Ellipticine
Based on 4 publication(s) in Google Scholar
Ellipticine (NSC 71795) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.
For research use only. We do not sell to patients.
- Purity: 99.59%
- CAS No.: 519-23-3
- Formula: C17H14N2
- Molecular Weight:246.31
-
Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications Citing Use of MedChemExpress (MCE) Ellipticine
MoreAll Topoisomerase Isoforms
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Biological Activity
|
Topoisomerase II |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 5637 | IC50 |
0.89 μM
Compound: 1, Ellipticine
|
Cytotoxicity against human 5637 cells after 96 hrs by crystal violet staining
Cytotoxicity against human 5637 cells after 96 hrs by crystal violet staining
|
[PMID: 19481463] |
| A-427 | IC50 |
0.89 μM
Compound: 1, Ellipticine
|
Cytotoxicity against human A427 cells after 96 hrs by crystal violet staining
Cytotoxicity against human A427 cells after 96 hrs by crystal violet staining
|
[PMID: 19481463] |
| A-431 | IC50 |
0.47 μM
Compound: Ellipticine
|
Growth inhibition in human A431 cells after 72 hrs by trypan blue assay
Growth inhibition in human A431 cells after 72 hrs by trypan blue assay
|
[PMID: 21216603] |
| A-431 | GI50 |
3.2 μM
Compound: Ellipticine
|
Growth inhibition of human A431 cells after 72 hrs by trypan blue assay
Growth inhibition of human A431 cells after 72 hrs by trypan blue assay
|
[PMID: 24631729] |
| A-431 | GI50 |
0.65 μM
Compound: Ellipticine
|
Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay
Growth inhibition in human A431 cells after 72 hrs by trypan blue dye-based assay
|
[PMID: 30660826] |
| A498 | IC50 |
1.74 μM
Compound: Ellipticine
|
Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A498 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
|
[PMID: 34838335] |
| A549 | IC50 |
10 μM
Compound: Ellipticine
|
In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
In vitro cytotoxic activity against human lung A549 cell line ( standard deviation in parenthesis)
|
[PMID: 12036369] |
| A549 | IC50 |
1.22 μM
Compound: Ellipticine
|
In vitro cytotoxicity against human A549 (lung cancer) cell line.
In vitro cytotoxicity against human A549 (lung cancer) cell line.
|
[PMID: 15177438] |
| A549 | IC50 |
2.07 μM
Compound: ellipticine
|
Cytotoxicity against human A549 cells after 3 days by SRB assay
Cytotoxicity against human A549 cells after 3 days by SRB assay
|
[PMID: 17035025] |
| A549 | IC50 |
1.9 μM
Compound: ellipticine
|
Cytotoxicity against human A549 cells by SRB assay
Cytotoxicity against human A549 cells by SRB assay
|
[PMID: 17498951] |
| A549 | IC50 |
3.4 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
Cytotoxicity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 20667744] |
| A549 | IC50 |
1.9 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
|
[PMID: 21095131] |
| A549 | IC50 |
0.47 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells after 6 days by SRB assay
Cytotoxicity against human A549 cells after 6 days by SRB assay
|
[PMID: 21330015] |
| A549 | IC50 |
1.9 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells by MTT assay
Cytotoxicity against human A549 cells by MTT assay
|
[PMID: 21353568] |
| A549 | IC50 |
3.4 μM
Compound: Ellipticine
|
Antitumor activity against human A549 cells after 72 hrs by MTT assay
Antitumor activity against human A549 cells after 72 hrs by MTT assay
|
[PMID: 21458275] |
| A549 | IC50 |
1.1 μM
Compound: Ellipticine
|
Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
|
[PMID: 21916433] |
| A549 | IC50 |
0.4 μM
Compound: Ellipticine
|
Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human A549 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| A549 | ED50 |
1.26 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells by SRB method
Cytotoxicity against human A549 cells by SRB method
|
[PMID: 27793565] |
| A549 | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 28755636] |
| A549 | ED50 |
2.37 μM
Compound: Ellipticine
|
Growth inhibition of human A549 cells after 72 hrs by SRB assay
Growth inhibition of human A549 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| A549 | IC50 |
1.96 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| A549 | IC50 |
2.25 μM
Compound: Ellipticine
|
Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Anticancer activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 32527561] |
| A549 | IC50 |
2.13 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 33316411] |
| A549 | IC50 |
1.16 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells assessed as growth inhibition measured by SRB assay
Cytotoxicity against human A549 cells assessed as growth inhibition measured by SRB assay
|
[PMID: 34044119] |
| A549 | IC50 |
0.85 μM
Compound: Ellipticine
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
Antiproliferative activity against human A549 cells assessed as cell growth inhibition measured after 72 hrs by SRB assay
|
[PMID: 34838335] |
| A549 | IC50 |
3.45 μM
Compound: Ellipticine
|
Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell growth inhibition incubated for 48 hrs by MTT assay
|
[PMID: 35219149] |
| A549 | GI50 |
0.41 μM
Compound: 1
|
Tested in vitro for cytotoxicity in A549/ATCC cell lines
Tested in vitro for cytotoxicity in A549/ATCC cell lines
|
[PMID: 8035426] |
| BC | IC50 |
0.1 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 11277765] |
| BC | IC50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC cells
Cytotoxicity against human BC cells
|
[PMID: 12828479] |
| BC | IC50 |
0.2 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 15043440] |
| BC | IC50 |
0.4 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC cells
Cytotoxicity against human BC cells
|
[PMID: 15217275] |
| BC | IC50 |
0.36 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
|
[PMID: 16038539] |
| BC | IC50 |
0.8 μM
Compound: ellipticine
|
Cytotoxicity against human BC cells
Cytotoxicity against human BC cells
|
[PMID: 16038559] |
| BC | IC50 |
0.27 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 16309322] |
| BC | IC50 |
0.3 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC cells by colorimetric assay
Cytotoxicity against human BC cells by colorimetric assay
|
[PMID: 16378377] |
| BC | IC50 |
0.32 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC clls
Cytotoxicity against human BC clls
|
[PMID: 16441071] |
| BC | IC50 |
2.7 μM
Compound: elliptecine
|
Cytotoxicity against human BC cells
Cytotoxicity against human BC cells
|
[PMID: 16919455] |
| BC | IC50 |
6.82 x 10-4 M
Compound: ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 16933890] |
| BC | IC50 |
6.82 x 10-4 mM
Compound: ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 16933890] |
| BC | IC50 |
0.14 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
|
[PMID: 16989536] |
| BC | IC50 |
6.1 μM
Compound: ellipticine
|
Cytotoxicity against BC cells by colorimetric method
Cytotoxicity against BC cells by colorimetric method
|
[PMID: 17480099] |
| BC | IC50 |
0.49 μM
Compound: ellipticine
|
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
|
[PMID: 18363379] |
| BC | IC50 |
1.2 μM
Compound: ellipticine
|
Cytotoxicity against human BC cells by colorimetric method
Cytotoxicity against human BC cells by colorimetric method
|
[PMID: 18380478] |
| BC | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human BC cells by SRB assay
Cytotoxicity against human BC cells by SRB assay
|
[PMID: 19265430] |
| BC1 cell line | IC50 |
0.6 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC1 cells by SRB assay
Cytotoxicity against human BC1 cells by SRB assay
|
[PMID: 11520217] |
| BC1 cell line | IC50 |
0.3 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 12350163] |
| BC1 cell line | IC50 |
0.3 μg/mL
Compound: Ellipticine
|
Cytotoxicity against BC-1 cell line
Cytotoxicity against BC-1 cell line
|
[PMID: 12657257] |
| BC1 cell line | IC50 |
0.26 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 15730240] |
| BC1 cell line | IC50 |
0.22 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC1 cells by MTT assay
Cytotoxicity against human BC1 cells by MTT assay
|
[PMID: 16792425] |
| BC1 cell line | IC50 |
5.93 μM
Compound: Ellipticin
|
Cytotoxicity against human BC1 cells by colorimetric method
Cytotoxicity against human BC1 cells by colorimetric method
|
[PMID: 17067151] |
| BC1 cell line | IC50 |
0.13 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 17567069] |
| BC1 cell line | IC50 |
0.26 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 17845001] |
| BC1 cell line | IC50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC1 cells by sulforhodamine B assay
Cytotoxicity against human BC1 cells by sulforhodamine B assay
|
[PMID: 19368377] |
| BC1 cell line | IC50 |
0.32 μg/mL
Compound: ellipticine
|
Cytotoxicity against human BC1 cells by SRB assay
Cytotoxicity against human BC1 cells by SRB assay
|
[PMID: 19627125] |
| BC1 cell line | IC50 |
0.26 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human BC1 cells by SRB assay
Cytotoxicity against human BC1 cells by SRB assay
|
[PMID: 19663417] |
| Breast carcinoma cell | IC50 |
0.1 μg/mL
Compound: Ellipticine
|
Cytotoxic concentration of compound against human breast cancer cells
Cytotoxic concentration of compound against human breast cancer cells
|
[PMID: 12729658] |
| CAKI-1 | GI50 |
1.01 μM
Compound: 1
|
Tested in vitro for cytotoxicity in CAKI-1 cell lines
Tested in vitro for cytotoxicity in CAKI-1 cell lines
|
[PMID: 8035426] |
| Cancer cell lines | IC50 |
0.13 μg/mL
Compound: ellipticine
|
Cytotoxicity against human breast cancer cells
Cytotoxicity against human breast cancer cells
|
[PMID: 18179177] |
| Cancer cell lines | ED50 |
2.19 μM
Compound: Ellipticine
|
Cytotoxicity against human colon cancer cells by SRB method
Cytotoxicity against human colon cancer cells by SRB method
|
[PMID: 27793565] |
| CCRF-CEM | GI50 |
0.415 μM
Compound: 1
|
Tested in vitro for cytotoxicity in CCRF-CEM cell lines
Tested in vitro for cytotoxicity in CCRF-CEM cell lines
|
[PMID: 8035426] |
| CHO | IC50 |
0.0193 μM
Compound: 1
|
Bioactivation in CYP1A1 (unknown origin) transfected CHO cells assessed as CYP1A1-mediated drug activation by measuring reduction in cell viability
Bioactivation in CYP1A1 (unknown origin) transfected CHO cells assessed as CYP1A1-mediated drug activation by measuring reduction in cell viability
|
[PMID: 31675512] |
| CHO | IC50 |
0.02 μM
Compound: 1
|
Cytotoxicity against CHO cells assessed as reduction in cell viability
Cytotoxicity against CHO cells assessed as reduction in cell viability
|
[PMID: 31675512] |
| Col2 | ED50 |
0.3 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 12762797] |
| Col2 | IC50 |
1.22 μM
Compound: ellipticine
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 14987058] |
| Col2 | IC50 |
1.22 μM
Compound: Ellipticine
|
In vitro cytotoxicity against human Col2 (colon cancer) cell line.
