1382481-79-9
Chemical Structure
ML289
Synonym(s): VU0463597
- CAS. Nr.: 1382481-79-9
- Formula:C22H23NO3
- Molecular Weight:349.42
IUPAC Name: (R)-(3-(hydroxymethyl)piperidin-1-yl)(4-((4-methoxyphenyl)ethynyl)phenyl)methanone
InChIKey: VSLWUPHHCFQTDB-LJQANCHMSA-N
SMILES: O=C(N1C[C@H](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2
Biological Activity: ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1]. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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ML289 | 98.29% | ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5. ML289 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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