1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. (S)-3,5-DHPG

(S)-3,5-DHPG 

Cat. No.: HY-12598
Handling Instructions

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia.

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(S)-3,5-DHPG Chemical Structure

(S)-3,5-DHPG Chemical Structure

CAS No. : 162870-29-3

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Description

(S)-3,5-DHPG is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively[1]. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia[2].

IC50 & Target[1]

mGluR1a

0.9 μM (Ki)

mGluR5a

3.9 μM (Ki)

In Vitro

(S)-3,5-DHPG specifically displaces high-affinity quisqualate sites, the putative group I mGlu binding sites[1].

In Vivo

(S)-3,5-DHPG (icv; 0.01, 0.1 and 1.0 nmol/5 μL) improves consolidation and retrieval and exhibits anxiolytic activity in dose-dependent manner in male Wistar rats weighing 160-180 g subjected to hypoxia[2].

Molecular Weight

183.16

Formula

C₈H₉NO₄

CAS No.

162870-29-3

SMILES

O=C(O)[[email protected]@H](N)C1=CC(O)=CC(O)=C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(S)-3,5-DHPGmGluRMetabotropic glutamate receptorsgroupImetabotropicglutamatereceptorsanxiolyticactivityhypoxiaInhibitorinhibitorinhibit

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(S)-3,5-DHPG
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HY-12598
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