In vitro cytotoxicity against human Col2 (colon cancer) cell line.
|
[PMID: 15177438] |
| Col2 | IC50 |
1.82 μM
Compound: ellipticine
|
Cytotoxicity against human Col2 cells after 3 days by SRB assay
Cytotoxicity against human Col2 cells after 3 days by SRB assay
|
[PMID: 17035025] |
| Col2 | ED50 |
0.53 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells by SRB assay
Cytotoxicity against human Col2 cells by SRB assay
|
[PMID: 17190450] |
| Col2 | IC50 |
2.3 μM
Compound: ellipticine
|
Cytotoxicity against human Col2 cells by SRB assay
Cytotoxicity against human Col2 cells by SRB assay
|
[PMID: 17498951] |
| Col2 | ED50 |
0.5 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 18271551] |
| Col2 | IC50 |
2.3 μM
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 21095131] |
| Col2 | IC50 |
2.3 μM
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells by MTT assay
Cytotoxicity against human Col2 cells by MTT assay
|
[PMID: 21353568] |
| Col2 | ED50 |
2.72 μM
Compound: Ellipt
|
Cytotoxicity against human Col2 cells by SRB assay
Cytotoxicity against human Col2 cells by SRB assay
|
[PMID: 22154665] |
| Col2 | ED50 |
2.2 μM
Compound: Ellipticine
|
Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Col2 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| COLO 205 | GI50 |
0.588 μM
Compound: 1
|
Tested in vitro for cytotoxicity in COLO 205 cell lines
Tested in vitro for cytotoxicity in COLO 205 cell lines
|
[PMID: 8035426] |
| DMS-114 | GI50 |
0.552 μM
Compound: 1
|
Tested in vitro for cytotoxicity in DMS114 cell lines
Tested in vitro for cytotoxicity in DMS114 cell lines
|
[PMID: 8035426] |
| FaDu | IC50 |
1.85 μM
Compound: Ellipticine
|
Cytotoxicity against human FaDu cells assessed as growth inhibition measured by SRB assay
Cytotoxicity against human FaDu cells assessed as growth inhibition measured by SRB assay
|
[PMID: 34044119] |
| HCT-116 | IC50 |
0.3 μM
Compound: 1, Ellipticine
|
Growth inhibition of human HCT116 cells by MTT assay
Growth inhibition of human HCT116 cells by MTT assay
|
[PMID: 17376678] |
| HCT-116 | IC50 |
0.41 μM
Compound: Ellipticine
|
Cytotoxicity against human HCT116 cells after 6 days by SRB assay
Cytotoxicity against human HCT116 cells after 6 days by SRB assay
|
[PMID: 21330015] |
| HCT-116 | IC50 |
1 μM
Compound: Ellipticine
|
Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human HCT116 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| HCT-116 | GI50 |
0.29 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of colon cancer HCT116 cells
Cytotoxic effect on growth inhibition of colon cancer HCT116 cells
|
[PMID: 8765520] |
| HCT-15 | ED50 |
0.24 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB method
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB method
|
[PMID: 10479311] |
| HCT-15 | GI50 |
1.91 μM
Compound: Ellipticine
|
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
Growth inhibition of human HCT15 cells after 48 hrs by SRB assay
|
[PMID: 24121236] |
| HCT-15 | ED50 |
0.17 μg/mL
Compound: ellipticine
|
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
Cytotoxicity against human HCT-15 cells after 72 hrs by SRB assay
|
[PMID: 9917280] |
| HEK293 | ED50 |
1.9 μM
Compound: Ellipticine
|
Cytotoxicity against human HEK293 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HEK293 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| HEK293 | ED50 |
2.03 μM
Compound: Ellipticine
|
Cytotoxicity against human HEK293 cells by SRB method
Cytotoxicity against human HEK293 cells by SRB method
|
[PMID: 27793565] |
| HEK293 | ED50 |
2.27 μM
Compound: Ellipticine
|
Growth inhibition of human HEK293 cells after 72 hrs by SRB assay
Growth inhibition of human HEK293 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| HEK293 | IC50 |
1.9 μM
Compound: Ellipticine
|
Cytotoxicity against HEK293 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| HEK293 | IC50 |
1.69 μM
Compound: Ellipticine
|
Cytotoxicity against human HEK293 cells
Cytotoxicity against human HEK293 cells
|
[PMID: 33556568] |
| HEK293 | IC50 |
6.58 μM
Compound: Ellipticine
|
Cytotoxicity against human HEK293 cells assessed as cell viability measured by MTT assay
Cytotoxicity against human HEK293 cells assessed as cell viability measured by MTT assay
|
[PMID: 33895275] |
| HeLa | IC50 |
0.29 μM
Compound: Ellipticine
|
Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
Antiproliferative activity against human HeLa cells after 72 hrs by trypan blue assay
|
[PMID: 19155103] |
| HeLa | IC50 |
0.4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human HeLa cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265396] |
| HeLa | IC50 |
0.29 μM
Compound: ellipticine
|
Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay
Cytotoxicity against human HeLa cells after 72 hrs by trypan blue assay
|
[PMID: 19725581] |
| HeLa | IC50 |
0.31 μM
Compound: Ellipticine
|
Growth inhibition in human HeLa cells after 72 hrs by trypan blue assay
Growth inhibition in human HeLa cells after 72 hrs by trypan blue assay
|
[PMID: 21216603] |
| HeLa | GI50 |
3.28 μM
Compound: Ellipticine
|
Growth inhibition of human HeLa cells after 48 hrs by SRB assay
Growth inhibition of human HeLa cells after 48 hrs by SRB assay
|
[PMID: 24121236] |
| HeLa | GI50 |
0.3 μM
Compound: Ellipticine
|
Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay
Growth inhibition of human HeLa cells after 72 hrs by trypan blue assay
|
[PMID: 24631729] |
| HeLa | IC50 |
1 μM
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells assessed as growth inhibition by MTT assay
Cytotoxicity against human HeLa cells assessed as growth inhibition by MTT assay
|
[PMID: 26599533] |
| HeLa | IC50 |
1.6 μM
Compound: Ellipticine
|
Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human HeLa cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| HeLa | GI50 |
0.47 μM
Compound: Ellipticine
|
Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay
Growth inhibition in human HeLa cells after 72 hrs by trypan blue dye-based assay
|
[PMID: 30660826] |
| HeLa | IC50 |
2 μM
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by MTS assay
Cytotoxicity against human HeLa cells assessed as inhibition of cell proliferation measured after 48 hrs by MTS assay
|
[PMID: 31411887] |
| HeLa | IC50 |
1.05 μM
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34838335] |
| HeLa | IC50 |
9.85 μM
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human HeLa cells assessed as cell growth inhibition by MTT assay
|
[PMID: 34838335] |
| HeLa | IC50 |
9.81 μM
Compound: Ellipticine
|
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
|
10.1039/C2MD20335A |
| HeLa S3 | IC50 |
2.1 μM
Compound: 21
|
Cytotoxicity against human HeLaS3 cells assessed as cell viability after 24 to 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells assessed as cell viability after 24 to 72 hrs by MTT assay
|
[PMID: 24863982] |
| HeLa S3 | IC50 |
2.1 μM
Compound: 1
|
Cytotoxicity against human HeLaS3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HeLaS3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28063783] |
| HEp-2 | IC50 |
0.4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Hep2 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Hep2 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265396] |
| HEp-2 | IC50 |
9.85 μM
Compound: Ellipticine
|
Cytotoxicity against human HEp-2 cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human HEp-2 cells assessed as cell growth inhibition by MTT assay
|
[PMID: 34838335] |
| Hepatocyte | GI50 |
3.3 μM
Compound: Ellipticine
|
Growth inhibition of porcine primary hepatocytes after 72 hrs by SRB assay
Growth inhibition of porcine primary hepatocytes after 72 hrs by SRB assay
|
[PMID: 22014996] |
| HepG2 | GI50 |
2.9 μM
Compound: Ellipticine
|
Growth inhibition of human HepG2 cells after 72 hrs by SRB assay
Growth inhibition of human HepG2 cells after 72 hrs by SRB assay
|
[PMID: 22014996] |
| HepG2 | GI50 |
5.38 μM
Compound: Ellipticine
|
Growth inhibition of human HepG2 cells after 48 hrs by SRB assay
Growth inhibition of human HepG2 cells after 48 hrs by SRB assay
|
[PMID: 24121236] |
| HepG2 | IC50 |
1.26 nM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 3 days by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of cell growth after 3 days by MTT assay
|
[PMID: 24745968] |
| HepG2 | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 25442310] |
| HepG2 | IC50 |
1.26 nM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell growth after 3 days by MTT assay
|
[PMID: 25442315] |
| HepG2 | IC50 |
3.5 μM
Compound: Ellipticine
|
Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human HepG2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| HepG2 | IC50 |
1.3 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 26081288] |
| HepG2 | IC50 |
1.71 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
Cytotoxicity against human HepG2 cells after 48 hrs by SRB assay
|
[PMID: 26099533] |
| HepG2 | IC50 |
0.36 μg/mL
Compound: Ellipticine
|
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
|
[PMID: 26459207] |
| HepG2 | IC50 |
1.5 μM
Compound: EC
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
|
[PMID: 26516994] |
| HepG2 | IC50 |
2.07 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
|
[PMID: 26522953] |
| HepG2 | IC50 |
2.9 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition by MTT assay
|
[PMID: 26599533] |
| HepG2 | IC50 |
1.46 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as growth inhibition measured after 3 days by MTT assay
Cytotoxicity against human HepG2 cells assessed as growth inhibition measured after 3 days by MTT assay
|
[PMID: 27342752] |
| HepG2 | IC50 |
