1. GPCR/G Protein
  2. mGluR

Ro 67-7476 (Synonyms: Ro67-7476; Ro-67-7476)

Cat. No.: HY-100403
Handling Instructions

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.

For research use only. We do not sell to patients.
Ro 67-7476 Chemical Structure

Ro 67-7476 Chemical Structure

CAS No. : 298690-60-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO $121 In-stock
5 mg $110 In-stock
10 mg $160 In-stock
50 mg $660 In-stock
100 mg $1100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. target: mGlu1 EC 50: 60.1 nM (1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM. (3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.

References
M.Wt

319.39

Formula

C₁₇H₁₈FNO₂S

CAS No.

298690-60-5

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 40 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Ro 67-7476
Cat. No.:
HY-100403
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