2. Others Neuronal Signaling GPCR/G Protein Apoptosis Metabolic Enzyme/Protease PI3K/Akt/mTOR JAK/STAT Signaling Stem Cell/Wnt NF-κB
  3. Isotope-Labeled Compounds mGluR Ferroptosis Environmental Pollutants Endogenous Metabolite HIF/HIF Prolyl-Hydroxylase mTOR STAT NF-κB
  4. L-Glutamine-13C5,15N2

L-Glutamine-13C5,15N2  (Synonyms: L-Glutamic acid 5-amide-13C5,15N2)

Cat. No.: HY-N0390S6 Pureza: 98.0%
COA
SDS
Instrucciones de manejo Technical Support

L-Glutamine-13C5,15N2 is the 13C- and 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.

Para uso exclusivo en investigación. No vendemos a pacientes.

L-Glutamine-<sup>13</sup>C<sub>5</sub>,<sup>15</sup>N<sub>2</sub>

L-Glutamine-13C5,15N2 Estructura química

No. CAS : 285978-14-5

Tamaño Precio Stock Cantidad
1 mg En stock
5 mg En stock
10 mg En stock
50 mg   Obtener un presupuesto  
100 mg   Obtener un presupuesto  

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Other Forms of L-Glutamine-13C5,15N2:

L-Glutamine-13C5,15N2 Related Antibodies

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  • Actividad biológica

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Descripciòn

L-Glutamine-13C5,15N2 is the 13C- and 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity[1][2][3][4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Glutamine-13C5,15N2 Related Antibodies
Peso molecular

153.09

Fòrmula

13C5H1015N2O3
No. CAS
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

[15NH2][13C]([13CH2][13CH2][13C@H]([15NH2])[13C](O)=O)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 25 mg/mL (163.30 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.5321 mL 32.6605 mL 65.3211 mL
5 mM 1.3064 mL 6.5321 mL 13.0642 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Pureza y Documentación

Purity: 98.0%

SDS (252 KB)

COA (249 KB) HNMR (262 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 6.5321 mL 32.6605 mL 65.3211 mL 163.3026 mL
5 mM 1.3064 mL 6.5321 mL 13.0642 mL 32.6605 mL
10 mM 0.6532 mL 3.2661 mL 6.5321 mL 16.3303 mL
15 mM 0.4355 mL 2.1774 mL 4.3547 mL 10.8868 mL
20 mM 0.3266 mL 1.6330 mL 3.2661 mL 8.1651 mL
25 mM 0.2613 mL 1.3064 mL 2.6128 mL 6.5321 mL
30 mM 0.2177 mL 1.0887 mL 2.1774 mL 5.4434 mL
40 mM 0.1633 mL 0.8165 mL 1.6330 mL 4.0826 mL
50 mM 0.1306 mL 0.6532 mL 1.3064 mL 3.2661 mL
60 mM 0.1089 mL 0.5443 mL 1.0887 mL 2.7217 mL
80 mM 0.0817 mL 0.4083 mL 0.8165 mL 2.0413 mL
100 mM 0.0653 mL 0.3266 mL 0.6532 mL 1.6330 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Glutamine-13C5,15N2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Glutamine-13C5,15N2285978-14-5L-Glutamic acid 5-amide-13C5,15N2Isotope-Labeled CompoundsmGluRFerroptosisEnvironmental PollutantsEndogenous MetaboliteHIF/HIF Prolyl-HydroxylasemTORSTATNF-κBMetabotropic glutamate receptorsEnvironmental ContaminantsHypoxia-inducible factorsHIFsHIF-PHMammalian target of RapamycinNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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