1.95 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| HepG2 | IC50 |
1.38 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
Cytotoxicity against human HepG2 cells after 72 hrs by SRB assay
|
[PMID: 28512032] |
| HepG2 | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity in human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human HepG2 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| HepG2 | IC50 |
2.72 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
Cytotoxicity against human HepG2 cells after 3 days by MTT assay
|
[PMID: 30337229] |
| HepG2 | IC50 |
0.93 μM
Compound: Ellipticine
|
Antiproliferative activity against human HepG2 cells by MTT assay
Antiproliferative activity against human HepG2 cells by MTT assay
|
[PMID: 31546197] |
| HepG2 | IC50 |
0.93 μM
Compound: Ellipticine
|
Antiproliferative activity against human HepG2 cells
Antiproliferative activity against human HepG2 cells
|
[PMID: 31945642] |
| HepG2 | IC50 |
0.85 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 32717612] |
| HepG2 | IC50 |
1.66 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
|
[PMID: 33556568] |
| HepG2 | IC50 |
1.34 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as cell viability measured by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability measured by MTT assay
|
[PMID: 33895275] |
| HepG2 | IC50 |
1.05 μM
Compound: Ellipticine
|
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34838335] |
| HL-60 | IC50 |
2.6 μM
Compound: ellipticine
|
Cytotoxicity against human HL60 cells after 3 days by SRB assay
Cytotoxicity against human HL60 cells after 3 days by SRB assay
|
[PMID: 17035025] |
| HL-60 | IC50 |
5.8 μM
Compound: ellipticine
|
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
|
[PMID: 17498951] |
| HL-60 | IC50 |
0.66 μM
Compound: Ellipticine
|
Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay
Antiproliferative activity against human HL60 cells after 72 hrs by trypan blue assay
|
[PMID: 19155103] |
| HL-60 | IC50 |
0.66 μM
Compound: ellipticine
|
Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay
Cytotoxicity against human HL60 cells after 72 hrs by trypan blue assay
|
[PMID: 19725581] |
| HL-60 | IC50 |
5.8 μM
Compound: Ellipticine
|
Cytotoxicity against human HL60 cells
Cytotoxicity against human HL60 cells
|
[PMID: 21095131] |
| HL-60 | IC50 |
0.64 μM
Compound: Ellipticine
|
Growth inhibition in human HL60 cells after 72 hrs by trypan blue assay
Growth inhibition in human HL60 cells after 72 hrs by trypan blue assay
|
[PMID: 21216603] |
| HL-60 | IC50 |
5.8 μM
Compound: Ellipticine
|
Cytotoxicity against human HL60 cells by MTT assay
Cytotoxicity against human HL60 cells by MTT assay
|
[PMID: 21353568] |
| HL-60 | GI50 |
2 μM
Compound: Ellipticine
|
Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay
Growth inhibition of human HL60 cells after 72 hrs by trypan blue assay
|
[PMID: 24631729] |
| HL-60 | IC50 |
2.93 μM
Compound: Ellipticine
|
Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human HL60 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| HL-60 | IC50 |
2 μM
Compound: Ellipticine
|
Cytotoxicity in human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human HL60 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| HL-60 | IC50 |
1.7 μM
Compound: Ellipticine
|
Antiproliferative activity against human HL60 cells by MTT assay
Antiproliferative activity against human HL60 cells by MTT assay
|
[PMID: 31546197] |
| HL-60 | IC50 |
1.7 μM
Compound: Ellipticine
|
Anticancer activity against human HL-60 cells
Anticancer activity against human HL-60 cells
|
[PMID: 31945642] |
| HT-1080 | IC50 |
5.01 μM
Compound: ellipticine
|
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
Cytotoxicity against human HT1080 cells after 3 days by SRB assay
|
[PMID: 17035025] |
| HT-1080 | IC50 |
4.3 μM
Compound: ellipticine
|
Cytotoxicity against human HT1080 cells by SRB assay
Cytotoxicity against human HT1080 cells by SRB assay
|
[PMID: 17498951] |
| HT-1080 | IC50 |
4.3 μM
Compound: Ellipticine
|
Cytotoxicity against human HT1080 cells
Cytotoxicity against human HT1080 cells
|
[PMID: 21095131] |
| HT-1080 | IC50 |
0.21 μM
Compound: Ellipticine
|
Cytotoxicity against human HT1080 cells after 6 days by SRB assay
Cytotoxicity against human HT1080 cells after 6 days by SRB assay
|
[PMID: 21330015] |
| HT-1080 | IC50 |
4.3 μM
Compound: Ellipticine
|
Cytotoxicity against human HT1080 cells by MTT assay
Cytotoxicity against human HT1080 cells by MTT assay
|
[PMID: 21353568] |
| HT-29 | IC50 |
15 μM
Compound: Ellipticine
|
In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
In vitro cytotoxic activity against human colon HT-29 cell line ( standard deviation in parenthesis)
|
[PMID: 12036369] |
| HT-29 | IC50 |
14.9 μM
Compound: ellipticine
|
Cytotoxicity against human HT29 cell line
Cytotoxicity against human HT29 cell line
|
[PMID: 17228871] |
| HT-29 | ED50 |
2.43 μM
Compound: Ellipticine
|
Cytotoxicity against human HT-29 cells by SRB method
Cytotoxicity against human HT-29 cells by SRB method
|
[PMID: 27793565] |
| HT-29 | IC50 |
2.06 μM
Compound: Ellipticine
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 28755636] |
| HT-29 | ED50 |
2.68 μM
Compound: Ellipticine
|
Growth inhibition of human HT-29 cells after 72 hrs by SRB assay
Growth inhibition of human HT-29 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| HT-29 | IC50 |
2 μM
Compound: Ellipticine
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| HT-29 | IC50 |
2.16 μM
Compound: Ellipticine
|
Anticancer activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Anticancer activity against human HT-29 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 32527561] |
| HT-29 | IC50 |
2.59 μM
Compound: Ellipticine
|
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 33316411] |
| HT-29 | IC50 |
1.95 μM
Compound: Ellipticine
|
Cytotoxicity against human HT-29 cells assessed as growth inhibition measured by SRB assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition measured by SRB assay
|
[PMID: 34044119] |
| HuCC-A1 | ED50 |
3.46 μM
Compound: Ellipticine
|
Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay
Growth inhibition of human HuCCa1 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| HuCC-A1 | IC50 |
2.43 μM
Compound: Ellipticine
|
Anticancer activity against human HuCCa1 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Anticancer activity against human HuCCa1 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 32527561] |
| HUVEC | IC50 |
0.37 μM
Compound: ellipticine
|
Cytotoxicity against HUVEC
Cytotoxicity against HUVEC
|
[PMID: 14987058] |
| IGROV-1 | GI50 |
0.862 μM
Compound: 1
|
Tested in vitro for cytotoxicity in IGROV1 cell lines
Tested in vitro for cytotoxicity in IGROV1 cell lines
|
[PMID: 8035426] |
| IGROV-1 | GI50 |
0.86 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of ovarian cancer IGROVI cells
Cytotoxic effect on growth inhibition of ovarian cancer IGROVI cells
|
[PMID: 8765520] |
| Ishikawa | IC50 |
1.5 μM
Compound: Ellipticine
|
Cytotoxicity against human Ishikawa cells assessed as growth inhibition by MTT assay
Cytotoxicity against human Ishikawa cells assessed as growth inhibition by MTT assay
|
[PMID: 26599533] |
| Ishikawa | IC50 |
1.05 μM
Compound: Ellipticine
|
Cytotoxicity against human Ishikawa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human Ishikawa cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34838335] |
| K562 | IC50 |
0.38 μM
Compound: Ellipticine
|
Cytotoxicity against human K562 cells after 6 days by SRB assay
Cytotoxicity against human K562 cells after 6 days by SRB assay
|
[PMID: 21330015] |
| KB | ED50 |
0.33 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by SRB method
Cytotoxicity against human KB cells after 72 hrs by SRB method
|
[PMID: 10479311] |
| KB | IC50 |
0.1 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 11277765] |
| KB | IC50 |
0.46 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 11520217] |
| KB | IC50 |
0.3 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 12350163] |
| KB | IC50 |
0.3 μg/mL
Compound: Ellipticine
|
Cytotoxicity against KB cell line
Cytotoxicity against KB cell line
|
[PMID: 12657257] |
| KB | ED50 |
0.04 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 12762797] |
| KB | IC50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 12828479] |
| KB | IC50 |
0.16 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 14987058] |
| KB | IC50 |
0.2 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 15043440] |
| KB | IC50 |
0.4 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 15217275] |
| KB | IC50 |
0.36 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 15730240] |
| KB | IC50 |
0.26 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 16038539] |
| KB | IC50 |
0.8 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 16038559] |
| KB | IC50 |
0.21 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 16309322] |
| KB | IC50 |
0.3 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by colorimetric assay
Cytotoxicity against human KB cells by colorimetric assay
|
[PMID: 16378377] |
| KB | IC50 |
0.36 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 16441071] |
| KB | IC50 |
0.24 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by MTT assay
Cytotoxicity against human KB cells by MTT assay
|
[PMID: 16792425] |
| KB | IC50 |
2.4 μM
Compound: elliptecine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 16919455] |
| KB | IC50 |
8.12 x 10-4 M
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 16933890] |
| KB | IC50 |
8.12 x 10-4 mM
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 16933890] |
| KB | IC50 |
