2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. Ro 67-7476

Ro 67-7476 

Cat. No.: HY-100403 Purity: 99.57%
COA Handling Instructions

Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM).

For research use only. We do not sell to patients.

Ro 67-7476 Chemical Structure

Ro 67-7476 Chemical Structure

CAS No. : 298690-60-5

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Based on 4 publication(s) in Google Scholar

Ro 67-7476 Related Antibodies

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Description

Ro 67-7476 is a potent positive allosteric modulator of mGluR1 and potentiates glutamate-induced calcium release in HEK293 cells expressing rat mGluR1a with an EC50 of 60.1 nM[1][2]. Ro 67-7476 is a potent P-ERK1/2 agonist and activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM)[3].

IC50 & Target[1]

mGluR1a

60.1 nM (EC50)

In Vitro

In the Purkinje cells of rat cerebellar slices, Ro 67-7476 increases the amplitude of mGluR1 excitatory postsynaptic potentials (EPSCs) evoked by 2,3-dihydroxy-6-nitro-7-sulfamoylbenzoquionxaline, picrotoxin, or AP5[3].
? Ro 67-7476 activates ERK1/2 phosphorylation in the absence of exogenously added glutamate (EC50=163.3 nM). The EC50?value of? full P-ERK1/2 activation for Ro 67-7476 are nearly identical to the EC50 for calcium mobilization potentiation[3].
Ro 67-7476 increases basal cAMP production approximately by 8%. It potentiated threshold responses to glutamate in the cAMP accumulation assay, with an EC50?value of 17.7 μM[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ro 67-7476 Related Antibodies
Molecular Weight

319.39

Appearance

Solid

Formula

C17H18FNO2S
CAS No.
SMILES

O=S(N1[C@H](C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (125.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1310 mL 15.6548 mL 31.3097 mL
5 mM 0.6262 mL 3.1310 mL 6.2619 mL
10 mM 0.3131 mL 1.5655 mL 3.1310 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.57%

COA (258 KB) LCMS (263 KB)

Handling Instructions (2659 KB)
References
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Ro 67-7476 Related Classifications

Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Ro 67-7476298690-60-5mGluRMetabotropic glutamate receptorstraumatic injurycAMP accumulationexcitatory postsynaptic potentialsmGluR1neuronal cultureInhibitorinhibitorinhibit

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