2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. ANO1-IN-1

ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells.

For research use only. We do not sell to patients.

ANO1-IN-1 Chemical Structure

ANO1-IN-1 Chemical Structure

CAS No. : 407587-01-3

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10 mg USD 70 In-stock
25 mg USD 145 In-stock
50 mg USD 230 In-stock
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Based on 1 publication(s) in Google Scholar

ANO1-IN-1 Related Antibodies

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Description

ANO1-IN-1 (Compound 9c) is a selective ANO1 channel blocker with an IC50 of 2.56 μM and 15.43 μM against ANO1 and ANO2, respectively. ANO1-IN-1 suppresses strongly proliferation of glioblastoma cells[1].

IC50 & Target

IC50: 2.56 μM (ANO1), 15.43 μM (ANO2)[1]
In Vitro

ANO1-IN-1 (Compound 9c) (10 μM) significantly suppresses migration and invasion of U251 cells[1].
ANO1-IN-1 and TMZ combination brings about remarkable synergistic effects in suppressing proliferation of GBM cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ANO1-IN-1 Related Antibodies
Molecular Weight

336.49

Formula

C18H28N2O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)(C(NC1=C(C2=C(S1)CC(CC2)C(C)(C)C)C(N)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (742.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9719 mL 14.8593 mL 29.7186 mL
5 mM 0.5944 mL 2.9719 mL 5.9437 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9719 mL 14.8593 mL 29.7186 mL 74.2964 mL
5 mM 0.5944 mL 2.9719 mL 5.9437 mL 14.8593 mL
10 mM 0.2972 mL 1.4859 mL 2.9719 mL 7.4296 mL
15 mM 0.1981 mL 0.9906 mL 1.9812 mL 4.9531 mL
20 mM 0.1486 mL 0.7430 mL 1.4859 mL 3.7148 mL
25 mM 0.1189 mL 0.5944 mL 1.1887 mL 2.9719 mL
30 mM 0.0991 mL 0.4953 mL 0.9906 mL 2.4765 mL
40 mM 0.0743 mL 0.3715 mL 0.7430 mL 1.8574 mL
50 mM 0.0594 mL 0.2972 mL 0.5944 mL 1.4859 mL
60 mM 0.0495 mL 0.2477 mL 0.4953 mL 1.2383 mL
80 mM 0.0371 mL 0.1857 mL 0.3715 mL 0.9287 mL
100 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7430 mL
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ANO1-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANO1-IN-1407587-01-3Chloride ChannelCl− ChannelsANO1 chloride ion channelglioblastomaGBMU87MGU251U138Inhibitorinhibitorinhibit

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