0.21 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 16989536] |
| KB | IC50 |
5.41 μM
Compound: Ellipticin
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 17067151] |
| KB | ED50 |
1.31 μg/mL
Compound: Ellipticine
|
Toxicity against human KB cells
Toxicity against human KB cells
|
[PMID: 17067158] |
| KB | ED50 |
0.65 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 17190450] |
| KB | IC50 |
5.3 μM
Compound: ellipticine
|
Cytotoxicity against KB cells by colorimetric method
Cytotoxicity against KB cells by colorimetric method
|
[PMID: 17480099] |
| KB | IC50 |
0.67 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 17567069] |
| KB | IC50 |
0.36 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 17845001] |
| KB | IC50 |
0.41 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 18179177] |
| KB | ED50 |
0.7 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
|
[PMID: 18271551] |
| KB | IC50 |
1.99 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 18363379] |
| KB | IC50 |
2.2 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells by colorimetric method
Cytotoxicity against human KB cells by colorimetric method
|
[PMID: 18380478] |
| KB | IC50 |
0.4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
|
[PMID: 19265396] |
| KB | IC50 |
1.38 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 19265430] |
| KB | IC50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by sulforhodamine B assay
Cytotoxicity against human KB cells by sulforhodamine B assay
|
[PMID: 19368377] |
| KB | IC50 |
0.37 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by sulforhodamine B assay
Cytotoxicity against human KB cells by sulforhodamine B assay
|
[PMID: 19555123] |
| KB | IC50 |
0.36 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 19627125] |
| KB | IC50 |
0.36 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 19663417] |
| KB | IC50 |
2.5 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
|
[PMID: 19739600] |
| KB | IC50 |
0.48 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 19778068] |
| KB | IC50 |
0.45 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
|
[PMID: 20329738] |
| KB | IC50 |
1.79 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay
Cytotoxicity against human KB cells after 3 days by Resazurin Microplate Assay
|
[PMID: 20362442] |
| KB | IC50 |
2.5 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay
Cytotoxicity against human KB cells after 45 hrs by resazurin microplate assay
|
[PMID: 20364867] |
| KB | IC50 |
1.1 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 20815366] |
| KB | IC50 |
1.79 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
|
[PMID: 21302964] |
| KB | IC50 |
0.19 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells by sulforhodamine B assay
Cytotoxicity against human KB cells by sulforhodamine B assay
|
[PMID: 21341709] |
| KB | IC50 |
1.78 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 3 days by resazurin microplate assay
Cytotoxicity against human KB cells after 3 days by resazurin microplate assay
|
[PMID: 21641693] |
| KB | IC50 |
1.25 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 22004007] |
| KB | ED50 |
2.46 μM
Compound: Ellipt
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 22154665] |
| KB | IC50 |
5.2 μM
Compound: ellipticine
|
Cytotoxicity against human KB cells by resazurin reduction assay
Cytotoxicity against human KB cells by resazurin reduction assay
|
[PMID: 22482432] |
| KB | ED50 |
2.2 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human KB cells after 72 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| KB | IC50 |
1.19 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB assay
Cytotoxicity against human KB cells by SRB assay
|
[PMID: 23806014] |
| KB | IC50 |
4.87 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by resazurin assay
Cytotoxicity against human KB cells by resazurin assay
|
[PMID: 23806072] |
| KB | IC50 |
1.26 nM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as inhibition of cell growth after 3 days by MTT assay
Cytotoxicity against human KB cells assessed as inhibition of cell growth after 3 days by MTT assay
|
[PMID: 24745968] |
| KB | IC50 |
2.25 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
Cytotoxicity against human KB cells assessed as growth inhibition by resazurin microplate assay
|
[PMID: 24857542] |
| KB | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 25442310] |
| KB | IC50 |
1.26 nM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human KB cells assessed as reduction in cell growth after 3 days by MTT assay
|
[PMID: 25442315] |
| KB | IC50 |
1.98 μM
Compound: ellipticine
|
Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
Antiproliferative activity against human KB cells assessed as reduction in cell growth incubated at 37 degC for 3 days by resazurin microplate assay
|
[PMID: 25734623] |
| KB | IC50 |
3.98 μM
Compound: Ellipticine
|
Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human KB cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| KB | IC50 |
1.3 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 26081288] |
| KB | IC50 |
2.07 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 48 hrs by SRB assay
Cytotoxicity against human KB cells after 48 hrs by SRB assay
|
[PMID: 26099533] |
| KB | IC50 |
1.4 μM
Compound: EC
|
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
Cytotoxicity against human KB cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
|
[PMID: 26516994] |
| KB | IC50 |
1.66 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
|
[PMID: 26522953] |
| KB | IC50 |
2.03 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by resazurin microplate assay
Cytotoxicity against human KB cells by resazurin microplate assay
|
[PMID: 27228159] |
| KB | IC50 |
8.28 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 27311894] |
| KB | IC50 |
1.26 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as growth inhibition measured after 3 days by MTT assay
Cytotoxicity against human KB cells assessed as growth inhibition measured after 3 days by MTT assay
|
[PMID: 27342752] |
| KB | IC50 |
0.52 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
|
[PMID: 27517802] |
| KB | ED50 |
2.03 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells by SRB method
Cytotoxicity against human KB cells by SRB method
|
[PMID: 27793565] |
| KB | IC50 |
1.79 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
|
[PMID: 28512032] |
| KB | IC50 |
1.87 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay
|
[PMID: 28755636] |
| KB | IC50 |
2.81 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by resazurin based fluorescence assay
Cytotoxicity against human KB cells after 72 hrs by resazurin based fluorescence assay
|
[PMID: 28927795] |
| KB | ED50 |
2.34 μM
Compound: Ellipticine
|
Growth inhibition of human KB cells after 72 hrs by SRB assay
Growth inhibition of human KB cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| KB | IC50 |
2.15 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| KB | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity in human KB cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human KB cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| KB | IC50 |
1.95 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 3 days by MTT assay
Cytotoxicity against human KB cells after 3 days by MTT assay
|
[PMID: 30337229] |
| KB | IC50 |
8.2 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 30860372] |
| KB | IC50 |
0.81 μM
Compound: Ellipticine
|
Antiproliferative activity against human KB cells by MTT assay
Antiproliferative activity against human KB cells by MTT assay
|
[PMID: 31546197] |
| KB | IC50 |
0.81 μM
Compound: Ellipticine
|
Antiproliferative activity against human KB cells
Antiproliferative activity against human KB cells
|
[PMID: 31945642] |
| KB | IC50 |
1.92 μM
Compound: Ellipticine
|
Anticancer activity against human KB cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Anticancer activity against human KB cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 32527561] |
| KB | IC50 |
2.2 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by SRB assay
|
[PMID: 33316411] |
| KB | IC50 |
1.75 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 33556568] |
| KB | IC50 |
6.1 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin based fluorescence assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin based fluorescence assay
|
[PMID: 33852304] |
| KB | IC50 |
1.26 μM
Compound: Ellipticine
|
Cytotoxicity against human KB cells assessed as cell viability measured by MTT assay
Cytotoxicity against human KB cells assessed as cell viability measured by MTT assay
|
[PMID: 33895275] |
| KB | ED50 |
0.36 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 7130986] |
| KB | ED50 |
0.04 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human KB cells after 3 days by SRB assay
Cytotoxicity against human KB cells after 3 days by SRB assay
|
[PMID: 7528785] |
| KB | ED50 |
0.1 μg/mL
Compound: ellipticine
|
Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
|
[PMID: 9917280] |
| L1210 | IC50 |
0.19 μM
Compound: ellipticine
|
Cytotoxicity against mouse L1210 cell line
Cytotoxicity against mouse L1210 cell line
|
[PMID: 17228871] |
| L1210 | ED50 |
0.85 μM
Compound: 19
|
The effective dose against L1210 cell growth
The effective dose against L1210 cell growth
|
[PMID: 4009597] |
| L1210 | IC50 |
0.5 μM
Compound: Ellipticine
|
The compound was tested in vitro for growth inhibitory activity against murine leukemia L1210 cells
The compound was tested in vitro for growth inhibitory activity against murine leukemia L1210 cells
|
10.1016/S0960-894X(97)10138-X |
| LCLC-103H cell line | IC50 |
