1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Chloride Channel
    GABA Receptor
  3. Picrotoxinin

Picrotoxinin 

Cat. No.: HY-B1494 Purity: ≥98.0%
Handling Instructions

Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors.

For research use only. We do not sell to patients.

Picrotoxinin Chemical Structure

Picrotoxinin Chemical Structure

CAS No. : 17617-45-7

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Description

Picrotoxinin, a potent convulsant, is a chloride channel blocker. Picrotoxinin is a noncompetitive GABAA receptor antagonist, which negatively modulates the action of GABA on GABAA receptors[1].

Molecular Weight

292.28

Formula

C₁₅H₁₆O₆

CAS No.

17617-45-7

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (342.14 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4214 mL 17.1069 mL 34.2138 mL
5 mM 0.6843 mL 3.4214 mL 6.8428 mL
10 mM 0.3421 mL 1.7107 mL 3.4214 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

PicrotoxininChloride ChannelGABA ReceptorCl− Channels Gamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorGABAAGABAreceptorvoltageclampchlorideInhibitorinhibitorinhibit

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Product Name:
Picrotoxinin
Cat. No.:
HY-B1494
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