2829282-00-8
2829282-00-8
Chemical Structure
LY367385 hydrochloride
- CAS No.: 2829282-00-8
- Formula:C10H12ClNO4
- Molecular Weight:245.66
IUPAC Name: (S)-4-(amino(carboxy)methyl)-3-methylbenzoic acid hydrochloride
InChIKey: IGKQWSUZDKTEPR-QRPNPIFTSA-N
SMILES: OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O.[H]Cl
Biological Activity: LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY367385 hydrochloride | 99.44% | LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects. | ||||||||||||||||||||
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LY367385 hydrochloride (Standard) | LY367385 hydrochloride (Standard) is the analytical standard of LY367385 (hydrochloride) (HY-107515A). This product is intended for research and analytical applications. LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects. | |||||||||||||||||||||
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E4CPG | 98.0% | E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation. | ||||||||||||||||||||
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UPF-523 | 99.89% | UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis. | ||||||||||||||||||||
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MCPG sodium | MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) . | |||||||||||||||||||||
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(S)-3,4-DCPG | 98% | (S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8a receptor agonist with an EC50 of 31 nM for human mGlu8a. (S)-3,4-DCPG inhibits Forskolin (HY-15371)-stimulated cAMP formation by activating mGlu8, and modulates presynaptic glutamatergic transmission and synaptic plasticity. (S)-3,4-DCPG can be used in research on inflammatory pain, neuropathic pain, autism spectrum disorder, and glutamatergic synaptic plasticity. | ||||||||||||||||||||
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(R,S)-3,4-Dicarboxyphenylglycine | (R,S)-3,4-Dicarboxyphenylglycine ((RS)-3,4-DCPG) is an AMPA receptor antagonist. (R,S)-3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R,S)-3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases. | |||||||||||||||||||||
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(R)-3,4-DCPG | (R)-3,4-DCPG is an AMPA and NMDA antagonist with a Kd of 77 μM for AMPA. (R)-3,4-DCPG complete antagonizes the NMDA-induced depolarization at a concentration of 500 μM. (R)-3,4-DCPG exhibits a weak antagonistic effect on kainate-induced depolarizations. | |||||||||||||||||||||
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MIL-100(Fe) | 98% | MIL-100(Fe) is a metal-organic framework (MOF). | ||||||||||||||||||||
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3-(4-Acetylphenyl)-2-aminopropanoic acid hydrochloride | 3-(4-Acetylphenyl)-2-aminopropanoic acid hydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | |||||||||||||||||||||
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Methyl-benzene-1,3,5-tricarboxylic acid | Methyl-benzene-1,3,5-tricarboxylic acid (Methyltrimesinsaeure) is a metal-organic framework (MOF). | |||||||||||||||||||||
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5-(Methoxycarbonyl)isophthalic acid | 5-(Methoxycarbonyl)isophthalic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
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References
- [1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.
- [2]. Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38(2):199-207. [Content Brief]