0.8 μM
Compound: 1, Ellipticine
|
Cytotoxicity against human LCLC-103H cells after 96 hrs by crystal violet staining
Cytotoxicity against human LCLC-103H cells after 96 hrs by crystal violet staining
|
[PMID: 19481463] |
| LNCaP | ED50 |
0.8 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 12762797] |
| LNCaP | IC50 |
3.25 μM
Compound: ellipticine
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 14987058] |
| LNCaP | IC50 |
3.21 μM
Compound: Ellipticine
|
Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human LNCAP cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| LNCaP | IC50 |
1.99 μM
Compound: Ellipticine
|
Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
Cytotoxicity against human LNCAP cells after 48 hrs by SRB assay
|
[PMID: 26099533] |
| LNCaP | IC50 |
1.95 μM
Compound: Ellipticine
|
Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay
Cytotoxicity against human LNCAP cells after 72 hrs by SRB assay
|
[PMID: 28512032] |
| LNCaP | ED50 |
0.8 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
Cytotoxicity against human LNCAP cells after 3 days by SRB assay
|
[PMID: 7528785] |
| LOX IMVI | GI50 |
0.56 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of melanoma LOX IMVI cells
Cytotoxic effect on growth inhibition of melanoma LOX IMVI cells
|
[PMID: 8765520] |
| Lu1 | ED50 |
0.02 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 12762797] |
| Lu1 | IC50 |
0.08 μM
Compound: ellipticine
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 14987058] |
| Lu1 | ED50 |
0.56 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells by SRB assay
Cytotoxicity against human Lu1 cells by SRB assay
|
[PMID: 17190450] |
| Lu1 | ED50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 18271551] |
| Lu1 | ED50 |
1.62 μM
Compound: Ellipt
|
Cytotoxicity against human Lu1 cells by SRB assay
Cytotoxicity against human Lu1 cells by SRB assay
|
[PMID: 22154665] |
| Lu1 | ED50 |
1.1 μM
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human Lu1 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| Lu1 | IC50 |
2.72 μM
Compound: Ellipticine
|
Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human Lu1 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| Lu1 | IC50 |
1.2 μM
Compound: EC
|
Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
Cytotoxicity against human Lu1 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
|
[PMID: 26516994] |
| Lu1 | IC50 |
2.31 μM
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay
Cytotoxicity against human Lu1 cells after 72 hrs by SRB assay
|
[PMID: 26522953] |
| Lu1 | IC50 |
1.39 μM
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells after 3 days by MTT assay
Cytotoxicity against human Lu1 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| Lu1 | IC50 |
1.6 μM
Compound: Ellipticine
|
Cytotoxicity in human Lu1 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human Lu1 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| Lu1 | IC50 |
1.7 μM
Compound: Ellipticine
|
Antiproliferative activity against human Lu1 cells by MTT assay
Antiproliferative activity against human Lu1 cells by MTT assay
|
[PMID: 31546197] |
| Lu1 | ED50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human Lu1 cells after 3 days by SRB assay
Cytotoxicity against human Lu1 cells after 3 days by SRB assay
|
[PMID: 7528785] |
| Malme-3M | GI50 |
2.52 μM
Compound: 1
|
Tested in vitro for cytotoxicity in MALME-3M
Tested in vitro for cytotoxicity in MALME-3M
|
[PMID: 8035426] |
| MCF-10A | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF10A cells assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human MCF10A cells assessed as cell viability after 5 days by MTT assay
|
[PMID: 26599533] |
| MCF-10A | IC50 |
1.2 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 31400710] |
| MCF7 | ED50 |
0.4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 18271551] |
| MCF7 | IC50 |
0.43 μM
Compound: 1, Ellipticine
|
Cytotoxicity against human MCF7 cells after 96 hrs by crystal violet staining
Cytotoxicity against human MCF7 cells after 96 hrs by crystal violet staining
|
[PMID: 19481463] |
| MCF7 | IC50 |
1.6 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 20667744] |
| MCF7 | IC50 |
1.6 μM
Compound: Ellipticine
|
Antitumor activity against human MCF7 cells after 72 hrs by MTT assay
Antitumor activity against human MCF7 cells after 72 hrs by MTT assay
|
[PMID: 21458275] |
| MCF7 | ED50 |
2.71 μM
Compound: Ellipt
|
Cytotoxicity against human MCF7 cells by SRB assay
Cytotoxicity against human MCF7 cells by SRB assay
|
[PMID: 22154665] |
| MCF7 | ED50 |
2.3 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against human MCF7 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| MCF7 | GI50 |
4.32 μM
Compound: Ellipticine
|
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
Growth inhibition of human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 24121236] |
| MCF7 | IC50 |
2.15 nM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 3 days by MTT assay
|
[PMID: 24745968] |
| MCF7 | IC50 |
2.1 nM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
|
[PMID: 25442315] |
| MCF7 | IC50 |
1.8 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
|
[PMID: 26081288] |
| MCF7 | IC50 |
1.95 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay
|
[PMID: 26099533] |
| MCF7 | IC50 |
0.44 μg/mL
Compound: Ellipticine
|
Antiproliferative activity against human MCF7 cells
Antiproliferative activity against human MCF7 cells
|
[PMID: 26459207] |
| MCF7 | IC50 |
0.9 μM
Compound: EC
|
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
|
[PMID: 26516994] |
| MCF7 | IC50 |
1.54 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
|
[PMID: 26522953] |
| MCF7 | IC50 |
1.25 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by MTT assay
|
[PMID: 26599533] |
| MCF7 | IC50 |
0.53 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
Cytotoxicity against human MCF7 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| MCF7 | ED50 |
2.11 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells by SRB method
Cytotoxicity against human MCF7 cells by SRB method
|
[PMID: 27793565] |
| MCF7 | IC50 |
1.6 μM
Compound: Ellipticine
|
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine free medium assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
1.6 μM
Compound: Ellipticine
|
Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against vinblastine-sensitive human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
2 μM
Compound: Ellipticine
|
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
Cytotoxicity against multidrug resistant human MCF7 cells cultured in vinblastine containing medium assessed as growth inhibition after 72 hrs by SRB assay
|
[PMID: 28006904] |
| MCF7 | IC50 |
1.34 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
|
[PMID: 28512032] |
| MCF7 | IC50 |
1.53 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 28755636] |
| MCF7 | ED50 |
1.66 μM
Compound: Ellipticine
|
Growth inhibition of human MCF7 cells after 72 hrs by SRB assay
Growth inhibition of human MCF7 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| MCF7 | IC50 |
1.99 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| MCF7 | IC50 |
2.4 μM
Compound: Ellipticine
|
Cytotoxicity in human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
Cytotoxicity in human MCF7 cells assessed as reduction in cell growth incubated for 72 hrs by neutral red staining based colorimetry
|
[PMID: 30108762] |
| MCF7 | IC50 |
0.8 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 31120251] |
| MCF7 | IC50 |
1.25 μM
Compound: Ellipticine
|
Antiproliferative activity against ER-alpha positive human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against ER-alpha positive human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 31400710] |
| MCF7 | IC50 |
1.7 μM
Compound: Ellipticine
|
Antiproliferative activity against human MCF7 cells by MTT assay
Antiproliferative activity against human MCF7 cells by MTT assay
|
[PMID: 31546197] |
| MCF7 | IC50 |
1.7 μM
Compound: Ellipticine
|
Anticancer activity against human MCF7 cells
Anticancer activity against human MCF7 cells
|
[PMID: 31945642] |
| MCF7 | IC50 |
1.7 μM
Compound: Ellipticine
|
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth
Anticancer activity against human MCF7 cells assessed as inhibition of cell growth
|
[PMID: 31945642] |
| MCF7 | IC50 |
1.79 μM
Compound: Ellipticine
|
Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Anticancer activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 32527561] |
| MCF7 | IC50 |
2.18 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 33316411] |
| MCF7 | IC50 |
1.58 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells
Cytotoxicity against human MCF7 cells
|
[PMID: 33556568] |
| MCF7 | IC50 |
2.48 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as cell viability measured by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell viability measured by MTT assay
|
[PMID: 33895275] |
| MCF7 | IC50 |
1.05 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34838335] |
| MCF7 | IC50 |
9.85 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition by MTT assay
|
[PMID: 34838335] |
| MCF7 | GI50 |
0.71 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of breast cancer MCF-7 cells
Cytotoxic effect on growth inhibition of breast cancer MCF-7 cells
|
[PMID: 8765520] |
| MCF7 | GI50 |
0.74 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect of growth inhibition of breast cancer MCF-7/ADR-RES cells
Cytotoxic effect of growth inhibition of breast cancer MCF-7/ADR-RES cells
|
[PMID: 8765520] |
| MCF7 | IC50 |
16.72 μM
Compound: Ellipticine
