CRBN ligand-883
Based on 1 Customer Validation
CRBN ligand-883 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-883 can be linked to a target protein ligand via a linker to form a PROTAC.
For research use only. We do not sell to patients.
- Purity: 99.71%
- CAS No.: 1502483-16-0
- Formula: C12H11NO4
- Molecular Weight:233.22
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Biological Activity
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Cereblon |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1502483-16-0
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Appearance Solid
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Molecular Weight 233.22
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Formula C12H11NO4
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC(=C1)C2C(=O)NC(=O)CC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (428.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (243 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.2878 mL | 21.4390 mL | 42.8780 mL | 107.1949 mL |
| 5 mM | 0.8576 mL | 4.2878 mL | 8.5756 mL | 21.4390 mL | |
| 10 mM | 0.4288 mL | 2.1439 mL | 4.2878 mL | 10.7195 mL | |
| 15 mM | 0.2859 mL | 1.4293 mL | 2.8585 mL | 7.1463 mL | |
| 20 mM | 0.2144 mL | 1.0719 mL | 2.1439 mL | 5.3597 mL | |
| 25 mM | 0.1715 mL | 0.8576 mL | 1.7151 mL | 4.2878 mL | |
| 30 mM | 0.1429 mL | 0.7146 mL | 1.4293 mL | 3.5732 mL | |
| 40 mM | 0.1072 mL | 0.5360 mL | 1.0719 mL | 2.6799 mL | |
| 50 mM | 0.0858 mL | 0.4288 mL | 0.8576 mL | 2.1439 mL | |
| 60 mM | 0.0715 mL | 0.3573 mL | 0.7146 mL | 1.7866 mL | |
| 80 mM | 0.0536 mL | 0.2680 mL | 0.5360 mL | 1.3399 mL | |
| 100 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 1.0719 mL |
CRBN ligand-883 Related Classifications
HY-W886312 Related Classifications
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