1. GPCR/G Protein
  2. mGluR

Ro 67-7476 

Cat. No.: HY-100403 Purity: 98.58%
Handling Instructions

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM.

For research use only. We do not sell to patients.

Ro 67-7476 Chemical Structure

Ro 67-7476 Chemical Structure

CAS No. : 298690-60-5

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 145 In-stock
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Estimated Time of Arrival: December 31
10 mg USD 192 In-stock
Estimated Time of Arrival: December 31
50 mg USD 792 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. Displays no activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. target: mGlu1 EC 50: 60.1 nM (1) Ro 67-7476 (10 μM) can directly block the GIRK channel (to 67 ± 2% of control). (2) Ro 67-7476 enhance the glutamate-induced current in all chimeric receptors containing the transmembrane (TM) region of rmGlu1a (R1, R1-R5N, R1-R5C, and R5-R1TM) but not in those containing the TM region of rmGlu5a (R5, R5-R1N, R5-R1C, and R1-R5TM. (3) The application of Ro 67-7476 (3 μM) produced no effect alone but resulted in a marked potentiation of the mGlu1 EPSC amplitude.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 40 mg/mL (125.24 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1310 mL 15.6548 mL 31.3097 mL
5 mM 0.6262 mL 3.1310 mL 6.2619 mL
10 mM 0.3131 mL 1.5655 mL 3.1310 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

319.39

Formula

C₁₇H₁₈FNO₂S

CAS No.

298690-60-5

SMILES

O=S(N1[[email protected]](C2=CC=C(F)C=C2)CCC1)(C3=CC=C(C)C=C3)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Ro 67-7476
Cat. No.:
HY-100403
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Ro 67-7476

Cat. No.: HY-100403