L-Glutamine-13C5
Based on 12 publication(s) in Google Scholar
L-Glutamine-13C5 is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.93%
- No. CAS: 184161-19-1
- Fòrmula: 13C5H10N2O3
- Peso molecular:151.11
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) L-Glutamine-13C5
More- Cancer Discov. 2026 Apr 7. [Abstract]
- Nat Metab. 2025 Sep;7(9):1871-1888. [Abstract]
- Cancer Res. 2025 Aug 21. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(16):e2415041. [Abstract]
- Sci Adv. 2026 Jun 12;12(24):eaec8873. [Abstract]
- Cell Death Dis. 2026 Jun 25. [Abstract]
- Nat Struct Mol Biol. 2024 Sep;31(9):1413-1425. [Abstract]
- Exp Eye Res. 2026 Feb:263:110767. [Abstract]
- Rapid Commun Mass Spectrom. 2025 Apr 30;39(12):e10031. [Abstract]
- Res Sq. 2026 Jan 12.
- SSRN. 2025 May 7.
- Northwestern University. 2024.
Customer Validation & Images
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
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Actividad biológica
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 184161-19-1
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Unlabeled Cas 56-85-9
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Appearance Solid
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Peso molecular 151.11
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Fòrmula 13C5H10N2O3
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Color White to off-white
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SMILES
N[13C]([13CH2][13CH2][13C@H](N)[13C](O)=O)=O
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Synonyms
L-Glutamic acid 5-amide-13C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (12)
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Journal Impact Factor
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Most Recent
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Cancer Discov
Correcting Mitochondrial Complex I Defect in Tumor-Associated Natural Killer Cells Potentiates Immunotherapy for Glioblastoma. [Abstract]2026 Apr 7. PMID: 41944586 -
Nat Metab
Cellular pan-chain acyl-CoA profiling reveals SLC25A42/SLC25A16 in mitochondrial CoA import and metabolism. [Abstract]2025 Sep;7(9):1871-1888. PMID: 40925986
L-Glutamine-13C5 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep;7(9):1871-1888. [Abstract]
Isotopologue abundance of citrate/isocitrate, α-ketoglutarate, succinate, fumarate, malate, and aspartate in ctrl, A42 KO, A16 KO, and A16/A42 DKO HeLa cells with L-Glutamine-13C5 tracing (2 mM for 2 hrs) with naturally occurring 13C abundance correction.
L-Glutamine-13C5 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2025 Sep;7(9):1871-1888. [Abstract]
Stable isotope tracing of A16/A42 DKO K562 cells using L-Glutamine-13C5 (2 mM for 2 h).
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Cancer Res
The Acetyltransferase ARD1 Induces Glutathione Synthesis to Facilitate Ferroptosis Evasion in Hepatocellular Carcinoma. [Abstract]2025 Aug 21. PMID: 40838989 -
Adv Sci (Weinh)
Metabolomic and Cellular Mechanisms of Drug-Induced Ototoxicity and Nephrotoxicity: Therapeutic Implications of Uric Acid Modulation. [Abstract]2025 Apr;12(16):e2415041. PMID: 40041973 -
Sci Adv
SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes. [Abstract]2026 Jun 12;12(24):eaec8873. PMID: 42284407 -
Cell Death Dis
Targeting mitochondrial α-ketoglutarate sequestration disables dual oncogenic drivers and metabolic adaptability in pancreatic ductal adenocarcinoma. [Abstract]2026 Jun 25. PMID: 42350388 -
Nat Struct Mol Biol
RNAi screens identify HES4 as a regulator of redox balance supporting pyrimidine synthesis and tumor growth. [Abstract]2024 Sep;31(9):1413-1425. PMID: 38769389
L-Glutamine-13C5 purchased from MedChemExpress. Usage Cited in: Nat Struct Mol Biol. 2024 Sep;31(9):1413-1425. [Abstract]
Isotopomer distributions of citrate from L-Glutamine-13C5 (2 mM for 24 h) was analyzed in shCtrl and shHES4 A549 cells reconstituted with or without WT rHES4.
L-Glutamine-13C5 purchased from MedChemExpress. Usage Cited in: Nat Struct Mol Biol. 2024 Sep;31(9):1413-1425. [Abstract]
Schematic of isotopomer distribution of indicated metabolites derived from L-Glutamine-13C5 (2 mM for 24 h) . 13C atoms are depicted in blue.
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Exp Eye Res
Uncovering the metabolic landscape of aqueous humor in posterior subcapsular cataract associated with hyperuricemia. [Abstract]2026 Feb:263:110767. PMID: 41275899 -
Rapid Commun Mass Spectrom
Rapid Determination of Isotopic Purity of Stable Isotope (D, 15N, or 13C)-Labeled Organic Compounds by Electrospray Ionization-High-Resolution Mass Spectrometry. [Abstract]2025 Apr 30;39(12):e10031. PMID: 40133084 -
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Solvente y solubilidad
H2O : 10 mg/mL (66.18 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (110.32 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Zhou T, et al. Glutamine Metabolism Is Essential for Stemness of Bone Marrow Mesenchymal Stem Cells and Bone Homeostasis. Stem Cells Int. 2019;2019:8928934. Published 2019 Sep 12. [Content Brief]
[3]. Luo LL, et al. L-glutamine protects mouse brain from ischemic injury via up-regulating heat shock protein 70. CNS Neurosci Ther. 2019;25(9):1030-1041. [Content Brief]
[4]. Shao H, et al. The protective effect of L-glutamine against acute Cantharidin-induced Cardiotoxicity in the mice. BMC Pharmacol Toxicol. 2020;21(1):71. Published 2020 Oct 1. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 6.6177 mL | 33.0885 mL | 66.1770 mL | 165.4424 mL |
| 5 mM | 1.3235 mL | 6.6177 mL | 13.2354 mL | 33.0885 mL | |
| 10 mM | 0.6618 mL | 3.3088 mL | 6.6177 mL | 16.5442 mL | |
| 15 mM | 0.4412 mL | 2.2059 mL | 4.4118 mL | 11.0295 mL | |
| 20 mM | 0.3309 mL | 1.6544 mL | 3.3088 mL | 8.2721 mL | |
| 25 mM | 0.2647 mL | 1.3235 mL | 2.6471 mL | 6.6177 mL | |
| 30 mM | 0.2206 mL | 1.1029 mL | 2.2059 mL | 5.5147 mL | |
| 40 mM | 0.1654 mL | 0.8272 mL | 1.6544 mL | 4.1361 mL | |
| 50 mM | 0.1324 mL | 0.6618 mL | 1.3235 mL | 3.3088 mL | |
| 60 mM | 0.1103 mL | 0.5515 mL | 1.1029 mL | 2.7574 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Glutamine-13C5 Related Classifications
HY-N0390S1 Related Classifications
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