 cells after 3 days by MTT assay	[PMID: 27517802]
HepG2	IC₅₀	2.07 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay	[PMID: 26522953]
HepG2	IC₅₀	2.72 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells after 3 days by MTT assay Cytotoxicity against human HepG2 cells after 3 days by MTT assay	[PMID: 30337229]
HepG2	IC₅₀	2.9 μM Compound: Ellipticine	Cytotoxicity against human HepG2 cells assessed as growth inhibition by MTT assay Cytotoxicity against human HepG2 cells assessed as growth inhibition by MTT assay	[PMID: 26599533]
HepG2	IC₅₀	3.5 μM Compound: Ellipticine	Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Hepatocyte	GI₅₀	3.3 μM Compound: Ellipticine	Growth inhibition of porcine primary hepatocytes after 72 hrs by SRB assay Growth inhibition of porcine primary hepatocytes after 72 hrs by SRB assay	[PMID: 22014996]
HuCC-A1	ED₅₀	3.46 μM Compound: Ellipticine	Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay	[PMID: 29097170]
HuCC-A1	IC₅₀	2.43 μM Compound: Ellipticine	Anticancer activity against human HuCCa1 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Anticancer activity against human HuCCa1 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 32527561]
IGROV-1	GI₅₀	0.86 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of ovarian cancer IGROVI cells Cytotoxic effect on growth inhibition of ovarian cancer IGROVI cells	[PMID: 8765520]
IGROV-1	GI₅₀	0.862 μM Compound: 1	Tested in vitro for cytotoxicity in IGROV1 cell lines Tested in vitro for cytotoxicity in IGROV1 cell lines	[PMID: 8035426]
Ishikawa	IC₅₀	1.05 μM Compound: Ellipticine	Cytotoxicity against human Ishikawa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human Ishikawa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34838335]
Ishikawa	IC₅₀	1.5 μM Compound: Ellipticine	Cytotoxicity against human Ishikawa cells assessed as growth inhibition by MTT assay Cytotoxicity against human Ishikawa cells assessed as growth inhibition by MTT assay	[PMID: 26599533]
K562	IC₅₀	0.38 μM Compound: Ellipticine	Cytotoxicity against human K562 cells after 6 days by SRB assay Cytotoxicity against human K562 cells after 6 days by SRB assay	[PMID: 21330015]
KB	ED₅₀	0.04 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 12762797]
KB	ED₅₀	0.04 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells after 3 days by SRB assay Cytotoxicity against human KB cells after 3 days by SRB assay	[PMID: 7528785]
KB	ED₅₀	0.1 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 9917280]
KB	ED₅₀	0.33 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by SRB method Cytotoxicity against human KB cells after 72 hrs by SRB method	[PMID: 10479311]
KB	ED₅₀	0.36 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 7130986]
KB	ED₅₀	0.65 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 17190450]
KB	ED₅₀	0.7 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 18271551]
KB	ED₅₀	1.31 μg/mL Compound: Ellipticine	Toxicity against human KB cells Toxicity against human KB cells	[PMID: 17067158]
KB	ED₅₀	2.03 μM Compound: Ellipticine	Cytotoxicity against human KB cells by SRB method Cytotoxicity against human KB cells by SRB method	[PMID: 27793565]
KB	ED₅₀	2.2 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 23550966]
KB	ED₅₀	2.34 μM Compound: Ellipticine	Growth inhibition of human KB cells after 72 hrs by SRB assay Growth inhibition of human KB cells after 72 hrs by SRB assay	[PMID: 29097170]
KB	ED₅₀	2.46 μM Compound: Ellipt	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 22154665]
KB	IC₅₀	0.16 μM Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 14987058]
KB	IC₅₀	0.19 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by sulforhodamine B assay Cytotoxicity against human KB cells by sulforhodamine B assay	[PMID: 21341709]
KB	IC₅₀	0.1 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 11277765]
KB	IC₅₀	0.21 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 16989536]
KB	IC₅₀	0.21 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 16309322]
KB	IC₅₀	0.24 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by MTT assay Cytotoxicity against human KB cells by MTT assay	[PMID: 16792425]
KB	IC₅₀	0.26 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 16038539]
KB	IC₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 12828479]
KB	IC₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by sulforhodamine B assay Cytotoxicity against human KB cells by sulforhodamine B assay	[PMID: 19368377]
KB	IC₅₀	0.2 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 15043440]
KB	IC₅₀	0.36 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16441071]
KB	IC₅₀	0.36 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 19663417]
KB	IC₅₀	0.36 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15730240]
KB	IC₅₀	0.36 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 17845001]
KB	IC₅₀	0.36 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 19627125]
KB	IC₅₀	0.37 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by sulforhodamine B assay Cytotoxicity against human KB cells by sulforhodamine B assay	[PMID: 19555123]
KB	IC₅₀	0.3 μg/mL Compound: Ellipticine	Cytotoxicity against KB cell line Cytotoxicity against KB cell line	[PMID: 12657257]
KB	IC₅₀	0.3 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 12350163]
KB	IC₅₀	0.3 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by colorimetric assay Cytotoxicity against human KB cells by colorimetric assay	[PMID: 16378377]
KB	IC₅₀	0.41 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 18179177]
KB	IC₅₀	0.45 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 20329738]
KB	IC₅₀	0.46 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 11520217]
KB	IC₅₀	0.48 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 19778068]
KB	IC₅₀	0.4 μg/mL Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay	[PMID: 19265396]
KB	IC₅₀	0.4 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15217275]
KB	IC₅₀	0.52 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 3 days by MTT assay Cytotoxicity against human KB cells after 3 days by MTT assay	[PMID: 27517802]
KB	IC₅₀	0.67 μg/mL Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 17567069]
