1. Cell Cycle/DNA Damage
    Epigenetics
    Metabolic Enzyme/Protease
    NF-κB
    Immunology/Inflammation
    Apoptosis
  2. HDAC
    Angiotensin-converting Enzyme (ACE)
    Reactive Oxygen Species
    Apoptosis
  3. Sinapinic acid

Sinapinic acid (Synonyms: Sinapic acid)

Cat. No.: HY-W009732 Purity: 99.61%
Handling Instructions

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM, and also inhibits ACE-I activity. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells. Sinapinic acid shows antioxidant and antidiabetic activities. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats.

For research use only. We do not sell to patients.

Sinapinic acid Chemical Structure

Sinapinic acid Chemical Structure

CAS No. : 530-59-6

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10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Sinapinic acid (Sinapic acid) is a phenolic compound isolated from Hydnophytum formicarum Jack. Rhizome, acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1], and also inhibits ACE-I activity[2]. Sinapinic acid posssess potent anti-tumor activity, induces apoptosis of tumor cells[1]. Sinapinic acid shows antioxidant and antidiabetic activities[2]. Sinapinic acid reduces total cholesterol, triglyceride, and HOMA-IR index, and also normalizes some serum parameters of antioxidative abilities and oxidative damage in ovariectomized rats[3].

IC50 & Target[1][2]

HDAC

2.27 mM (IC50)

ACE-I

 

In Vitro

Sinapinic acid acts as an inhibitor of HDAC, with an IC50 of 2.27 mM[1]. Sinapinic acid also inhibits ACE-I activity[2].
Sinapinic acid inhibits HDAC activity in HeLa cells, suppresses the growth of HeLa and HT29 cells with IC50s of 0.91 ± 0.02 mM and 1.6 ± 0.02 mM at 72 h, respectively, induces apoptosis of these cancer cells[1].

In Vivo

Sinapinic acid (5 or 25 mg/kg, p.o. daily for 4 weeks) increases the serum estradiol concentration; decreases insulin resistance and the triglyceride and total cholesterol concentrations; and favorably affects the parameters of antioxidant abilities (reduces glutathione, superoxide dismutase) and oxidative damage in rats[3].

Molecular Weight

224.21

Formula

C₁₁H₁₂O₅

CAS No.

530-59-6

SMILES

COC1=C(O)C(OC)=CC(/C=C/C(O)=O)=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: 99.61%

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Sinapinic acid
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HY-W009732
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