1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. E4CPG

E4CPG (Synonyms: (RS)-ECPG)

Cat. No.: HY-100372 Purity: ≥98.0%
Handling Instructions

E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.

For research use only. We do not sell to patients.

E4CPG Chemical Structure

E4CPG Chemical Structure

CAS No. : 170846-89-6

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5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 110 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 460 In-stock
Estimated Time of Arrival: December 31
100 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation[1][2].

IC50 & Target[1]

mGluR

 

In Vitro

E4CPG acts at rat cortical mGluR with the KB value of 0.367 mM[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

E4CPG (3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.), and 1-10 nmol/site (i.c.v.)) significantly inhibits the nociception induced by the Glutamate-injection (i.pl.; 30 μmol/paw), and the maximal inhibition values for the antinociceptive action of E4CPG in Glutamate-induced nociception are 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.) [4].
E4CPG (35 nM/3.5 μL, i.c.v.) completely blocks long-term depression (LTD) induced by the group I mGluR agonist Dihydroxyphenylglycine (DHPG, 100 nM/5 μL, i.c.v.) in male Sprague-Dawley rats[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice (25-35 g)[4]
Dosage: 3-30 nmol/site (i.t.), 1-10 μmol/paw (i.pl.) and 1-10 nmol/ site (i.c.v.)
Administration: Single injection
Result: The maximal inhibition values for the antinociceptive action of E4CPG in glutamate-induced nociception were 48% (i.pl.), 49% (i.t.) and 40% (i.c.v.).
Animal Model: Male Sprague-Dawley rats[5]
Dosage: 35 nM/3.5 μL
Administration: Single injection, i.c.v.
Result: Completely blocked LTD induced by the group I mGluR agonist dihydroxyphenylglycine (DHPG).
Molecular Weight

223.23

Formula

C₁₁H₁₃NO₄

CAS No.

170846-89-6

SMILES

NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (44.80 mM; ultrasonic and adjust pH to 12 with NaOH)

H2O : 1 mg/mL (4.48 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4797 mL 22.3984 mL 44.7968 mL
5 mM 0.8959 mL 4.4797 mL 8.9594 mL
10 mM 0.4480 mL 2.2398 mL 4.4797 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

E4CPG(RS)-ECPGmGluRMetabotropic glutamate receptorsmetabotropicmGluRsInhibitorinhibitorinhibit

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E4CPG
Cat. No.:
HY-100372
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