1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. ML289

ML289 (Synonyms: VU0463597)

Cat. No.: HY-19630
Handling Instructions

ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5.

For research use only. We do not sell to patients.

ML289 Chemical Structure

ML289 Chemical Structure

CAS No. : 1382481-79-9

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Description

ML289 (VU0463597) is a potent, selective, and CNS-penetrant mGlu3 (IC50=0.66 μM) negative allosteric modulator. ML289 displays >15-fold selectivity over mGlu2 and is inactive against mGlu5[1].

IC50 & Target[1]

mGluR3

0.66 μM (IC50)

In Vitro

ML289 (VU0463597) is a CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) negative allosteric modulator probe[1].

Molecular Weight

349.42

Formula

C₂₂H₂₃NO₃

CAS No.

1382481-79-9

SMILES

O=C(N1C[[email protected]](CO)CCC1)C2=CC=C(C#CC3=CC=C(OC)C=C3)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ML289VU0463597ML 289ML-289VU 0463597VU-0463597mGluRMetabotropic glutamate receptorsCNS-penetrantnegativeallostericmodulatorprobesubtypesselectiveInhibitorinhibitorinhibit

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