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LyP-1 

Cat. No.: HY-P2526
Handling Instructions

LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

LyP-1 Chemical Structure

LyP-1 Chemical Structure

CAS No. : 454487-07-1

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Description

LyP-1 is a cyclic 9‐amino‐acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells[1].

In Vivo

LyP-1 (8 weeks) shows a remarkable reduction in plaque formation and plaque occupation rates in the LyP-1-treated group. In addition, a higher apoptotic rate in macrophages released from hypoxic plaques is observed after the treatment of LyP-1when compared to control peptide[1].
The LyP-1 peptide is labeled with a near-infrared fluorophore (Cy5.5) for optical imaging.
At days 3, 7, 14 and 21 after inoculation with 4T1 cells, tumor-bearing BALB/C mice is injected Cy5.5-LyP-1 (0.8 nmol) through the middle phalanges of the upper extremities of the tumor-bearing mice. The fluorescence intensities were 0.024, 0.038, 0.048 and 0.106 × 106 photon/cm2/sec respectively at days 3, 7, 14 and 21 after tumor cell inoculation, which are 1.02, 1.63, 2.04, and 4.52-fold higher than in the contralateral LNs. Cy5.5-LyP-1 staining in LNs co-localized with LYVE-1, suggesting lymphatics-specific binding of LyP-1 peptide[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

992.14

Formula

C₃₆H₆₅N₁₇O₁₂S₂

CAS No.

454487-07-1

Sequence Shortening

CGNKRTRGC (Disulfide bridge: Cys1-Cys9)

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

LyP-1LyP1LyP 1Otherstumor homingp32 receptorInhibitorinhibitorinhibit

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