2829282-00-8
2829282-00-8
Chemical Structure
LY367385 hydrochloride
- CAS No.: 2829282-00-8
- Formula:C10H12ClNO4
- Molecular Weight:245.66
IUPAC Name: (S)-4-(amino(carboxy)methyl)-3-methylbenzoic acid hydrochloride
InChIKey: IGKQWSUZDKTEPR-QRPNPIFTSA-N
SMILES: OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O.[H]Cl
Biological Activity: LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects[1][2].
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LY367385 hydrochloride | 99.44% | LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects. | ||||||||||||||||||||
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LY367385 hydrochloride (Standard) | LY367385 hydrochloride (Standard) is the analytical standard of LY367385 (hydrochloride) (HY-107515A). This product is intended for research and analytical applications. LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.70
HY-107516(S)-3,4-DCPG -
Similarity Score 0.70
HY-107518(R,S)-3,4-Dicarboxyphenylglycine -
Similarity Score 0.70
HY-107519(R)-3,4-DCPG -
Similarity Score 0.66
HY-100372E4CPG -
Similarity Score 0.65
HY-101311UPF-523 -
Similarity Score 0.65
HY-103570MCPG sodium -
Similarity Score 0.64
HY-W112142Methyl-benzene-1,3,5-tricarboxylic acid -
Similarity Score 0.64
HY-W1024533-(4-Acetylphenyl)-2-aminopropanoic acid hydrochloride -
Similarity Score 0.63
HY-W8562135-(Methoxycarbonyl)isophthalic acid -
Explore the MedChemAI to find more analogs
References
- [1]. Clark et al. (+)-2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21): 2777-2780.
- [2]. Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38(2):199-207. [Content Brief]
