DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) 

DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) is a PEG compound which composed of DSPE and a nine residue peptide (LyP-1) (HY-P2526). LyP-1 is a cyclic 9-amino-acids tumor homing peptide and selectively bind to p32 receptors overexpressed in various tumor-associated cells^[1].

DSPE (distearate phosphatidylethanolamine): Acts as a hydrophobic anchor. Its two long hydrophobic chains are stably embedded in the lipid bilayer of the nanocarrier.
PEG1000 (polyethylene glycol, molecular weight 1000 Da): Acts as a hydrophilic linker and cryptic layer. Provides long-cycle functionality and exposes active peptides on the nanoparticle surface.
CGNKRTRGC (Lyp-1): A cyclic nonapeptide formed by disulfide bonds between two cysteine ​​residues at the N- and C-termini. CGNKRTRGC specifically recognizes and binds to neurociliaryin-1, which is highly expressed on the surface of tumor lymphatic endothelial cells and certain tumor cells.
DSPE-PEG1000-Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10) enables active targeting and penetration of tumor tissue.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1000 (Average)

Solid

White to off-white

[Mal-Cys-CGNKRTRGC (Disulfide bridge: Cys2-Cys10)]C(CCOCCOC(NCCOP(OC[C@](COC(CCCCCCCCCCCCCCCCC)=O)([H])OC(CCCCCCCCCCCCCCCCC)=O)(O)=O)=O)=O.[n]

Room temperature in continental US; may vary elsewhere.

• [1]. Uchida M, et al. Protein cage nanoparticles bearing the LyP-1 peptide for enhanced imaging of macrophage-rich vascular lesions. ACS Nano. 2011 Apr 26;5(4):2493-502.  [Content Brief]