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
10.1039/C2MD20335A |
| MDA-MB-231 | IC50 |
2.3 μM
Compound: Ellipticine
|
In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
In vitro cytotoxic activity against human breast MDA-MB-231 cell line ( standard deviation in parenthesis)
|
[PMID: 12036369] |
| MDA-MB-231 | IC50 |
3.21 μM
Compound: Ellipticine
|
Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| MDA-MB-231 | IC50 |
1.82 μM
Compound: Ellipticine
|
Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 5 days by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after 5 days by MTT assay
|
[PMID: 26599533] |
| MDA-MB-231 | IC50 |
0.1 μM
Compound: Ellipticine
|
Antiproliferative activity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human MDA-MB-231 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| MDA-MB-231 | IC50 |
1.85 μM
Compound: Ellipticine
|
Antiproliferative activity against triple negative human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Antiproliferative activity against triple negative human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 31400710] |
| MDA-MB-231 | IC50 |
2.03 μM
Compound: Ellipticine
|
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as growth inhibition measured by SRB assay
|
[PMID: 34044119] |
| MDA-MB-231 | IC50 |
1.05 μM
Compound: Ellipticine
|
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
|
[PMID: 34838335] |
| MKN-7 | IC50 |
3.82 μM
Compound: Ellipticine
|
Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human MKN7 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| MOLT-4 | GI50 |
0.38 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on leukemia MOLT-4 cells
Cytotoxic effect on leukemia MOLT-4 cells
|
[PMID: 8765520] |
| MRC5 | IC50 |
1.3 μM
Compound: Ellipticine
|
Antiproliferative activity against human MRC5 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human MRC5 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| MSTO-211H | GI50 |
0.77 μM
Compound: Ellipticine
|
Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay
Growth inhibition in human MSTO-211H cells after 72 hrs by trypan blue dye-based assay
|
[PMID: 30660826] |
| NCI-H1299 | IC50 |
0.6 μM
Compound: Ellipticine
|
Antiproliferative activity against human H1299 cells after 3 days by SRB assay
Antiproliferative activity against human H1299 cells after 3 days by SRB assay
|
[PMID: 21916433] |
| NCI-H187 | IC50 |
0.4 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 15217275] |
| NCI-H187 | IC50 |
0.32 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 15730240] |
| NCI-H187 | IC50 |
0.32 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
|
[PMID: 16038539] |
| NCI-H187 | IC50 |
0.8 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 16038559] |
| NCI-H187 | IC50 |
0.32 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 16309322] |
| NCI-H187 | IC50 |
0.3 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by colorimetric assay
Cytotoxicity against human NCI-H187 cells by colorimetric assay
|
[PMID: 16378377] |
| NCI-H187 | IC50 |
0.26 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 16441071] |
| NCI-H187 | IC50 |
1.9 μM
Compound: elliptecine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 16919455] |
| NCI-H187 | IC50 |
2.23 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 16933890] |
| NCI-H187 | IC50 |
2.23 x 10-3 M
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 16933890] |
| NCI-H187 | IC50 |
1.59 μM
Compound: Ellipticin
|
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
|
[PMID: 17067151] |
| NCI-H187 | IC50 |
0.32 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 17845001] |
| NCI-H187 | IC50 |
0.52 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells
Cytotoxicity against human NCI-H187 cells
|
[PMID: 18179177] |
| NCI-H187 | IC50 |
1.71 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
|
[PMID: 18363379] |
| NCI-H187 | IC50 |
2 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by colorimetric method
Cytotoxicity against human NCI-H187 cells by colorimetric method
|
[PMID: 18380478] |
| NCI-H187 | IC50 |
4.4 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 19265430] |
| NCI-H187 | IC50 |
0.3 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay
Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay
|
[PMID: 19368377] |
| NCI-H187 | IC50 |
0.44 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay
Cytotoxicity against human NCI-H187 cells by sulforhodamine B assay
|
[PMID: 19555123] |
| NCI-H187 | IC50 |
0.26 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 19627125] |
| NCI-H187 | IC50 |
0.32 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 19663417] |
| NCI-H187 | IC50 |
3.6 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
|
[PMID: 19739600] |
| NCI-H187 | IC50 |
0.44 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 19778068] |
| NCI-H187 | IC50 |
0.68 μg/mL
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
|
[PMID: 20329738] |
| NCI-H187 | IC50 |
2.77 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay
Cytotoxicity against human NCI-H187 cells after 5 days by Resazurin Microplate Assay
|
[PMID: 20362442] |
| NCI-H187 | IC50 |
1.5 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells after 45 hrs by resazurin microplate assay
|
[PMID: 20364867] |
| NCI-H187 | IC50 |
2.76 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 by resazurin microplate assay
Cytotoxicity against human NCI-H187 by resazurin microplate assay
|
[PMID: 21302964] |
| NCI-H187 | IC50 |
2.77 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells after 5 days by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells after 5 days by resazurin microplate assay
|
[PMID: 21641693] |
| NCI-H187 | IC50 |
1.82 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 22004007] |
| NCI-H187 | IC50 |
3.1 μM
Compound: ellipticine
|
Cytotoxicity against human NCI-H187 cells by resazurin reduction assay
Cytotoxicity against human NCI-H187 cells by resazurin reduction assay
|
[PMID: 22482432] |
| NCI-H187 | IC50 |
1.16 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by SRB assay
Cytotoxicity against human NCI-H187 cells by SRB assay
|
[PMID: 23806014] |
| NCI-H187 | IC50 |
0.95 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells after 72 hrs by resazurin based fluorescence assay
Cytotoxicity against human NCI-H187 cells after 72 hrs by resazurin based fluorescence assay
|
[PMID: 28927795] |
| NCI-H187 | IC50 |
9.3 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells by resazurin microplate assay
|
[PMID: 32193929] |
| NCI-H187 | IC50 |
9.1 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin based fluorescence assay
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin based fluorescence assay
|
[PMID: 33852304] |
| NCI-H187 | IC50 |
13.7 μM
Compound: Ellipticine
|
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human NCI-H187 cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 34748348] |
| NCI-H1993 | IC50 |
0.2 μM
Compound: Ellipticine
|
Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay
|
[PMID: 21916433] |
| NCI-H292 | IC50 |
1 μM
Compound: Ellipticine
|
Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay
|
[PMID: 21916433] |
| NCI-H322M | GI50 |
0.31 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of nonsmall cell lung cancer NCI-H322M cells
Cytotoxic effect on growth inhibition of nonsmall cell lung cancer NCI-H322M cells
|
[PMID: 8765520] |
| NCI-H358 | IC50 |
0.2 μM
Compound: 1 (ellipticin)
|
Compound was evaluated for inhibitory activity against H 358 human lung cancer cell line
Compound was evaluated for inhibitory activity against H 358 human lung cancer cell line
|
[PMID: 1479585] |
| NCI-H358 | IC50 |
0.8 μM
Compound: Ellipticine
|
Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay
|
[PMID: 21916433] |
| NCI-H417 | IC50 |
0.87 μM
Compound: 1 (ellipticin)
|
Compound was evaluated for inhibitory activity against N 417 human lung cancer cell line
Compound was evaluated for inhibitory activity against N 417 human lung cancer cell line
|
[PMID: 1479585] |
| NCI-H460 | IC50 |
0.51 μM
Compound: 1 (ellipticin)
|
Compound was evaluated for inhibitory activity against H 460 human lung cancer cell line
Compound was evaluated for inhibitory activity against H 460 human lung cancer cell line
|
[PMID: 1479585] |
| NCI-H460 | GI50 |
5.77 μM
Compound: Ellipticine
|
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
Growth inhibition of human NCI-H460 cells after 48 hrs by SRB assay
|
[PMID: 24121236] |
| NCI-H69 | IC50 |
1.8 μM
Compound: 1 (ellipticin)
|
Compound was evaluated for inhibitory activity against H69 human lung cancer cell line
Compound was evaluated for inhibitory activity against H69 human lung cancer cell line
|
[PMID: 1479585] |
| NHDF | IC50 |
>10 μM
Compound: Ellipticine
|
Antitumor activity against human NHDF cells after 72 hrs by MTT assay
Antitumor activity against human NHDF cells after 72 hrs by MTT assay
|
[PMID: 21458275] |
| NIH3T3 | IC50 |
0.003 μM
Compound: 1, Ellipticine
|
Growth inhibition of mouse NIH3T3 cells by MTT assay
Growth inhibition of mouse NIH3T3 cells by MTT assay
|
[PMID: 17376678] |
| NIH3T3 | IC50 |
1.3 μM
Compound: EC
|
Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
Cytotoxicity against mouse NIH/3T3 cells assessed as growth inhibition after 72 hrs by neutral red staining based colorimetric assay
|
[PMID: 26516994] |
| NIH3T3 | IC50 |
0.32 μM
Compound: Ellipticine
|
Cytotoxicity against mouse NIH/3T3 cells after 3 days by MTT assay
Cytotoxicity against mouse NIH/3T3 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| NIH3T3 | IC50 |
0.3 μM
Compound: 1
|
