2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (RS)-APICA

(RS)-APICA is a selective group II metabotropic glutamate receptor (mGluR II) antagonist. (RS)-APICA shows potential neuroprotective effect.

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(RS)-APICA Chemical Structure

(RS)-APICA Chemical Structure

CAS No. : 170847-18-4

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Based on 1 publication(s) in Google Scholar

(RS)-APICA Related Antibodies

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

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Description

(RS)-APICA is a selective group II metabotropic glutamate receptor (mGluR II) antagonist. (RS)-APICA shows potential neuroprotective effect[1].

IC50 & Target

mGluR2

 

Molecular Weight

257.18

Formula

C10H12NO5P
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(N)CCC2=C1C=CC(P(O)(O)=O)=C2)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

0.1 M NaOH : 6.25 mg/mL (24.30 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8883 mL 19.4416 mL 38.8833 mL
5 mM 0.7777 mL 3.8883 mL 7.7767 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
0.1 M NaOH 1 mM 3.8883 mL 19.4416 mL 38.8833 mL 97.2082 mL
5 mM 0.7777 mL 3.8883 mL 7.7767 mL 19.4416 mL
10 mM 0.3888 mL 1.9442 mL 3.8883 mL 9.7208 mL
15 mM 0.2592 mL 1.2961 mL 2.5922 mL 6.4805 mL
20 mM 0.1944 mL 0.9721 mL 1.9442 mL 4.8604 mL
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(RS)-APICA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(RS)-APICA170847-18-4mGluRMetabotropic glutamate receptorsneuronal protectionInhibitorinhibitorinhibit

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