170846-89-6
170846-89-6
Chemical Structure
E4CPG
Synonym(s): (RS)-ECPG
- CAS No.: 170846-89-6
- Formula:C11H13NO4
- Molecular Weight:223.23
IUPAC Name: 4-(1-amino-1-carboxypropyl)benzoic acid
InChIKey: AIEFWRHRHFRLFT-UHFFFAOYSA-N
SMILES: NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1
Biological Activity: E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation[1][2].
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E4CPG | 98.0% | E4CPG ((RS)-ECPG) is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation. | ||||||||||||||||||||
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References
- [1]. N Sekiyama, et al. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptorsubtypes. Br J Pharmacol, 1996 Apr, 117(7):1493-503. [Content Brief]
- [2]. Christian Patenaude, et al. GABAB receptor- and metabotropic glutamate receptor-dependent cooperative long-term potentiation of rat hippocampal GABAA synaptic transmission. J Physiol. 2003 Nov 15;553(Pt 1):155-67. [Content Brief]
