DSPE-PEG2000-cRGD
Based on 1 Customer Validation
DSPE-PEG2000-cRGD is a PEG compound which composed of DSPE and an αvβ3 targeting peptide (cRGD). cRGD peptide can specifically bind to αvβ3 on the surface of many cancer cells and neovascular cells. DSPE-PEG2000-cRGD can be used for drug delivery.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 95.0%
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
αvβ3 |
In Vitro
DSPE-PEG2000-cRGD can be used to construct pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD (PCNR). pp-siRNA/CLD/DNCA/DSPE-PEG2000-cRGD nanoparticles can specifically target tumor cells that highly express integrin αvβ3[2].
Incorporating DSPE-PEG2000-cRGD into liposomes can form spatially stable and integrin-targeting liposomes[3].
DSPE-PEG2000-cRGD can be used to construct C-siRNA/MTSLR-U and C-siRNA/MTSLR, which have anti-hepatocellular carcinoma activity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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Appearance Solid
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Color White to off-white
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SMILES
[Cyclo(RGD-{d-Phe}-K)]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureza y Documentación
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Ficha de datos (278 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Gajbhiye KR, et al. cRGD functionalised nanocarriers for targeted delivery of bioactives. J Drug Target. 2019 Feb;27(2):111-124. [Content Brief]
[2]. Zhang Y, et al. Construction of a Targeting Nanoparticle of 3',3″-Bis-Peptide-siRNA Conjugate/Mixed Lipid with Postinserted DSPE-PEG2000-cRGD. Mol Pharm. 2019 Dec 2;16(12):4920-4928. [Content Brief]
[3]. Khabazian E, et al. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells. J Drug Target. 2022 Jun;30(5):522-533. [Content Brief]
[4]. Nai J, et al. Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells. Mol Ther Nucleic Acids. 2021 Dec 11;27:349-362. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DSPE-PEG2000-cRGD Related Classifications
HY-172464 Related Classifications
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