1. Apoptosis
    Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Apoptosis
    VEGFR
    Akt
  3. (Z)-Guggulsterone

(Z)-Guggulsterone 

Cat. No.: HY-110066 Purity: 98.27%
Handling Instructions

Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

For research use only. We do not sell to patients.

(Z)-Guggulsterone Chemical Structure

(Z)-Guggulsterone Chemical Structure

CAS No. : 39025-23-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 220 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 400 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].

IC50 & Target[1]

VEGF-R2

 

Akt

 

In Vitro

Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: Vascular endothelial growth factor (VEGF)
Concentration: 10, 20 μM
Incubation Time: 24 or 48 hours
Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC.
In Vivo

Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs
Dosage: 1 mg
Administration: Oral; 5 times/week
Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
Molecular Weight

312.45

Formula

C₂₁H₂₈O₂

CAS No.

39025-23-5

SMILES

C[[email protected]@]1(/C2=C/C)[[email protected]](CC2=O)([H])[[email protected]@]3([H])[[email protected]]([[email protected]@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (32.01 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2005 mL 16.0026 mL 32.0051 mL
5 mM 0.6401 mL 3.2005 mL 6.4010 mL
10 mM 0.3201 mL 1.6003 mL 3.2005 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1 mg/mL (3.20 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(Z)-GuggulsteroneApoptosisVEGFRAktVascular endothelial growth factor receptorPKBProtein kinase BInhibitorinhibitorinhibit

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Product Name:
(Z)-Guggulsterone
Cat. No.:
HY-110066
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