KB	IC₅₀	0.8 μM Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16038559]
KB	IC₅₀	0.81 μM Compound: Ellipticine	Antiproliferative activity against human KB cells by MTT assay Antiproliferative activity against human KB cells by MTT assay	[PMID: 31546197]
KB	IC₅₀	0.81 μM Compound: Ellipticine	Antiproliferative activity against human KB cells Antiproliferative activity against human KB cells	[PMID: 31945642]
KB	IC₅₀	1.1 μM Compound: ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 20815366]
KB	IC₅₀	1.19 μM Compound: Ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 23806014]
KB	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 25442310]
KB	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity in human KB cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human KB cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
KB	IC₅₀	1.25 μM Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 22004007]
KB	IC₅₀	1.26 nM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as inhibition of cell growth after 3 days by MTT assay Cytotoxicity against human KB cells assessed as inhibition of cell growth after 3 days by MTT assay	[PMID: 24745968]
KB	IC₅₀	1.26 nM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human KB cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 25442315]
KB	IC₅₀	1.26 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as growth inhibition measured after 3 days by MTT assay Cytotoxicity against human KB cells assessed as growth inhibition measured after 3 days by MTT assay	[PMID: 27342752]
KB	IC₅₀	1.26 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as cell viability measured by MTT assay Cytotoxicity against human KB cells assessed as cell viability measured by MTT assay	[PMID: 33895275]
KB	IC₅₀	1.3 μM Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 26081288]
KB	IC₅₀	1.38 μM Compound: Ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 19265430]
KB	IC₅₀	1.4 μM Compound: EC	Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay	[PMID: 26516994]
KB	IC₅₀	1.66 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 26522953]
KB	IC₅₀	1.75 μM Compound: Ellipticine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 33556568]
KB	IC₅₀	1.78 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 3 days by resazurin microplate assay Cytotoxicity against human KB cells after 3 days by resazurin microplate assay	[PMID: 21641693]
KB	IC₅₀	1.79 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay	[PMID: 20362442]
KB	IC₅₀	1.79 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by SRB assay Cytotoxicity against human KB cells after 72 hrs by SRB assay	[PMID: 28512032]
KB	IC₅₀	1.79 μM Compound: ellipticine	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 21302964]
KB	IC₅₀	1.87 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay	[PMID: 28755636]
KB	IC₅₀	1.92 μM Compound: Ellipticine	Anticancer activity against human KB cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Anticancer activity against human KB cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 32527561]
KB	IC₅₀	1.95 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 3 days by MTT assay Cytotoxicity against human KB cells after 3 days by MTT assay	[PMID: 30337229]
KB	IC₅₀	1.98 μM Compound: ellipticine	Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay	[PMID: 25734623]
KB	IC₅₀	1.99 μM Compound: ellipticine	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 18363379]
KB	IC₅₀	2.03 μM Compound: Ellipticine	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 27228159]
KB	IC₅₀	2.07 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 48 hrs by SRB assay Cytotoxicity against human KB cells after 48 hrs by SRB assay	[PMID: 26099533]
KB	IC₅₀	2.15 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human KB cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
KB	IC₅₀	2.2 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay	[PMID: 33316411]
KB	IC₅₀	2.2 μM Compound: ellipticine	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 18380478]
KB	IC₅₀	2.25 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay	[PMID: 24857542]
KB	IC₅₀	2.4 μM Compound: elliptecine	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 16919455]
KB	IC₅₀	2.5 μM Compound: Ellipticine	Cytotoxicity against human KB cells by resazurin microplate assay Cytotoxicity against human KB cells by resazurin microplate assay	[PMID: 19739600]
KB	IC₅₀	2.5 μM Compound: ellipticine	Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay	[PMID: 20364867]
KB	IC₅₀	2.81 μM Compound: Ellipticine	Cytotoxicity against human KB cells after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human KB cells after 72 hrs by resazurin based fluorescence assay	[PMID: 28927795]
KB	IC₅₀	3.98 μM Compound: Ellipticine	Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
KB	IC₅₀	4.87 μM Compound: Ellipticine	Cytotoxicity against human KB cells by resazurin assay Cytotoxicity against human KB cells by resazurin assay	[PMID: 23806072]
KB	IC₅₀	5.2 μM Compound: ellipticine	Cytotoxicity against human KB cells by resazurin reduction assay Cytotoxicity against human KB cells by resazurin reduction assay	[PMID: 22482432]
KB	IC₅₀	5.3 μM Compound: ellipticine	Cytotoxicity against KB cells by colorimetric method Cytotoxicity against KB cells by colorimetric method	[PMID: 17480099]
KB	IC₅₀	5.41 μM Compound: Ellipticin	Cytotoxicity against human KB cells by colorimetric method Cytotoxicity against human KB cells by colorimetric method	[PMID: 17067151]
KB	IC₅₀	6.1 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin based fluorescence assay Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin based fluorescence assay	[PMID: 33852304]
KB	IC₅₀	8.12 x 10^-4 M Compound: ellipticine	Cytotoxicity against human KB cells by SRB assay Cytotoxicity against human KB cells by SRB assay	[PMID: 16933890]
KB	IC₅₀	8.2 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay	[PMID: 30860372]
KB	IC₅₀	8.28 μM Compound: Ellipticine	Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay	[PMID: 27311894]
L1210	ED₅₀	0.85 μM Compound: 19	The effective dose against L1210 cell growth The effective dose against L1210 cell growth	[PMID: 4009597]
