1. GPCR/G Protein Neuronal Signaling
  2. mGluR
  3. (S)-MCPG

(S)-MCPG  (Synonyms: (+)-MCPG)

Cat. No.: HY-100406 Purity: 98.72%
COA Handling Instructions

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

For research use only. We do not sell to patients.

(S)-MCPG Chemical Structure

(S)-MCPG Chemical Structure

CAS No. : 150145-89-4

Size Price Stock Quantity
5 mg USD 79 In-stock
10 mg USD 106 In-stock
25 mg USD 238 In-stock
50 mg USD 436 In-stock
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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-MCPG:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE (S)-MCPG

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2].

IC50 & Target[1]



In Vitro

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo
Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze[2]
Dosage: 20 μg
Administration: Intraventricular injection; 20 μg; 4 days
Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
Molecular Weight









Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 22 mg/mL (105.16 mM; ultrasonic and adjust pH to 11 with NaOH)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM 0.9560 mL 4.7801 mL 9.5602 mL
10 mM 0.4780 mL 2.3901 mL 4.7801 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
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(S)-MCPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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