168560-79-0
Chemical Structure
UPF-523
Synonym(s): AIDA
- CAS No.: 168560-79-0
- Formula:C11H11NO4
- Molecular Weight:221.21
IUPAC Name: 1-amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid
InChIKey: LSTPKMWNRWCNLS-UHFFFAOYSA-N
SMILES: O=C(C1(N)CCC2=C1C=CC(C(O)=O)=C2)O
Biological Activity: UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis[1][2].
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UPF-523 | 99.89% | UPF-523 (AIDA), a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis. | ||||||||||||||||||||
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References
- [1]. Nielsen KS, et al. Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats. Eur J Pharmacol. 1997;326(2-3):105-108. [Content Brief]
- [2]. Zhang LP, et al. The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat. J Pain. 2000;1(2):151-161. [Content Brief]