L1210	IC₅₀	0.19 μM Compound: ellipticine	Cytotoxicity against mouse L1210 cell line Cytotoxicity against mouse L1210 cell line	[PMID: 17228871]
L1210	IC₅₀	0.5 μM Compound: Ellipticine	The compound was tested in vitro for growth inhibitory activity against murine leukemia L1210 cells The compound was tested in vitro for growth inhibitory activity against murine leukemia L1210 cells	10.1016/S0960-894X(97)10138-X
LNCaP	ED₅₀	0.8 μg/mL Compound: Ellipticine	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 12762797]
LNCaP	ED₅₀	0.8 μg/mL Compound: Ellipticine	Cytotoxicity against human LNCAP cells after 3 days by SRB assay Cytotoxicity against human LNCAP cells after 3 days by SRB assay	[PMID: 7528785]
LNCaP	IC₅₀	1.95 μM Compound: Ellipticine	Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay	[PMID: 28512032]
LNCaP	IC₅₀	1.99 μM Compound: Ellipticine	Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay	[PMID: 26099533]
LNCaP	IC₅₀	3.21 μM Compound: Ellipticine	Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
LNCaP	IC₅₀	3.25 μM Compound: ellipticine	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 14987058]
LOX IMVI	GI₅₀	0.56 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of melanoma LOX IMVI cells Cytotoxic effect on growth inhibition of melanoma LOX IMVI cells	[PMID: 8765520]
Lu1	ED₅₀	0.02 μg/mL Compound: Ellipticine	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 12762797]
Lu1	ED₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay	[PMID: 18271551]
Lu1	ED₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against human Lu1 cells after 3 days by SRB assay Cytotoxicity against human Lu1 cells after 3 days by SRB assay	[PMID: 7528785]
Lu1	ED₅₀	0.56 μg/mL Compound: Ellipticine	Cytotoxicity against human Lu1 cells by SRB assay Cytotoxicity against human Lu1 cells by SRB assay	[PMID: 17190450]
Lu1	ED₅₀	1.1 μM Compound: Ellipticine	Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay	[PMID: 23550966]
Lu1	ED₅₀	1.62 μM Compound: Ellipt	Cytotoxicity against human Lu1 cells by SRB assay Cytotoxicity against human Lu1 cells by SRB assay	[PMID: 22154665]
Lu1	IC₅₀	0.08 μM Compound: ellipticine	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 14987058]
Lu1	IC₅₀	1.2 μM Compound: EC	Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay	[PMID: 26516994]
Lu1	IC₅₀	1.39 μM Compound: Ellipticine	Cytotoxicity against human Lu1 cells after 3 days by MTT assay Cytotoxicity against human Lu1 cells after 3 days by MTT assay	[PMID: 27517802]
Lu1	IC₅₀	1.6 μM Compound: Ellipticine	Cytotoxicity in human Lu1 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human Lu1 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
Lu1	IC₅₀	1.7 μM Compound: Ellipticine	Antiproliferative activity against human Lu1 cells by MTT assay Antiproliferative activity against human Lu1 cells by MTT assay	[PMID: 31546197]
Lu1	IC₅₀	2.31 μM Compound: Ellipticine	Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay	[PMID: 26522953]
Lu1	IC₅₀	2.72 μM Compound: Ellipticine	Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MCF-10A	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human MCF10A cells assessed as cell viability after 5 days by MTT assay Cytotoxicity against human MCF10A cells assessed as cell viability after 5 days by MTT assay	[PMID: 26599533]
MCF-10A	IC₅₀	1.2 μM Compound: Ellipticine	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31400710]
MCF7	ED₅₀	0.4 μg/mL Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay	[PMID: 18271551]
MCF7	ED₅₀	1.66 μM Compound: Ellipticine	Growth inhibition of human MCF7 cells after 72 hrs by SRB assay Growth inhibition of human MCF7 cells after 72 hrs by SRB assay	[PMID: 29097170]
MCF7	ED₅₀	2.11 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells by SRB method Cytotoxicity against human MCF7 cells by SRB method	[PMID: 27793565]
MCF7	ED₅₀	2.3 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay	[PMID: 23550966]
MCF7	ED₅₀	2.71 μM Compound: Ellipt	Cytotoxicity against human MCF7 cells by SRB assay Cytotoxicity against human MCF7 cells by SRB assay	[PMID: 22154665]
MCF7	GI₅₀	0.71 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of breast cancer MCF-7 cells Cytotoxic effect on growth inhibition of breast cancer MCF-7 cells	[PMID: 8765520]
MCF7	GI₅₀	0.74 μM Compound: 1 (Ellipticine)	Cytotoxic effect of growth inhibition of breast cancer MCF-7/ADR-RES cells Cytotoxic effect of growth inhibition of breast cancer MCF-7/ADR-RES cells	[PMID: 8765520]
MCF7	GI₅₀	4.32 μM Compound: Ellipticine	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 24121236]
MCF7	IC₅₀	0.43 μM Compound: 1, Ellipticine	Cytotoxicity against human MCF7 cells after 96 hrs by crystal violet staining Cytotoxicity against human MCF7 cells after 96 hrs by crystal violet staining	[PMID: 19481463]
MCF7	IC₅₀	0.44 μg/mL Compound: Ellipticine	Antiproliferative activity against human MCF7 cells Antiproliferative activity against human MCF7 cells	[PMID: 26459207]
MCF7	IC₅₀	0.53 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 27517802]
MCF7	IC₅₀	0.8 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 31120251]
MCF7	IC₅₀	0.9 μM Compound: EC	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay	[PMID: 26516994]
MCF7	IC₅₀	1.05 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34838335]
MCF7	IC₅₀	1.25 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by MTT assay	[PMID: 26599533]
MCF7	IC₅₀	1.25 μM Compound: Ellipticine	Antiproliferative activity against ER-alpha positive human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against ER-alpha positive human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31400710]
MCF7	IC₅₀	1.34 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 28512032]
MCF7	IC₅₀	1.53 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay	[PMID: 28755636]
MCF7	IC₅₀	1.54 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay	[PMID: 26522953]
MCF7	IC₅₀	1.58 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 33556568]
MCF7	IC₅₀	1.6 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 20667744]
MCF7	IC₅₀	1.6 μM Compound: Ellipticine	Antitumor activity against human MCF7 cells after 72 hrs by MTT assay Antitumor activity against human MCF7 cells after 72 hrs by MTT assay	[PMID: 21458275]
