DSG-PEG2000-DHLASLWWGTEL

DSG-PEG2000-DHLASLWWGTEL is composed of three covalently linked components: 1. DSG (distearoylglycerol) : Lipid anchoring group-a diacylglycerol with two saturated C18 chains; provides strong membrane rigidity and sustained nanoparticle stability, suitable for applications requiring prolonged circulation time. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. DHLASLWWGTEL peptide: Targeting/functional ligand-the DHLASLWWGTEL peptide (also known as TJ12P1) specifically binds to phosphatidylinositol proteoglycan 3 (GPC3), which is highly expressed on the surface of hepatocellular carcinoma, achieving precise targeting of GPC3-positive cells.

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