1. Membrane Transporter/Ion Channel
  2. Chloride Channel
  3. Eact

Eact 

Cat. No.: HY-103368
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Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity.

For research use only. We do not sell to patients.

Eact Chemical Structure

Eact Chemical Structure

CAS No. : 461000-66-8

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Description

Eact is a selective and potent activator of TMEM16A, directly activates the TRPV1 channels in sensory nociceptors and produces itch, acute nociception and thermal hypersensitivity[1].

In Vitro

Eact elicits both itch-and pain- related behaviours in a TRPV1-dependent manner. Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner with an EC50 of 11.6 ± 2.5 μM. TMEM16A activator Eact activates both native and recombinant TRPV1 channels[1].

Molecular Weight

428.50

Formula

C₂₂H₂₄N₂O₅S

CAS No.

461000-66-8

SMILES

O=C(N(CCOC)C1=NC(C2=CC=CC=C2)=CS1)C3=CC(OC)=C(OC)C(OC)=C3

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Room temperature in continental US; may vary elsewhere.

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Keywords:

EactChloride ChannelCl− ChannelsInhibitorinhibitorinhibit

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