2. PROTAC
  3. Ligands for E3 Ligase
  4. CRBN ligand-883

CRBN ligand-883 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-883 can be linked to a target protein ligand via a linker to form a PROTAC.

For research use only. We do not sell to patients.

CRBN ligand-883

CRBN ligand-883 Chemical Structure

CAS No. : 1502483-16-0

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
25 mg In-stock
50 mg In-stock
100 mg In-stock
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500 mg   Get quote  

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CRBN ligand-883 Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

CRBN ligand-883 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-883 can be linked to a target protein ligand via a linker to form a PROTAC.

IC50 & Target

Cereblon

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CRBN ligand-883 Related Antibodies
Molecular Weight

233.22

Formula

C12H11NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=CC(=C1)C2C(=O)NC(=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (428.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2878 mL 21.4390 mL 42.8780 mL
5 mM 0.8576 mL 4.2878 mL 8.5756 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2878 mL 21.4390 mL 42.8780 mL 107.1949 mL
5 mM 0.8576 mL 4.2878 mL 8.5756 mL 21.4390 mL
10 mM 0.4288 mL 2.1439 mL 4.2878 mL 10.7195 mL
15 mM 0.2859 mL 1.4293 mL 2.8585 mL 7.1463 mL
20 mM 0.2144 mL 1.0719 mL 2.1439 mL 5.3597 mL
25 mM 0.1715 mL 0.8576 mL 1.7151 mL 4.2878 mL
30 mM 0.1429 mL 0.7146 mL 1.4293 mL 3.5732 mL
40 mM 0.1072 mL 0.5360 mL 1.0719 mL 2.6799 mL
50 mM 0.0858 mL 0.4288 mL 0.8576 mL 2.1439 mL
60 mM 0.0715 mL 0.3573 mL 0.7146 mL 1.7866 mL
80 mM 0.0536 mL 0.2680 mL 0.5360 mL 1.3399 mL
100 mM 0.0429 mL 0.2144 mL 0.4288 mL 1.0719 mL
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CRBN ligand-883 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CRBN ligand-8831502483-16-0CRBN ligand883CRBN ligand 883Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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CRBN ligand-883
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