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse NIH/3T3 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28063783] |
| OVCAR | ED50 |
0.58 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human OVCAR cells after 72 hrs by SRB method
Cytotoxicity against human OVCAR cells after 72 hrs by SRB method
|
[PMID: 10479311] |
| P338 | IC50 |
0.44 μg/mL
Compound: Ellipticine
|
Antiproliferative activity against mouse P338 cells
Antiproliferative activity against mouse P338 cells
|
[PMID: 26459207] |
| P338 | IC50 |
1.27 μM
Compound: Ellipticine
|
Cytotoxicity against mouse P338 cells after 3 days by MTT assay
Cytotoxicity against mouse P338 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| P388 | ED50 |
<1 μg/mL
Compound: Ellipticine
|
Toxicity against mouse P388 cells
Toxicity against mouse P388 cells
|
[PMID: 17067158] |
| P388 | ED50 |
0.52 μg/mL
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells by SRB assay
Cytotoxicity against mouse P388 cells by SRB assay
|
[PMID: 17190450] |
| P388 | ED50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells after 72 hrs by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 72 hrs by sulforhodamine B assay
|
[PMID: 18271551] |
| P388 | ED50 |
2.44 μM
Compound: Ellipt
|
Cytotoxicity against mouse P388 cells by SRB assay
Cytotoxicity against mouse P388 cells by SRB assay
|
[PMID: 22154665] |
| P388 | ED50 |
1.9 μM
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 23550966] |
| P388 | ED50 |
2.15 μM
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells by SRB method
Cytotoxicity against mouse P388 cells by SRB method
|
[PMID: 27793565] |
| P388 | IC50 |
1.34 μM
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by SRB assay
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by SRB assay
|
[PMID: 28755636] |
| P388 | ED50 |
2.12 μM
Compound: Ellipticine
|
Growth inhibition of mouse P388 cells after 72 hrs by SRB assay
Growth inhibition of mouse P388 cells after 72 hrs by SRB assay
|
[PMID: 29097170] |
| P388 | IC50 |
1.84 μM
Compound: Ellipticine
|
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by Sulforhodamine B assay
Cytotoxicity against mouse P388 cells assessed as reduction in cell viability by Sulforhodamine B assay
|
[PMID: 29606574] |
| P388 | IC50 |
1.7 μM
Compound: Ellipticine
|
Antiproliferative activity against mouse P388 cells by MTT assay
Antiproliferative activity against mouse P388 cells by MTT assay
|
[PMID: 31546197] |
| P388 | IC50 |
1.7 μM
Compound: Ellipticine
|
Anticancer activity against mouse P388 cells
Anticancer activity against mouse P388 cells
|
[PMID: 31945642] |
| P388 | IC50 |
1.79 μM
Compound: Ellipticine
|
Anticancer activity against mouse P388 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
Anticancer activity against mouse P388 cells assessed as reduction in cell viability measured after 48 hrs by SRB assay
|
[PMID: 32527561] |
| R1 | IC50 |
90 μM
Compound: 3
|
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
Inhibition of glucocorticoid receptor-glucocorticoid complex transfected in rat R1 cells assessed as down-regulation of TPA-responsive element proinflammatory gene expression after 24 hrs by beta-galactosidase assay
|
[PMID: 18412397] |
| RT-4 | IC50 |
1.21 μM
Compound: 1, Ellipticine
|
Cytotoxicity against human RT4 cells after 96 hrs by crystal violet staining
Cytotoxicity against human RT4 cells after 96 hrs by crystal violet staining
|
[PMID: 19481463] |
| Sarcoma-180 | IC50 |
2 μM
Compound: 1
|
Cytotoxicity against mouse Sarcoma 180 cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse Sarcoma 180 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
[PMID: 28063783] |
| SF-268 | GI50 |
0.816 μM
Compound: 1
|
Tested in vitro for cytotoxicity in SF-268 cell lines
Tested in vitro for cytotoxicity in SF-268 cell lines
|
[PMID: 8035426] |
| SH-SY5Y | IC50 |
2.13 μM
Compound: Ellipticine
|
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured by SRB assay
Cytotoxicity against human SH-SY5Y cells assessed as growth inhibition measured by SRB assay
|
[PMID: 34044119] |
| SK-HEP1 | IC50 |
0.4 μM
Compound: Ellipticine
|
Antiproliferative activity against human SKHEP1 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human SKHEP1 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| SK-LU-1 | IC50 |
1.38 μM
Compound: Ellipticine
|
Cytotoxicity against human SK-LU-1 cells after 3 days by MTT assay
Cytotoxicity against human SK-LU-1 cells after 3 days by MTT assay
|
[PMID: 30337229] |
| SK-LU-1 | IC50 |
1.54 μM
Compound: Ellipticine
|
Cytotoxicity against human SK-LU-1 cells
Cytotoxicity against human SK-LU-1 cells
|
[PMID: 33556568] |
| SK-MEL-2 | IC50 |
1.14 μM
Compound: Ellipticine
|
Cytotoxic activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human SK-MEL-2 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| SK-MEL-2 | IC50 |
2.15 μM
Compound: Ellipticine
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
|
[PMID: 26099533] |
| SK-MEL-2 | IC50 |
1.91 μM
Compound: Ellipticine
|
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 72 hrs by SRB assay
|
[PMID: 28512032] |
| SK-MES-1 | IC50 |
0.2 μM
Compound: Ellipticine
|
Antiproliferative activity against human SK-MES cells after 3 days by SRB assay
Antiproliferative activity against human SK-MES cells after 3 days by SRB assay
|
[PMID: 21916433] |
| SN12C | GI50 |
0.73 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of renal cancer SN12C cells
Cytotoxic effect on growth inhibition of renal cancer SN12C cells
|
[PMID: 8765520] |
| SNU-638 | IC50 |
2 μM
Compound: Ellipticine
|
In vitro cytotoxicity against human SNU-638 (stomach cancer) cell line.
In vitro cytotoxicity against human SNU-638 (stomach cancer) cell line.
|
[PMID: 15177438] |
| SNU-638 | IC50 |
5.97 μM
Compound: ellipticine
|
Cytotoxicity against human SNU638 cells after 3 days by SRB assay
Cytotoxicity against human SNU638 cells after 3 days by SRB assay
|
[PMID: 17035025] |
| SNU-638 | IC50 |
2.2 μM
Compound: ellipticine
|
Cytotoxicity against human SNU638 cells by SRB assay
Cytotoxicity against human SNU638 cells by SRB assay
|
[PMID: 17498951] |
| SNU-638 | IC50 |
2.2 μM
Compound: Ellipticine
|
Cytotoxicity against human SNU638 cells
Cytotoxicity against human SNU638 cells
|
[PMID: 21095131] |
| SNU-638 | IC50 |
1.64 μM
Compound: Ellipticine
|
Cytotoxicity against human SNU638 cells after 6 days by SRB assay
Cytotoxicity against human SNU638 cells after 6 days by SRB assay
|
[PMID: 21330015] |
| SNU-638 | IC50 |
2.2 μM
Compound: Ellipticine
|
Cytotoxicity against human SNU638 cells by MTT assay
Cytotoxicity against human SNU638 cells by MTT assay
|
[PMID: 21353568] |
| SNU-638 | IC50 |
2.7 μM
Compound: Ellipticine
|
Antiproliferative activity against human SNU638 cells after 24 to 72 hrs by SRB assay
Antiproliferative activity against human SNU638 cells after 24 to 72 hrs by SRB assay
|
[PMID: 27064730] |
| SW480 | IC50 |
3.17 μM
Compound: Ellipticine
|
Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
Cytotoxic activity against human SW480 cells assessed as inhibition of cell growth incubated for 48 hrs by SRB method
|
[PMID: 26077495] |
| SW480 | IC50 |
0.38 μg/mL
Compound: Ellipticine
|
Antiproliferative activity against human SW480 cells
Antiproliferative activity against human SW480 cells
|
[PMID: 26459207] |
| SW480 | IC50 |
0.75 μM
Compound: Ellipticine
|
Cytotoxicity against human SW480 cells after 3 days by MTT assay
Cytotoxicity against human SW480 cells after 3 days by MTT assay
|
[PMID: 27517802] |
| U-251 | GI50 |
0.93 μM
Compound: 1 (Ellipticine)
|
Cytotoxic effect on growth inhibition of CNS cancer U251 cells
Cytotoxic effect on growth inhibition of CNS cancer U251 cells
|
[PMID: 8765520] |
| Vero | IC50 |
0.4 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 11277765] |
| Vero | IC50 |
1 μg/mL
Compound: elipticine
|
Cytotoxicity against african green monkey kidney fibroblast (vero cell)
Cytotoxicity against african green monkey kidney fibroblast (vero cell)
|
[PMID: 12773043] |
| Vero | IC50 |
0.2 μg/mL
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 12828479] |
| Vero | IC50 |
0.2 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 15043440] |
| Vero | IC50 |
0.8 μM
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 16038559] |
| Vero | IC50 |
0.6 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 16309322] |
| Vero | IC50 |
2.44 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 16499340] |
| Vero | IC50 |
2.03 μM
Compound: ellipticine
|
Cytotoxicity against African green monkey Vero cells after 72 hrs
Cytotoxicity against African green monkey Vero cells after 72 hrs
|
[PMID: 17892262] |
| Vero | IC50 |
1.94 μM
Compound: ellipticine
|
Cytotoxicity against African green monkey Vero cells by colorimetric method
Cytotoxicity against African green monkey Vero cells by colorimetric method
|
[PMID: 18363379] |
| Vero | IC50 |
2.1 μM
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by colorimetric method
Cytotoxicity against african green monkey Vero cells by colorimetric method
|
[PMID: 18380478] |
| Vero | IC50 |
1.69 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 19265430] |
| Vero | IC50 |
0.4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay
Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay
|
[PMID: 19368377] |
| Vero | IC50 |
1.16 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 19456117] |
| Vero | IC50 |
5.5 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells after 8 days by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells after 8 days by green fluorescent protein microplate assay
|
[PMID: 19739600] |
| Vero | IC50 |
0.48 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 19778068] |
| Vero | IC50 |
