1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. FTIDC

FTIDC 

Cat. No.: HY-100405
Handling Instructions

FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1.

For research use only. We do not sell to patients.

FTIDC Chemical Structure

FTIDC Chemical Structure

CAS No. : 873551-53-2

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Description

FTIDC is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1[1].

IC50 & Target

mGluR1a

5.8 nM (IC50)

mGlu5

6200 nM (IC50)

In Vitro

FTIDC inhibits L-glutamate-induced increases in intracellular Ca2+ concentrations, with IC50 values of 5.8 nM , 5.8 nM , 3.1 nM , 7.7 nM for human mGluR1a, rat mGluR1a, mouse mGluR1a, human mGluR1b in CHO cells, respectively[1].

In Vivo

FTIDC (i.p. or p.o.; 1-30 mg/kg) reduces the duration of face-washing behavior elicited in a dosedependent manner and the inhibitory effect is statistically significant at 10 and 30 mg/kg with i.p. and 30 mg/kg with p.o.[1].

Animal Model: Male CD1 (ICR) mice of 6-weeks-old[1]
Dosage: 1, 3, 10, and 30 mg/kg
Administration: I.p. or p.o.
Result: Reduced the duration of face-washing behavior elicited in a dosedependent manner and was statistically significant at 10 and 30 mg/kg with i.p. and 30 mg/kg with p.o..
Molecular Weight

358.41

Formula

C₁₈H₂₃FN₆O

CAS No.

873551-53-2

SMILES

O=C(N1CC=C(C2=C(C)N(C3=CC=CN=C3F)N=N2)CC1)N(C)C(C)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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