1. Cytoskeleton
  2. Integrin
  3. Gly-Arg-Gly-Asp-Ser

Gly-Arg-Gly-Asp-Ser 

Cat. No.: HY-P0295 Purity: 98.12%
Handling Instructions

Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Gly-Arg-Gly-Asp-Ser Chemical Structure

Gly-Arg-Gly-Asp-Ser Chemical Structure

CAS No. : 96426-21-0

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2 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 108 In-stock
Estimated Time of Arrival: December 31
10 mg USD 168 In-stock
Estimated Time of Arrival: December 31
25 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[1]

IC50 & Target

IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)[2]

In Vitro

Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM[1]. Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation[2].

Molecular Weight

490.47

Formula

C₁₇H₃₀N₈O₉

CAS No.

96426-21-0

Sequence

Gly-Arg-Gly-Asp-Ser

Sequence Shortening

GRGDS

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (203.89 mM; Need ultrasonic)

H2O : 33.33 mg/mL (67.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0389 mL 10.1943 mL 20.3886 mL
5 mM 0.4078 mL 2.0389 mL 4.0777 mL
10 mM 0.2039 mL 1.0194 mL 2.0389 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Gly-Arg-Gly-Asp-Ser
Cat. No.:
HY-P0295
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