MCF7	IC₅₀	1.6 μM Compound: Ellipticine	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	1.6 μM Compound: Ellipticine	Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	1.7 μM Compound: Ellipticine	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 31546197]
MCF7	IC₅₀	1.7 μM Compound: Ellipticine	Anticancer activity against human MCF7 cells Anticancer activity against human MCF7 cells	[PMID: 31945642]
MCF7	IC₅₀	1.7 μM Compound: Ellipticine	Anticancer activity against human MCF7 cells assessed as inhibition of cell growth Anticancer activity against human MCF7 cells assessed as inhibition of cell growth	[PMID: 31945642]
MCF7	IC₅₀	1.79 μM Compound: Ellipticine	Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 32527561]
MCF7	IC₅₀	1.8 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells Cytotoxicity against human MCF7 cells	[PMID: 26081288]
MCF7	IC₅₀	1.95 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 26099533]
MCF7	IC₅₀	1.99 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
MCF7	IC₅₀	16.72 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay	10.1039/C2MD20335A
MCF7	IC₅₀	2 μM Compound: Ellipticine	Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay	[PMID: 28006904]
MCF7	IC₅₀	2.1 nM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay	[PMID: 25442315]
MCF7	IC₅₀	2.15 nM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 3 days by MTT assay Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 3 days by MTT assay	[PMID: 24745968]
MCF7	IC₅₀	2.18 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay	[PMID: 33316411]
MCF7	IC₅₀	2.4 μM Compound: Ellipticine	Cytotoxicity in human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry Cytotoxicity in human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry	[PMID: 30108762]
MCF7	IC₅₀	2.48 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as cell viability measured by MTT assay Cytotoxicity against human MCF7 cells assessed as cell viability measured by MTT assay	[PMID: 33895275]
MCF7	IC₅₀	9.85 μM Compound: Ellipticine	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition by MTT assay	[PMID: 34838335]
MDA-MB-231	IC₅₀	0.1 μM Compound: Ellipticine	Antiproliferative activity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
MDA-MB-231	IC₅₀	1.05 μM Compound: Ellipticine	Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay	[PMID: 34838335]
MDA-MB-231	IC₅₀	1.82 μM Compound: Ellipticine	Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 5 days by MTT assay Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 5 days by MTT assay	[PMID: 26599533]
MDA-MB-231	IC₅₀	1.85 μM Compound: Ellipticine	Antiproliferative activity against triple negative human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay Antiproliferative activity against triple negative human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 31400710]
MDA-MB-231	IC₅₀	2.03 μM Compound: Ellipticine	Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured by SRB assay Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured by SRB assay	[PMID: 34044119]
MDA-MB-231	IC₅₀	2.3 μM Compound: Ellipticine	In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis) In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)	[PMID: 12036369]
MDA-MB-231	IC₅₀	3.21 μM Compound: Ellipticine	Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MKN-7	IC₅₀	3.82 μM Compound: Ellipticine	Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
MOLT-4	GI₅₀	0.38 μM Compound: 1 (Ellipticine)	Cytotoxic effect on leukemia MOLT-4 cells Cytotoxic effect on leukemia MOLT-4 cells	[PMID: 8765520]
MRC5	IC₅₀	1.3 μM Compound: Ellipticine	Antiproliferative activity against human MRC5 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human MRC5 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
MSTO-211H	GI₅₀	0.77 μM Compound: Ellipticine	Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay	[PMID: 30660826]
Macrophage	IC₅₀	> 1.4 x 10² μM Compound: 1, Ellipticine	Cytotoxicity against mouse macrophages after 18 hrs by MTT assay Cytotoxicity against mouse macrophages after 18 hrs by MTT assay	[PMID: 24813729]
Malme-3M	GI₅₀	2.52 μM Compound: 1	Tested in vitro for cytotoxicity in MALME-3M Tested in vitro for cytotoxicity in MALME-3M	[PMID: 8035426]
NCI-H1299	IC₅₀	0.6 μM Compound: Ellipticine	Antiproliferative activity against human H1299 cells after 3 days by SRB assay Antiproliferative activity against human H1299 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H187	IC₅₀	0.26 μg/mL Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 16441071]
NCI-H187	IC₅₀	0.26 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 19627125]
NCI-H187	IC₅₀	0.32 μg/mL Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 16038539]
NCI-H187	IC₅₀	0.32 μg/mL Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 19663417]
NCI-H187	IC₅₀	0.32 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 15730240]
NCI-H187	IC₅₀	0.32 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 16309322]
NCI-H187	IC₅₀	0.32 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 17845001]
NCI-H187	IC₅₀	0.3 μg/mL Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay	[PMID: 19368377]
NCI-H187	IC₅₀	0.3 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by colorimetric assay Cytotoxicity against human NCI-H187 cells by colorimetric assay	[PMID: 16378377]
NCI-H187	IC₅₀	0.44 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay	[PMID: 19555123]
NCI-H187	IC₅₀	0.44 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 19778068]
NCI-H187	IC₅₀	0.4 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 15217275]
NCI-H187	IC₅₀	0.52 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 18179177]
NCI-H187	IC₅₀	0.68 μg/mL Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by resazurin microplate assay Cytotoxicity against human NCI-H187 cells by resazurin microplate assay	[PMID: 20329738]
NCI-H187	IC₅₀	0.8 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 16038559]
NCI-H187	IC₅₀	0.95 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells after 72 hrs by resazurin based fluorescence assay Cytotoxicity against human NCI-H187 cells after 72 hrs by resazurin based fluorescence assay	[PMID: 28927795]
