1. Cell Cycle/DNA Damage
  2. CDK
  3. BMS-265246

BMS-265246 

Cat. No.: HY-15275 Purity: 99.28%
Handling Instructions

BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively.

For research use only. We do not sell to patients.

BMS-265246 Chemical Structure

BMS-265246 Chemical Structure

CAS No. : 582315-72-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 251 In-stock
Estimated Time of Arrival: December 31
5 mg USD 228 In-stock
Estimated Time of Arrival: December 31
10 mg USD 365 In-stock
Estimated Time of Arrival: December 31
50 mg USD 970 In-stock
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100 mg USD 1654 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BMS-265246 is a potent and selective CDK1/2 inhibitor for CDK1/cyclin B and CDK2/cyclin E with IC50 of 6 nM and 9 nM, respectively. IC50 Value: 6 nM(for CDK1/cyclin B); 9 nM(for CDK2/cyclin E) Target: CDK1/2 in vitro: BMS-265246 inhibits the activity of Cdk4/cycD (IC50 = 0.23 μM) and prevents A2780 Cytox with IC50 of 0.76 μM. BMS-265246 when bound to Cdk2, shows the inhibitor resides within the ATP purine binding site and forms important H-bonds with Leu83 on the protein backbone. BMS-265246 represents the most potent Cdk/Cdk2 selective analogue from this chemotype. A recent study shows that BMS-265246 inhibits cell proliferation with EC50 ranging from 0.293 μM-0.492 μM in HCT-116 cells. After treatment of BMS-265246, the dominant cell populations are G2-arrested cells having 4N DNA content, large round nuclei, and low DNA intensity. in vivo:

IC50 & Target[1]

CDK1/cycB

6 nM (IC50)

CDK2/Cyc E

9 nM (IC50)

CDK4/cycD

230 nM (IC50)

Molecular Weight

345.34

Formula

C₁₈H₁₇F₂N₃O₂

CAS No.

582315-72-8

SMILES

CC1=CC(F)=C(C(C2=CN=C(NN=C3)C3=C2OCCCC)=O)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (36.20 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8957 mL 14.4785 mL 28.9570 mL
5 mM 0.5791 mL 2.8957 mL 5.7914 mL
10 mM 0.2896 mL 1.4478 mL 2.8957 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (3.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.28%

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Keywords:

BMS-265246BMS265246BMS 265246CDKCyclin dependent kinaseInhibitorinhibitorinhibit

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Product name:
BMS-265246
Cat. No.:
HY-15275
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