1. Cell Cycle/DNA Damage
    Metabolic Enzyme/Protease
  2. CDK
    Angiotensin-converting Enzyme (ACE)
  3. BMS-265246

BMS-265246 

Cat. No.: HY-15275 Purity: 99.28%
COA Handling Instructions

BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research.

For research use only. We do not sell to patients.

BMS-265246 Chemical Structure

BMS-265246 Chemical Structure

CAS No. : 582315-72-8

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Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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Estimated Time of Arrival: December 31
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5 mg USD 150 In-stock
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10 mg USD 250 In-stock
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50 mg USD 950 In-stock
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100 mg USD 1500 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research[1][2][3].

IC50 & Target[1]

CDK1/cycB

6 nM (IC50)

CDK2/Cyc E

9 nM (IC50)

CDK4/cycD

230 nM (IC50)

In Vitro

BMS-265246 binds at the ATP site and shows cytotoxic activity in ovarian cancer cell (A2780), with an IC50 of 0.76 μM[1].
BMS-265246 (0-10 μM) can dose dependently increase iTreg cell differentiation[2].
BMS-265246 (9 nM, 24 h) inhibits the ability of CHI3L1 to stimulate epithelial cells ACE2 and SPP[3].
BMS-265246 (1 μM, 1 h) prevents E2 induction of EGF3, AREG and CXCL12 in MCF7 cells[4].
BMS-265246 is able to cooperate with Tamoxifen to induce apoptosis in MCF7 cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[3]

Cell Line: Calu-3 cells
Concentration: 9 nM
Incubation Time: 24 hours
Result: Abrogated the ability of CHI3L1 (chitinase 3-like-1) to stimulate epithelial cells ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases).
Molecular Weight

345.34

Formula

C18H17F2N3O2

CAS No.
SMILES

CC1=CC(F)=C(C(C2=CN=C(NN=C3)C3=C2OCCCC)=O)C(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (36.20 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8957 mL 14.4785 mL 28.9570 mL
5 mM 0.5791 mL 2.8957 mL 5.7914 mL
10 mM 0.2896 mL 1.4478 mL 2.8957 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (6.02 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (3.62 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.28%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
BMS-265246
Cat. No.:
HY-15275
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