NCI-H187	IC₅₀	1.16 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 23806014]
NCI-H187	IC₅₀	1.5 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay	[PMID: 20364867]
NCI-H187	IC₅₀	1.59 μM Compound: Ellipticin	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 17067151]
NCI-H187	IC₅₀	1.71 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 18363379]
NCI-H187	IC₅₀	1.82 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 22004007]
NCI-H187	IC₅₀	1.9 μM Compound: elliptecine	Cytotoxicity against human NCI-H187 cells Cytotoxicity against human NCI-H187 cells	[PMID: 16919455]
NCI-H187	IC₅₀	13.7 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay	[PMID: 34748348]
NCI-H187	IC₅₀	2 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by colorimetric method Cytotoxicity against human NCI-H187 cells by colorimetric method	[PMID: 18380478]
NCI-H187	IC₅₀	2.23 x 10^-3 M Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 16933890]
NCI-H187	IC₅₀	2.76 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 by resazurin microplate assay Cytotoxicity against human NCI-H187 by resazurin microplate assay	[PMID: 21302964]
NCI-H187	IC₅₀	2.77 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay	[PMID: 20362442]
NCI-H187	IC₅₀	2.77 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells after 5 days by resazurin microplate assay Cytotoxicity against human NCI-H187 cells after 5 days by resazurin microplate assay	[PMID: 21641693]
NCI-H187	IC₅₀	3.1 μM Compound: ellipticine	Cytotoxicity against human NCI-H187 cells by resazurin reduction assay Cytotoxicity against human NCI-H187 cells by resazurin reduction assay	[PMID: 22482432]
NCI-H187	IC₅₀	3.6 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by resazurin microplate assay Cytotoxicity against human NCI-H187 cells by resazurin microplate assay	[PMID: 19739600]
NCI-H187	IC₅₀	4.4 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by SRB assay Cytotoxicity against human NCI-H187 cells by SRB assay	[PMID: 19265430]
NCI-H187	IC₅₀	9.1 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin based fluorescence assay Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin based fluorescence assay	[PMID: 33852304]
NCI-H187	IC₅₀	9.3 μM Compound: Ellipticine	Cytotoxicity against human NCI-H187 cells by resazurin microplate assay Cytotoxicity against human NCI-H187 cells by resazurin microplate assay	[PMID: 32193929]
NCI-H1993	IC₅₀	0.2 μM Compound: Ellipticine	Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H292	IC₅₀	1 μM Compound: Ellipticine	Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H322M	GI₅₀	0.31 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of nonsmall cell lung cancer NCI-H322M cells Cytotoxic effect on growth inhibition of nonsmall cell lung cancer NCI-H322M cells	[PMID: 8765520]
NCI-H358	IC₅₀	0.2 μM Compound: 1 (ellipticin)	Compound was evaluated for inhibitory activity against H 358 human lung cancer cell line Compound was evaluated for inhibitory activity against H 358 human lung cancer cell line	[PMID: 1479585]
NCI-H358	IC₅₀	0.8 μM Compound: Ellipticine	Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay	[PMID: 21916433]
NCI-H417	IC₅₀	0.87 μM Compound: 1 (ellipticin)	Compound was evaluated for inhibitory activity against N 417 human lung cancer cell line Compound was evaluated for inhibitory activity against N 417 human lung cancer cell line	[PMID: 1479585]
NCI-H460	GI₅₀	5.77 μM Compound: Ellipticine	Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay	[PMID: 24121236]
NCI-H460	IC₅₀	0.51 μM Compound: 1 (ellipticin)	Compound was evaluated for inhibitory activity against H 460 human lung cancer cell line Compound was evaluated for inhibitory activity against H 460 human lung cancer cell line	[PMID: 1479585]
NCI-H69	IC₅₀	1.8 μM Compound: 1 (ellipticin)	Compound was evaluated for inhibitory activity against H69 human lung cancer cell line Compound was evaluated for inhibitory activity against H69 human lung cancer cell line	[PMID: 1479585]
NHDF	IC₅₀	> 10 μM Compound: Ellipticine	Antitumor activity against human NHDF cells after 72 hrs by MTT assay Antitumor activity against human NHDF cells after 72 hrs by MTT assay	[PMID: 21458275]
NIH3T3	IC₅₀	0.003 μM Compound: 1, Ellipticine	Growth inhibition of mouse NIH3T3 cells by MTT assay Growth inhibition of mouse NIH3T3 cells by MTT assay	[PMID: 17376678]
NIH3T3	IC₅₀	0.3 μM Compound: 1	Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28063783]
NIH3T3	IC₅₀	0.32 μM Compound: Ellipticine	Cytotoxicity against mouse NIH/3T3 cells after 3 days by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 3 days by MTT assay	[PMID: 27517802]
NIH3T3	IC₅₀	1.3 μM Compound: EC	Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay	[PMID: 26516994]
OVCAR	ED₅₀	0.58 μg/mL Compound: Ellipticine	Cytotoxicity against human OVCAR cells after 72 hrs by SRB method Cytotoxicity against human OVCAR cells after 72 hrs by SRB method	[PMID: 10479311]
P338	IC₅₀	0.44 μg/mL Compound: Ellipticine	Antiproliferative activity against mouse P338 cells Antiproliferative activity against mouse P338 cells	[PMID: 26459207]
P338	IC₅₀	1.27 μM Compound: Ellipticine	Cytotoxicity against mouse P338 cells after 3 days by MTT assay Cytotoxicity against mouse P338 cells after 3 days by MTT assay	[PMID: 27517802]
P388	ED₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against mouse P388 cells after 72 hrs by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 72 hrs by sulforhodamine B assay	[PMID: 18271551]
P388	ED₅₀	0.52 μg/mL Compound: Ellipticine	Cytotoxicity against mouse P388 cells by SRB assay Cytotoxicity against mouse P388 cells by SRB assay	[PMID: 17190450]
P388	ED₅₀	1.9 μM Compound: Ellipticine	Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay	[PMID: 23550966]
P388	ED₅₀	2.12 μM Compound: Ellipticine	Growth inhibition of mouse P388 cells after 72 hrs by SRB assay Growth inhibition of mouse P388 cells after 72 hrs by SRB assay	[PMID: 29097170]
P388	ED₅₀	2.15 μM Compound: Ellipticine	Cytotoxicity against mouse P388 cells by SRB method Cytotoxicity against mouse P388 cells by SRB method	[PMID: 27793565]
