1. Apoptosis
    Protein Tyrosine Kinase/RTK
    PI3K/Akt/mTOR
  2. Apoptosis
    VEGFR
    Akt
  3. (Z)-Guggulsterone

(Z)-Guggulsterone 

Cat. No.: HY-110066
Handling Instructions

Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

For research use only. We do not sell to patients.

(Z)-Guggulsterone Chemical Structure

(Z)-Guggulsterone Chemical Structure

CAS No. : 39025-23-5

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Description

Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis[1].

IC50 & Target[1]

VEGF-R2

 

Akt

 

In Vitro

Z-guggulsterone (10, 20 μM; 24 or 48 hours) causes a decrease in the level of VEGF-R2 protein in HUVEC[1].

Western Blot Analysis[1]

Cell Line: Vascular endothelial growth factor (VEGF)
Concentration: 10, 20 μM
Incubation Time: 24 or 48 hours
Result: Caused a decrease in the level of VEGF-R2 protein in HUVEC.
In Vivo

Z-guggulsterone (oral; 1 mg; 5 times/week) results in a statistically significantly decrease in tumor volume and wet tumor weight[1].

Animal Model: Male nude mice (5–6 weeks old) s.c. implanted with DU145 cell-containing Matrigel plugs
Dosage: 1 mg
Administration: Oral; 5 times/week
Result: Resulted in a statistically significantly decrease in tumor volume and wet tumor weight.
Molecular Weight

312.45

Formula

C₂₁H₂₈O₂

CAS No.

39025-23-5

SMILES

C[[email protected]@]1(/C2=C/C)[[email protected]](CC2=O)([H])[[email protected]@]3([H])[[email protected]]([[email protected]@]4(C(CC3)=CC(CC4)=O)C)([H])CC1.[Z]

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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(Z)-Guggulsterone
Cat. No.:
HY-110066
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