2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE)
  4. DX600 TFA

DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

DX600 TFA Chemical Structure

DX600 TFA Chemical Structure

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5 mg USD 500 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of DX600 TFA:

DX600 TFA Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DX600 TFA

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity[1][2][3].

In Vitro

DX600 (1 μM) TFA inhibits rhACE2 activity by 47%, with a pIC50 of 8.0[4].
DX600 (10 μM) TFA inhibits ACE2 activity by 42% in human MNCs (mononuclear cells)[4].
DX600 (100 nM, 4 h) TFA decreases NR 8383 cell growth and increase in TNF-a and IL-6 content in the supernatant (in the presence of LPS and osthole)[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DX600 TFA Related Antibodies
In Vivo

DX600 (5 μg/kg/day, i.p., daily for 4 weeks) TFA exacerbates diabetes-induced cardiovascular dysfunction in Streptozotocin (HY-13753)-treated diabetes rats[2].
DX600 (0.1 µmol/L/kg, i.v ) TFA increases thrombus weight by 30% in thrombosis model in rats[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: STZ-treated diabetes rats[2]
Dosage: 5 μg/kg/day
Administration: i.p., daily for 4 weeks
Result: Increased cardiac and renal NOX activity.
Molecular Weight

3074.33 (free acid)

Formula

C141H185N35O40S2.xC2HF3O2
Appearance

Solid

Color

White to off-white

Sequence

Ac-Gly-Asp-Tyr-Ser-His-Cys-Ser-Pro-Leu-Arg-Tyr-Tyr-Pro-Trp-Trp-Lys-Cys-Thr-Tyr-Pro-NH2 ( Disulfide bridge: Cys6-Cys17)
Sequence Shortening

Ac-GDYSHCSPLRYYPWWKCTYPDPEGGG-NH2 ( Disulfide bridge: Cys6-Cys17)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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DX600 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DX600DX 600DX-600Angiotensin-converting Enzyme (ACE)renin-angiotensin,systemacutelunginjurydiabetesSTZInhibitorinhibitorinhibit

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DX600 TFA
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HY-P2222A
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