P388	ED₅₀	2.44 μM Compound: Ellipt	Cytotoxicity against mouse P388 cells by SRB assay Cytotoxicity against mouse P388 cells by SRB assay	[PMID: 22154665]
P388	ED₅₀	< 1 μg/mL Compound: Ellipticine	Toxicity against mouse P388 cells Toxicity against mouse P388 cells	[PMID: 17067158]
P388	IC₅₀	1.34 μM Compound: Ellipticine	Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by SRB assay Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by SRB assay	[PMID: 28755636]
P388	IC₅₀	1.7 μM Compound: Ellipticine	Antiproliferative activity against mouse P388 cells by MTT assay Antiproliferative activity against mouse P388 cells by MTT assay	[PMID: 31546197]
P388	IC₅₀	1.7 μM Compound: Ellipticine	Anticancer activity against mouse P388 cells Anticancer activity against mouse P388 cells	[PMID: 31945642]
P388	IC₅₀	1.79 μM Compound: Ellipticine	Anticancer activity against mouse P388 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay Anticancer activity against mouse P388 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay	[PMID: 32527561]
P388	IC₅₀	1.84 μM Compound: Ellipticine	Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by Sulforhodamine B assay Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by Sulforhodamine B assay	[PMID: 29606574]
R1	IC₅₀	90 μM Compound: 3	Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay	[PMID: 18412397]
RT-4	IC₅₀	1.21 μM Compound: 1, Ellipticine	Cytotoxicity against human RT4 cells after 96 hrs by crystal violet staining Cytotoxicity against human RT4 cells after 96 hrs by crystal violet staining	[PMID: 19481463]
SF-268	GI₅₀	0.816 μM Compound: 1	Tested in vitro for cytotoxicity in SF-268 cell lines Tested in vitro for cytotoxicity in SF-268 cell lines	[PMID: 8035426]
SH-SY5Y	IC₅₀	2.13 μM Compound: Ellipticine	Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured by SRB assay Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured by SRB assay	[PMID: 34044119]
SK-HEP1	IC₅₀	0.4 μM Compound: Ellipticine	Antiproliferative activity against human SKHEP1 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human SKHEP1 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
SK-LU-1	IC₅₀	1.38 μM Compound: Ellipticine	Cytotoxicity against human SK-LU-1 cells after 3 days by MTT assay Cytotoxicity against human SK-LU-1 cells after 3 days by MTT assay	[PMID: 30337229]
SK-LU-1	IC₅₀	1.54 μM Compound: Ellipticine	Cytotoxicity against human SK-LU-1 cells Cytotoxicity against human SK-LU-1 cells	[PMID: 33556568]
SK-MEL-2	IC₅₀	1.14 μM Compound: Ellipticine	Cytotoxic activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
SK-MEL-2	IC₅₀	1.91 μM Compound: Ellipticine	Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay	[PMID: 28512032]
SK-MEL-2	IC₅₀	2.15 μM Compound: Ellipticine	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 26099533]
SK-MES-1	IC₅₀	0.2 μM Compound: Ellipticine	Antiproliferative activity against human SK-MES cells after 3 days by SRB assay Antiproliferative activity against human SK-MES cells after 3 days by SRB assay	[PMID: 21916433]
SN12C	GI₅₀	0.73 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of renal cancer SN12C cells Cytotoxic effect on growth inhibition of renal cancer SN12C cells	[PMID: 8765520]
SNU-638	IC₅₀	1.64 μM Compound: Ellipticine	Cytotoxicity against human SNU638 cells after 6 days by SRB assay Cytotoxicity against human SNU638 cells after 6 days by SRB assay	[PMID: 21330015]
SNU-638	IC₅₀	2 μM Compound: Ellipticine	In vitro cytotoxicity against human SNU-638 (stomach cancer) cell line. In vitro cytotoxicity against human SNU-638 (stomach cancer) cell line.	[PMID: 15177438]
SNU-638	IC₅₀	2.2 μM Compound: Ellipticine	Cytotoxicity against human SNU638 cells Cytotoxicity against human SNU638 cells	[PMID: 21095131]
SNU-638	IC₅₀	2.2 μM Compound: Ellipticine	Cytotoxicity against human SNU638 cells by MTT assay Cytotoxicity against human SNU638 cells by MTT assay	[PMID: 21353568]
SNU-638	IC₅₀	2.2 μM Compound: ellipticine	Cytotoxicity against human SNU638 cells by SRB assay Cytotoxicity against human SNU638 cells by SRB assay	[PMID: 17498951]
SNU-638	IC₅₀	2.7 μM Compound: Ellipticine	Antiproliferative activity against human SNU638 cells after 24 to 72 hrs by SRB assay Antiproliferative activity against human SNU638 cells after 24 to 72 hrs by SRB assay	[PMID: 27064730]
SNU-638	IC₅₀	5.97 μM Compound: ellipticine	Cytotoxicity against human SNU638 cells after 3 days by SRB assay Cytotoxicity against human SNU638 cells after 3 days by SRB assay	[PMID: 17035025]
SW480	IC₅₀	0.38 μg/mL Compound: Ellipticine	Antiproliferative activity against human SW480 cells Antiproliferative activity against human SW480 cells	[PMID: 26459207]
SW480	IC₅₀	0.75 μM Compound: Ellipticine	Cytotoxicity against human SW480 cells after 3 days by MTT assay Cytotoxicity against human SW480 cells after 3 days by MTT assay	[PMID: 27517802]
SW480	IC₅₀	3.17 μM Compound: Ellipticine	Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method	[PMID: 26077495]
Sarcoma-180	IC₅₀	2 μM Compound: 1	Cytotoxicity against mouse Sarcoma 180 cells assessed as reduction in cell viability after 72 hrs by MTT assay Cytotoxicity against mouse Sarcoma 180 cells assessed as reduction in cell viability after 72 hrs by MTT assay	[PMID: 28063783]
U-251	GI₅₀	0.93 μM Compound: 1 (Ellipticine)	Cytotoxic effect on growth inhibition of CNS cancer U251 cells Cytotoxic effect on growth inhibition of CNS cancer U251 cells	[PMID: 8765520]
Vero	IC₅₀	0.2 μg/mL Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 12828479]
Vero	IC₅₀	0.2 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 15043440]
Vero	IC₅₀	0.4 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay	[PMID: 26928423]
Vero	IC₅₀	0.48 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 19778068]
Vero	IC₅₀	0.4 μg/mL Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay	[PMID: 19368377]
Vero	IC₅₀	0.4 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 11277765]
Vero	IC₅₀	0.6 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 16309322]
Vero	IC₅₀	0.7 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay	[PMID: 19943622]
Vero	IC₅₀	0.8 μM Compound: ellipticine	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 16038559]
