L-Glutamine-15N
Based on 4 publication(s) in Google Scholar
L-Glutamine-15N is the 15N-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.6%
- CAS No.: 80143-57-3
- 화학식: C5H10N15NO3
- 분자량:147.14
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보관:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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HY-N0390S1
L-Glutamine-13C5 -
HY-N0390S9
L-Glutamine-15N-1 -
HY-15129
O-Phospho-L-serine -
HY-N6782
Oligomycin -
HY-15129R
O-Phospho-L-serine (Standard) -
HY-B0389A
D-Glucose-13C6 -
HY-101364A
CHPG sodium salt -
HY-135849A
Catalase, Bovine Liver -
HY-N0390
L-Glutamine -
HY-114481
Imidazole ketone erastin -
HY-129457
FINO2 -
HY-139087
Erastin2
Publications Citing Use of MedChemExpress (MCE) L-Glutamine-15N
MoreAll Endogenous Metabolite Isoforms
More
Biological Activity
제품 설명
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
신청
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 80143-57-3
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Unlabeled CAS 56-85-9
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Appearance Solid
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분자량 147.14
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화학식 C5H10N15NO3
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Color White to off-white
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SMILES
NC(CC[C@H]([15NH2])C(O)=O)=O
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Synonyms
L-Glutamic acid 5-amide-15N
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cancer Res
The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma. [Abstract]2025 Aug 21. PMID: 40838989 -
EMBO Mol Med
De novo pyrimidine synthesis is a collateral metabolic vulnerability in NF2-deficient mesothelioma. [Abstract]2025 Jul 24. PMID: 40707702 -
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용액&용해도
In Vitro:
H2O : 20.83 mg/mL (141.57 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou T, et al. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int. 2019;2019:8928934. Published 2019 Sep 12. [Content Brief]
[3]. Luo LL, et al. L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. CNS Neurosci Ther. 2019;25(9):1030-1041. [Content Brief]
[4]. Shao H, et al. The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. BMC Pharmacol Toxicol. 2020;21(1):71. Published 2020 Oct 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.7962 mL | 33.9812 mL | 67.9625 mL | 169.9062 mL |
| 5 mM | 1.3592 mL | 6.7962 mL | 13.5925 mL | 33.9812 mL | |
| 10 mM | 0.6796 mL | 3.3981 mL | 6.7962 mL | 16.9906 mL | |
| 15 mM | 0.4531 mL | 2.2654 mL | 4.5308 mL | 11.3271 mL | |
| 20 mM | 0.3398 mL | 1.6991 mL | 3.3981 mL | 8.4953 mL | |
| 25 mM | 0.2718 mL | 1.3592 mL | 2.7185 mL | 6.7962 mL | |
| 30 mM | 0.2265 mL | 1.1327 mL | 2.2654 mL | 5.6635 mL | |
| 40 mM | 0.1699 mL | 0.8495 mL | 1.6991 mL | 4.2477 mL | |
| 50 mM | 0.1359 mL | 0.6796 mL | 1.3592 mL | 3.3981 mL | |
| 60 mM | 0.1133 mL | 0.5664 mL | 1.1327 mL | 2.8318 mL | |
| 80 mM | 0.0850 mL | 0.4248 mL | 0.8495 mL | 2.1238 mL | |
| 100 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6991 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Glutamine-15N Related Classifications
HY-N0390S Related Classifications
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