1. GPCR/G Protein
  2. mGluR

MTEP hydrochloride (Synonyms: 3-((2-Methyl-1,3-thiazol-4-yl)ethyn-yl)pyridine hydrochloride; MTEP)

Cat. No.: HY-13206 Purity: 99.89%
Data Sheet SDS Handling Instructions

MTEP Hcl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively.

For research use only. We do not sell to patients.
MTEP hydrochloride Chemical Structure

MTEP hydrochloride Chemical Structure

CAS No. : 1186195-60-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $94 In-stock
10 mg $85 In-stock
50 mg $382 In-stock
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Description

MTEP Hcl is a potent, selective and non-competitive mGlu5 antagonist with IC50 and Ki of 5 nM and 16 nM, respectively. IC50 Value: 5 nM [1] Target: mGluR5 MTEP occupied mGlu5 receptors in a dose-dependent manner with essentially full receptor occupancy at the highest dose tested (10 mg/kg, i.p.). At doses appropriate for mGlu5 receptor-mediated effects, MTEP significantly reduced fear-potentiated startle and increased punished responding in a modified Geller-Seifter conflict model consistent with an anxiolytic-like profile. MTEP decreased unpunished responding to a lesser extent than diazepam and had no effect on rotarod performance when administered either alone or in combination with ethanol. Repeated dosing with MTEP in this model eliminated the increase in punished responding observed with acute dosing.

References
Molecular Weight

236.72

Formula

C₁₁H₉ClN₂S

CAS No.

1186195-60-7

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
MTEP hydrochloride
Cat. No.:
HY-13206
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