Vero	IC₅₀	0.87 μg/mL Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay	[PMID: 32639735]
Vero	IC₅₀	1 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells Cytotoxicity against African green monkey Vero cells	[PMID: 27228159]
Vero	IC₅₀	1.16 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 19456117]
Vero	IC₅₀	1.18 μg/mL Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein assay	[PMID: 20329738]
Vero	IC₅₀	1.19 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 23806014]
Vero	IC₅₀	1.69 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by SRB assay Cytotoxicity against african green monkey Vero cells by SRB assay	[PMID: 19265430]
Vero	IC₅₀	1.75 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by SRB assay Cytotoxicity against African green monkey Vero cells by SRB assay	[PMID: 20038128]
Vero	IC₅₀	1.94 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells after 4 days by GFP detection method Cytotoxicity against african green monkey Vero cells after 4 days by GFP detection method	[PMID: 24836071]
Vero	IC₅₀	1.94 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 4 days by green fluorescent protein detection method Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 4 days by green fluorescent protein detection method	[PMID: 25078311]
Vero	IC₅₀	1.94 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells after 4 days by green fluorescent protein detection method Cytotoxicity against african green monkey Vero cells after 4 days by green fluorescent protein detection method	[PMID: 25934226]
Vero	IC₅₀	1.94 μM Compound: Ellipticine	Cytotoxicity against GFP-expressing African green monkey Vero cells after 4 days by fluorescence assay Cytotoxicity against GFP-expressing African green monkey Vero cells after 4 days by fluorescence assay	[PMID: 29137864]
Vero	IC₅₀	1.94 μM Compound: ellipticine	Cytotoxicity against African green monkey Vero cells by colorimetric method Cytotoxicity against African green monkey Vero cells by colorimetric method	[PMID: 18363379]
Vero	IC₅₀	12 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21473608]
Vero	IC₅₀	15.51 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay	[PMID: 25337628]
Vero	IC₅₀	1 μg/mL Compound: elipticine	Cytotoxicity against african green monkey kidney fibroblast (vero cell) Cytotoxicity against african green monkey kidney fibroblast (vero cell)	[PMID: 12773043]
Vero	IC₅₀	2.03 μM Compound: ellipticine	Cytotoxicity against African green monkey Vero cells after 72 hrs Cytotoxicity against African green monkey Vero cells after 72 hrs	[PMID: 17892262]
Vero	IC₅₀	2.1 μM Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by colorimetric method Cytotoxicity against african green monkey Vero cells by colorimetric method	[PMID: 18380478]
Vero	IC₅₀	2.29 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein based assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein based assay	[PMID: 20362442]
Vero	IC₅₀	2.4 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay	[PMID: 34624822]
Vero	IC₅₀	2.44 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 16499340]
Vero	IC₅₀	2.9 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition by GFP fluorescence based assay Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition by GFP fluorescence based assay	[PMID: 37816683]
Vero	IC₅₀	3.1 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by GFP based microplate assay Cytotoxicity against African green monkey Vero cells by GFP based microplate assay	[PMID: 30983350]
Vero	IC₅₀	3.3 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 26716912]
Vero	IC₅₀	3.3 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by GFP based microplate assay Cytotoxicity against African green monkey Vero cells by GFP based microplate assay	[PMID: 28504879]
Vero	IC₅₀	3.8 μM Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 20364867]
Vero	IC₅₀	3.8 μM Compound: ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay	[PMID: 25734623]
Vero	IC₅₀	3.82 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells expressing green fluorescent protein after 4 days by fluorescence analysis Cytotoxicity against african green monkey Vero cells expressing green fluorescent protein after 4 days by fluorescence analysis	[PMID: 21641693]
Vero	IC₅₀	3.82 μM Compound: ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21302964]
Vero	IC₅₀	4.05 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells after 4 days by GFP detection method Cytotoxicity against African green monkey Vero cells after 4 days by GFP detection method	[PMID: 26397393]
Vero	IC₅₀	4.06 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by GFP-based assay Cytotoxicity against African green monkey Vero cells by GFP-based assay	[PMID: 30078607]
Vero	IC₅₀	4.06 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31620225]
Vero	IC₅₀	4.1 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay	[PMID: 30860372]
Vero	IC₅₀	4.26 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay	[PMID: 27311894]
Vero	IC₅₀	4.47 μM Compound: ellipticine	Cytotoxicity against african green monkey Vero cells Cytotoxicity against african green monkey Vero cells	[PMID: 20815366]
Vero	IC₅₀	4.5 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay	[PMID: 34748348]
Vero	IC₅₀	4 μg/mL Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by colorimetric assay Cytotoxicity against African green monkey Vero cells by colorimetric assay	[PMID: 33861594]
Vero	IC₅₀	5.5 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells after 8 days by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells after 8 days by green fluorescent protein microplate assay	[PMID: 19739600]
Vero	IC₅₀	6.48 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method	[PMID: 24857542]
Vero	IC₅₀	7.47 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay	[PMID: 32193929]
Vero	IC₅₀	7.9 μM Compound: Ellipticine	Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 33852304]
Vero	IC₅₀	9.8 μM Compound: Ellipticine	Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay	[PMID: 21995505]
ZR-75-1	ED₅₀	0.9 μg/mL Compound: Ellipticine	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	[PMID: 7528785]

