1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. UPF-523

UPF-523 (Synonyms: AIDA)

Cat. No.: HY-101311
Handling Instructions

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.

For research use only. We do not sell to patients.

UPF-523 Chemical Structure

UPF-523 Chemical Structure

CAS No. : 168560-79-0

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Description

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].

IC50 & Target

mGluR1a

214 μM (IC50)

In Vivo

UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive male hooded Lister rats (320–350 g)[1]
Dosage: 0.18 mg/kg
Administration: I.p.; 0.5 ml per 100 g
Result: Showed no gross motor abnormalities and normal righting reflexes.
Clinical Trial
Molecular Weight

221.21

Formula

C₁₁H₁₁NO₄

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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UPF-523
Cat. No.:
HY-101311
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