2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. (RS)-MCPG

(RS)-MCPG  (Synonyms: alpha-MCPG)

Cat. No.: HY-100371 Purity: 99.05%
COA Handling Instructions

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.

For research use only. We do not sell to patients.

(RS)-MCPG Chemical Structure

(RS)-MCPG Chemical Structure

CAS No. : 146669-29-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 87 In-stock
Solution
10 mM * 1 mL in DMSO USD 87 In-stock
Solid
1 mg USD 38 In-stock
5 mg USD 80 In-stock
10 mg USD 110 In-stock
25 mg USD 240 In-stock
50 mg USD 430 In-stock
100 mg USD 780 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (RS)-MCPG:

(RS)-MCPG Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (RS)-MCPG

View All mGluR Isoform Specific Products:

View All Isoforms
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].

IC50 & Target[1]

mGluR

 

In Vitro

MCPG can block group I (mGluR1 and mGluR5) and group II receptors (mGluR2 and mGluR3)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(RS)-MCPG Related Antibodies
In Vivo

(RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[1].
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

209.20

Appearance

Solid

Formula

C10H11NO4
CAS No.
SMILES

CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

1M NaOH : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 10 with NaOH)

DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL
10 mM 0.4780 mL 2.3901 mL 4.7801 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: 99.05%

COA (249 KB) HNMR (246 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References
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(RS)-MCPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

(RS)-MCPG146669-29-6alpha-MCPGmGluRMetabotropic glutamate receptorsgroupI/IImetabotropicglutamatereceptorhippocampalneuronsmGluR1mGluR5mGluR2mGluR3Inhibitorinhibitorinhibit

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