In Vitro

Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases^[1]. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ellipticine (NSC 71795) treatment results in Ellipticine (NSC 71795)-derived DNA adduct generation in several healthy organs (liver, kidney, lung, spleen, breast, heart and brain) and in DNA of mammary adenocarcinoma. The levels of Ellipticine (NSC 71795)-derived DNA adducts generated in these adenocarcinomas are almost 2-fold higher than in normal healthy mammary tissue. The induced expression of cytochrome b₅ protein in liver of rats treated with Ellipticine (NSC 71795) suggests that cytochrome b₅ may modulate the CYP-mediated bioactivation and detoxification of Ellipticine (NSC 71795)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

246.31

Formula

C₁₇H₁₄N₂

CAS No.

519-23-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 5.8 mg/mL (23.55 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0599 mL	20.2996 mL	40.5992 mL
5 mM	0.8120 mL	4.0599 mL	8.1198 mL
10 mM	0.4060 mL	2.0300 mL	4.0599 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.16 mg/mL (8.77 mM); Clear solution

This protocol yields a clear solution of ≥ 2.16 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (281 KB) SDS (480 KB)

COA (255 KB) HNMR (132 KB) RP-HPLC (168 KB) LCMS (103 KB)

Handling Instructions (2659 KB)

References

[1]. Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. [Content Brief]

[2]. Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. [Content Brief]

[3]. Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. [Content Brief]

Cell Assay
^[2]

The cytotoxicity of ellipticine is determined by MTT test. Ellipticine (NSC 71795) is dissolved in DMSO (1 mM) and diluted in culture medium to final concentrations of 0, 0.1, 1, 5 or 10 μM. Cells in exponential growth are seeded at 1×10⁴ per well in a 96-well microplate. After incubation the MTT solution is added, the microplates are incubated for 4 hours and cells lysed in 50% N,N-dimethylformamide containing 20% of sodium dodecyl sulfate (SDS), pH 4.5. The absorbance at 570 nm is measured. The mean absorbance of medium controls is subtracted as a background. The viability of control cells is taken as 100% and the values of treated cells are calculated as a percentage of control. The IC₅₀ values are calculated using linear regression of the dose-log response curves^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. [Content Brief]

[2]. Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. [Content Brief]

[3]. Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0599 mL	20.2996 mL	40.5992 mL	101.4981 mL
	5 mM	0.8120 mL	4.0599 mL	8.1198 mL	20.2996 mL
	10 mM	0.4060 mL	2.0300 mL	4.0599 mL	10.1498 mL
	15 mM	0.2707 mL	1.3533 mL	2.7066 mL	6.7665 mL
	20 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0749 mL

Ellipticine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ellipticine519-23-3NSC 71795NSC71795NSC-71795TopoisomeraseInhibitorinhibitorinhibit

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Ellipticine (Synonyms: NSC 71795)

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