1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. UPF-523

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.

For research use only. We do not sell to patients.

UPF-523 Chemical Structure

UPF-523 Chemical Structure

CAS No. : 168560-79-0

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 240 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].

IC50 & Target

mGluR1a

214 μM (IC50)

In Vivo

UPF-523 (0.18 mg/kg; i.p.; 0.5 ml per 100 g) results in a final concentration of 100–150 mM which is below an IC50 of 214 mM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Naive male hooded Lister rats (320–350 g)[1]
Dosage: 0.18 mg/kg
Administration: I.p.; 0.5 ml per 100 g
Result: Showed no gross motor abnormalities and normal righting reflexes.
Clinical Trial
Molecular Weight

221.21

Formula

C11H11NO4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(N)CCC2=C1C=CC(C(O)=O)=C2)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (75.36 mM; ultrasonic and adjust pH to 10 with NaOH)

DMSO : 9.52 mg/mL (43.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5206 mL 22.6030 mL 45.2059 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 4.5206 mL 22.6030 mL 45.2059 mL 113.0148 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL 22.6030 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL 11.3015 mL
15 mM 0.3014 mL 1.5069 mL 3.0137 mL 7.5343 mL
20 mM 0.2260 mL 1.1301 mL 2.2603 mL 5.6507 mL
25 mM 0.1808 mL 0.9041 mL 1.8082 mL 4.5206 mL
30 mM 0.1507 mL 0.7534 mL 1.5069 mL 3.7672 mL
40 mM 0.1130 mL 0.5651 mL 1.1301 mL 2.8254 mL
H2O 50 mM 0.0904 mL 0.4521 mL 0.9041 mL 2.2603 mL
60 mM 0.0753 mL 0.3767 mL 0.7534 mL 1.8836 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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UPF-523 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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UPF-523
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HY-101311
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