MCPG sodium 

MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) ^[1].

MCPG (300 μM, 1, and 3 mM) inhibits the concentration-dependent increase of phosphoinositol (PPI) hydrolysis induced by 1S, 3R-aminocyclopentane-1, 3-dicarboxic acid (ACPD) in hippocampus sections ^[1].
MCPG (20 mM, 200 mM) has a selective blocking effect on long-term potentiation (LTP) (20 mM), and also inhibits tetanus-induced short-term potentiation (STP) (200 mM) ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MCPG (Intracerebroventricular injection) can eliminate the enhancement of field excitatory postsynaptic potential (fEPSP) in the alveolar gyrus induced by tedium stimulation in male Wistar rats ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

231.18

C₁₀H₁₀NNaO₄

1303994-09-3

O=C(O[Na])C(C)(N)C1=CC=C(C(O)=O)C=C1

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• [1]. Riedel G, et al. Inhibition of long-term potentiation in the dentate gyrus of freely moving rats by the metabotropic glutamate receptor antagonist MCPG. J Neurosci. 1995 Jan;15(1 Pt 1):87-98.  [Content Brief]