1. Membrane Transporter/Ion Channel
  2. Chloride Channel
  3. T16Ainh-A01

T16Ainh-A01 

Cat. No.: HY-100612 Purity: >99.0%
Handling Instructions

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC).

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T16Ainh-A01 Chemical Structure

T16Ainh-A01 Chemical Structure

CAS No. : 552309-42-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 137 In-stock
Estimated Time of Arrival: December 31
1 mg USD 70 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC50 value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC)[1][2].

IC50 & Target

TMEM16A[1].

In Vitro

T16Ainh-A01 (0.3-30 μM) significantly reduces both inward and outward components of IClCa, and inhibits IClCa in RUICC without significantly affecting L-type Ca2+ current[1].
T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism[2].

Molecular Weight

416.52

Formula

C₁₉H₂₀N₄O₃S₂

CAS No.

552309-42-9

SMILES

O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)CSC3=NC(C)=C(CC)C(N3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : ≥ 10 mg/mL (24.01 mM)

DMSO : ≥ 5 mg/mL (12.00 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4008 mL 12.0042 mL 24.0085 mL
5 mM 0.4802 mL 2.4008 mL 4.8017 mL
10 mM 0.2401 mL 1.2004 mL 2.4008 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >99.0%

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Keywords:

T16Ainh-A01Chloride ChannelCl− ChannelsInhibitorinhibitorinhibit

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T16Ainh-A01
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