409345-76-2
409345-76-2
Chemical Structure
R214127
- CAS No.: 409345-76-2
- Formula:C20H17NO2
- Molecular Weight:303.35
IUPAC Name: 1-(3,4-dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-2-phenylethan-1-one
InChIKey: HXUSRWUBSYSWII-UHFFFAOYSA-N
SMILES: O=C(CC1=CC=CC=C1)C2=CC3=CC4=C(OCCC4)N=C3C=C2
Biological Activity: R214127 is a selective mGlu1 receptor antagonist with IC50 values of 6 and 14 nM for rat and human mGlu1a. R214127 acts on a site from the glutamate binding pocket, and competes for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists[1].
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R214127 | R214127 is a selective mGlu1 receptor antagonist with IC50 values of 6 and 14 nM for rat and human mGlu1a. R214127 acts on a site from the glutamate binding pocket, and competes for the same transmembrane segment VII as other noncompetitive mGlu1 antagonists. | |||||||||||||||||||||
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