α4β7 Integrin-IN-1
α4β7 Integrin-IN-1 (Example 356) is a potent inhibitor of α4β7 integrin (integrin). Its ability to block the interaction between α4β7 integrin and MadCAM-1 (EC50) is 0.05 nM. α4β7 Integrin-IN-1 can be used for the study of inflammatory bowel disease and Crohn's disease.
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- CAS No.: 2417307-52-7
- Formule: C33H28F4N6O6
- Masse moléculaire:680.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Pureté et documentation
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
α4β7 |
In Vitro
α4β7 Integrin binds to MAdCAM-1 on intestinal endothelium, mediating the homing of lymphocytes to the intestinal mucosa, and is a core driving pathway for ulcerative colitis and Crohn's disease[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417307-52-7
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Masse moléculaire 680.61
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Formule C33H28F4N6O6
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SMILES
CN(C(N1C2=CC=C(C3=C2N=CC=C3)C[C@H](NC(C(C(F)=C4)=C(C)C=C4N5CCOC[C@@H]5C(F)(F)F)=O)C(O)=O)=O)C6=CN=CC=C6C1=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α4β7 Integrin-IN-1 Related Classifications
HY-177961 Related Classifications
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