2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. mGluR
  5. mGluR1 Isoform
  6. mGluR1 Modulator

mGluR1 Modulator

mGluR1 Modulators (4):

Cat. No. Product Name Effect Purity
  • HY-15129
    O-Phospho-L-serine
    		Modulator ≥98.0%
    O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.
  • HY-107507
    Ro 01-6128
    		Modulator 99.87%
    Ro 01-6128 is a positive allosteric modulator of mGluR1.
  • HY-100605
    VU0483605
    		Modulator
    VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively.
  • HY-110191
    VU0469650
    		Modulator 98.70%
    VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM.