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ML239 

Cat. No.: HY-19971 Purity: 99.23%
Handling Instructions

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

For research use only. We do not sell to patients.

ML239 Chemical Structure

ML239 Chemical Structure

CAS No. : 1378872-36-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
25 mg USD 270 In-stock
Estimated Time of Arrival: December 31
50 mg USD 430 In-stock
Estimated Time of Arrival: December 31
100 mg USD 680 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.

In Vitro

ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with ∼24-fold selectivity against the control cell line[1]. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs)[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 300 mg/mL (865.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8852 mL 14.4259 mL 28.8517 mL
5 mM 0.5770 mL 2.8852 mL 5.7703 mL
10 mM 0.2885 mL 1.4426 mL 2.8852 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[2]

Cancer cell lines (CCLs) are plated at a density of 500 cells/well in white opaque tissue-culture-treated Aurora 1536-well MaKO plates in the provider-recommended growth media using a highly automated platform. Compounds (ML239) are added by acoustic transfer using a Labcyte Echo 555. 24 hours after plating. The effects of small molecules (ML239) are measured over a 16-point concentration range (two-fold dilution) in duplicate. DMSO is used at a constant concentration of 0.33%, including vehicle-only control wells. As a surrogate for viability, cellular ATP levels are assessed 72 hours after compound transfer by addition of CellTiterGlo followed by luminescence measurement using a ViewLux Microplate Imager. Duplicates are averaged and luminescence values normalized to vehicle (DMSO) treatment and background (media-only) wells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

346.60

Formula

C₁₃H₁₀Cl₃N₃O₂

CAS No.

1378872-36-6

SMILES

O=C(N/N=C/C1=CC=CN1)COC2=C(Cl)C=C(Cl)C=C2Cl

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ML239
Cat. No.:
HY-19971
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ML239

Cat. No.: HY-19971