(RS)-MCPG
Based on 1 publication(s) in Google Scholar
(RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.05%
- CAS 番号: 146669-29-6
- 分子式: C10H11NO4
- 分子量:209.20
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 (RS)-MCPG
More
生物活性
製品説明
IC50 & Target
[1]|
mGluR |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
700 μM
Compound: 3b
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Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
Compound was tested for inhibition of glutamate-evoked (10 uM) [Ca2+] mobilization in mGluR1-alpha expressed-CHO cells.
|
10.1016/0960-894X(96)00104-7 |
体外実験
体内実験
Pretreatment with the low dose of (RS)-MCPG (25 nM; i.c.; daily; 5 days) significantly attenuates amphetamine-induced locomotor activity in 10-day-old male and female rats of Sprague-Dawley descent[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 146669-29-6
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性状 Solid
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分子量 209.20
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分子式 C10H11NO4
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Color White to off-white
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SMILES
CC(C(O)=O)(N)C1=CC=C(C(O)=O)C=C1
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別名
alpha-MCPG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Front Cell Neurosci
Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis. [Abstract]2019 Jun 25:13:276. PMID: 31293391
溶剤 & 溶解度
体外:
1M NaOH : 100 mg/mL (478.01 mM; ultrasonic and adjust pH to 10 with NaOH)
DMSO : 6 mg/mL (28.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
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Primary Embryonic Hippocampal Neuron Culture
Primary embryonic hippocampal neuron culture is an in vitro method in which hippocampi from embryonic rodents are dissected, enzymatically or mechanically dissociated, plated on adhesive substrates, and maintained in defined neuronal medium or in low-density sandwich/co-culture formats to support neuronal attachment, neurite extension, polarity formation, dendritic arborization, and synapse formation. The main readouts are cell survival, neuronal purity, neurite outgrowth, axon-dendrite polarization, synaptic marker development, and functional neuronal activity, assessed by phase-contrast microscopy, immunocytochemistry for neuronal/glial markers, live imaging, or electrophysiology depending on the downstream experiment.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1M NaOH | 1 mM | 4.7801 mL | 23.9006 mL | 47.8011 mL | 119.5029 mL |
| 5 mM | 0.9560 mL | 4.7801 mL | 9.5602 mL | 23.9006 mL | |
| 10 mM | 0.4780 mL | 2.3901 mL | 4.7801 mL | 11.9503 mL | |
| 15 mM | 0.3187 mL | 1.5934 mL | 3.1867 mL | 7.9669 mL | |
| 20 mM | 0.2390 mL | 1.1950 mL | 2.3901 mL | 5.9751 mL | |
| 25 mM | 0.1912 mL | 0.9560 mL | 1.9120 mL | 4.7801 mL | |
| 1M NaOH | 30 mM | 0.1593 mL | 0.7967 mL | 1.5934 mL | 3.9834 mL |
| 40 mM | 0.1195 mL | 0.5975 mL | 1.1950 mL | 2.9876 mL | |
| 50 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3901 mL | |
| 60 mM | 0.0797 mL | 0.3983 mL | 0.7967 mL | 1.9917 mL | |
| 80 mM | 0.0598 mL | 0.2988 mL | 0.5975 mL | 1.4938 mL | |
| 100 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1950 mL |
(RS)-MCPG 関連分類
HY-100371 関連分類
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