0.7 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay
Cytotoxicity against african green monkey Vero cells by sulforhodamine B assay
|
[PMID: 19943622] |
| Vero | IC50 |
1.75 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by SRB assay
Cytotoxicity against African green monkey Vero cells by SRB assay
|
[PMID: 20038128] |
| Vero | IC50 |
1.18 μg/mL
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein assay
|
[PMID: 20329738] |
| Vero | IC50 |
2.29 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein based assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein based assay
|
[PMID: 20362442] |
| Vero | IC50 |
3.8 μM
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 20364867] |
| Vero | IC50 |
4.47 μM
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells
Cytotoxicity against african green monkey Vero cells
|
[PMID: 20815366] |
| Vero | IC50 |
3.82 μM
Compound: ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 21302964] |
| Vero | IC50 |
12 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 21473608] |
| Vero | IC50 |
3.82 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells expressing green fluorescent protein after 4 days by fluorescence analysis
Cytotoxicity against african green monkey Vero cells expressing green fluorescent protein after 4 days by fluorescence analysis
|
[PMID: 21641693] |
| Vero | IC50 |
9.8 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against african green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 21995505] |
| Vero | IC50 |
1.19 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by SRB assay
Cytotoxicity against african green monkey Vero cells by SRB assay
|
[PMID: 23806014] |
| Vero | IC50 |
1.94 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells after 4 days by GFP detection method
Cytotoxicity against african green monkey Vero cells after 4 days by GFP detection method
|
[PMID: 24836071] |
| Vero | IC50 |
6.48 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells by green fluorescent protein detection method
|
[PMID: 24857542] |
| Vero | IC50 |
1.94 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 4 days by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability after 4 days by green fluorescent protein detection method
|
[PMID: 25078311] |
| Vero | IC50 |
15.51 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay
Cytotoxicity against african green monkey Vero cells assessed as growth inhibition after 24 hrs by sulforhodamine B assay
|
[PMID: 25337628] |
| Vero | IC50 |
3.8 μM
Compound: ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell growth incubated at 37 degC for 4 days by fluorescence based assay
|
[PMID: 25734623] |
| Vero | IC50 |
1.94 μM
Compound: Ellipticine
|
Cytotoxicity against african green monkey Vero cells after 4 days by green fluorescent protein detection method
Cytotoxicity against african green monkey Vero cells after 4 days by green fluorescent protein detection method
|
[PMID: 25934226] |
| Vero | IC50 |
4.05 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells after 4 days by GFP detection method
Cytotoxicity against African green monkey Vero cells after 4 days by GFP detection method
|
[PMID: 26397393] |
| Vero | IC50 |
3.3 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 26716912] |
| Vero | IC50 |
0.4 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay
Cytotoxicity against African green monkey Vero cells by sulforhodamine B assay
|
[PMID: 26928423] |
| Vero | IC50 |
1 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells
Cytotoxicity against African green monkey Vero cells
|
[PMID: 27228159] |
| Vero | IC50 |
4.26 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
|
[PMID: 27311894] |
| Vero | IC50 |
3.3 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by GFP based microplate assay
Cytotoxicity against African green monkey Vero cells by GFP based microplate assay
|
[PMID: 28504879] |
| Vero | IC50 |
1.94 μM
Compound: Ellipticine
|
Cytotoxicity against GFP-expressing African green monkey Vero cells after 4 days by fluorescence assay
Cytotoxicity against GFP-expressing African green monkey Vero cells after 4 days by fluorescence assay
|
[PMID: 29137864] |
| Vero | IC50 |
4.06 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by GFP-based assay
Cytotoxicity against African green monkey Vero cells by GFP-based assay
|
[PMID: 30078607] |
| Vero | IC50 |
4.1 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 30860372] |
| Vero | IC50 |
3.1 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by GFP based microplate assay
Cytotoxicity against African green monkey Vero cells by GFP based microplate assay
|
[PMID: 30983350] |
| Vero | IC50 |
4.06 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
[PMID: 31620225] |
| Vero | IC50 |
7.47 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay
|
[PMID: 32193929] |
| Vero | IC50 |
0.87 μg/mL
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells by green fluorescent protein-based assay
|
[PMID: 32639735] |
| Vero | IC50 |
7.9 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
Cytotoxicity against African green monkey Vero cells by green fluorescent protein microplate assay
|
[PMID: 33852304] |
| Vero | IC50 |
4 μg/mL
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells by colorimetric assay
Cytotoxicity against African green monkey Vero cells by colorimetric assay
|
[PMID: 33861594] |
| Vero | IC50 |
2.4 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability measured after 72 hrs by SRB assay
|
[PMID: 34624822] |
| Vero | IC50 |
4.5 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by resazurin microplate assay
|
[PMID: 34748348] |
| Vero | IC50 |
2.9 μM
Compound: Ellipticine
|
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition by GFP fluorescence based assay
Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition by GFP fluorescence based assay
|
[PMID: 37816683] |
| ZR-75-1 | ED50 |
0.9 μg/mL
Compound: Ellipticine
|
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay
|
[PMID: 7528785] |
Ellipticine (NSC 71795) is a potent antineoplastic agent exhibiting the multimodal mechanism of its action. The mechanisms of Ellipticine (NSC 71795) antitumor, mutagenic and cytotoxic activities are suggested to be intercalation into DNA and inhibition of DNA topoisomerase II activity. Another mode of Ellipticine (NSC 71795) action is the formation of covalent DNA adducts mediated by its oxidation with cytochromes P450 (CYP) and peroxidases[1]. Ellipticine (NSC 71795) can also act as an inhibitor or inducer of biotransformation enzymes, thereby modulating its own metabolism leading to its genotoxic and pharmacological effects. Treatment of cells with Ellipticine (NSC 71795) results in inhibition of cell growth and proliferation. This effect is associated with formation of two covalent Ellipticine (NSC 71795)-derived DNA adducts[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 519-23-3
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Appearance Solid
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Molecular Weight 246.31
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Formula C17H14N2
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Color Light yellow to yellow
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SMILES
CC1=C(C=NC=C2)C2=C(C)C(N3)=C1C4=C3C=CC=C4
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Synonyms
NSC 71795
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (4)
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Journal Impact Factor
-
Most Recent
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J Adv Res
Postantibiotic leukocyte enhancement-mediated reduction of intracellular bacteria by macrophages. [Abstract]2024 Apr:58:117-128. PMID: 37290606 -
Blood Cancer Discov
2026 Jul 1;7(4):624-641. PMID: 42149820 -
J Cell Biol
2023 Jan 2;222(1):e202202110. PMID: 36282216 -
Front Cell Dev Biol
Time-Course Transcriptome Analysis for Drug Repositioning in Fusobacterium nucleatum-Infected Human Gingival Fibroblasts. [Abstract]2019 Sep 20;7:204. PMID: 31608279
Solvent & Solubility
DMSO : 5.8 mg/mL (23.55 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.16 mg/mL (8.77 mM); Clear solution
This protocol yields a clear solution of ≥ 2.16 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (21.6 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Protocol
The cytotoxicity of ellipticine is determined by MTT test. Ellipticine (NSC 71795) is dissolved in DMSO (1 mM) and diluted in culture medium to final concentrations of 0, 0.1, 1, 5 or 10 μM. Cells in exponential growth are seeded at 1×104 per well in a 96-well microplate. After incubation the MTT solution is added, the microplates are incubated for 4 hours and cells lysed in 50% N,N-dimethylformamide containing 20% of sodium dodecyl sulfate (SDS), pH 4.5. The absorbance at 570 nm is measured. The mean absorbance of medium controls is subtracted as a background. The viability of control cells is taken as 100% and the values of treated cells are calculated as a percentage of control. The IC50 values are calculated using linear regression of the dose-log response curves[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (281 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23. [Content Brief]
[2]. Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105. [Content Brief]
[3]. Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0599 mL | 20.2996 mL | 40.5992 mL | 101.4981 mL |
| 5 mM | 0.8120 mL | 4.0599 mL | 8.1198 mL | 20.2996 mL | |
| 10 mM | 0.4060 mL | 2.0300 mL | 4.0599 mL | 10.1498 mL | |
| 15 mM | 0.2707 mL | 1.3533 mL | 2.7066 mL | 6.7665 mL | |
| 20 mM | 0.2030 mL | 1.0150 mL | 2.0300 mL | 5.0749 mL |