Cat. No.: HY-W009732

Sinapinic acid

(Synonyms: Sinapic acid)

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM, and also inhibits ACE-I activity. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells. Sinapinic acid shows antioxidant and antidiabetic activities. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 530-59-6
Formula: C₁₁H₁₂O₅
Molecular Weight:224.21

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Sinapinic acid Chemical Structure

CAS No.: 530-59-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM^[1], and also inhibits ACE-I activity^[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells^[1]. Sinapinic acid shows antioxidant and antidiabetic activities^[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats^[3].

IC₅₀ & Target^[1]^[2]

HDAC

2.27 mM (IC₅₀)

ACE-I

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	4.6 mM Compound: Sinapic acid	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by FMCA assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by FMCA assay	[PMID: 27162124]
A549	IC₅₀	4.9 mM Compound: Sinapic acid	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 27162124]
A549	IC₅₀	5.7 mM Compound: Sinapic acid	Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by luminescence-based ATP assay Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by luminescence-based ATP assay	[PMID: 27162124]

In Vitro

Sinapinic acid acts as an inhibitor of HDAC, with an IC₅₀ of 2.27 mM^[1]. Sinapinic acid also inhibits ACE-I activity^[2].
? Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC₅₀s of 0.91 ± 0.02 mM and 1.6?±?0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 530-59-6
Appearance Solid
Molecular Weight 224.21
Formula C₁₁H₁₂O₅
Color Off-white to light yellow
SMILES

COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1
Synonyms

Sinapic acid
Structure Classification
- Phenylpropanoids
- Simple Phenylpropanols
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (5)

All Cell Proliferation/Viability AssayWBCell Migration/Invasion AssayCell Imaging/StainingIn Vivo Efficacy Study

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Journal Impact Factor

Food Res Int

Optimal Brassicaceae family microgreens from a phytochemical and sensory perspective. [Abstract]

2024 Oct:193:114812. PMID: 39160037
Am J Chin Med

Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway. [Abstract]

2022;50(8):2185-2197. PMID: 36222121
Food Biosci

2025 Apr.
Drug Dev Res

Sinapic acid inhibits pancreatic cancer proliferation, migration, and invasion via downregulation of the AKT/Gsk-3β signal pathway. [Abstract]

2022 May;83(3):721-734. PMID: 34859906

Sinapinic acid purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 May;83(3):721-734. [Abstract]

Different concentrations of Sinapinic acid (SA) (0, 0.625, 1.25, 2.5, 5, 10, and 20 mM) were used to treat PANC-1 and SW1990 cells for 24 and 48 h.

Sinapinic acid purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 May;83(3):721-734. [Abstract]

The expression of Cyclin E1, CDK2, Cyclin D1, and CDK4 were downregulated by Sinapinic acid (SA) (2.5, 5, 10 mM) in a dose and time dependent manner.

Sinapinic acid purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 May;83(3):721-734. [Abstract]

Cell migration and invasion abilities were significantly suppressed treated with Sinapinic acid (SA) (2.5, 5, 10 mM) in a dose dependent manner.

Sinapinic acid purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 May;83(3):721-734. [Abstract]

Sinapinic acid (SA) (2.5, 5, 10 mM) inhibits colony formation of PC cells in a dose-dependent manner.

Sinapinic acid purchased from MedChemExpress. Usage Cited in: Drug Dev Res. 2022 May;83(3):721-734. [Abstract]

Sinapinic acid (SA) administration (20 mg/kg) tumors grew more slowly, and significant differences of tumor size between two groups were observed.
Research Square Preprint

2022 Feb.

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (223.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 25 mg/mL (111.50 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.4601 mL

22.3003 mL

44.6006 mL

5 mM

0.8920 mL

4.4601 mL

8.9201 mL

10 mM

0.4460 mL

2.2300 mL

4.4601 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline