1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. (S)-MCPG

(S)-MCPG (Synonyms: (+)-MCPG)

Cat. No.: HY-100406 Purity: 98.80%
Handling Instructions

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371). (S)-MCPG can be used for the study of the function of mGluRs in spatial learning.

For research use only. We do not sell to patients.

(S)-MCPG Chemical Structure

(S)-MCPG Chemical Structure

CAS No. : 150145-89-4

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5 mg USD 72 In-stock
Estimated Time of Arrival: December 31
10 mg USD 96 In-stock
Estimated Time of Arrival: December 31
25 mg USD 216 In-stock
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50 mg USD 396 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

(S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2].

IC50 & Target[1]

mGluR

 

In Vitro

(S)-MCPG (100 μM) has no detectable effects on basal spine formation or elimination mechanisms in WT slice cultures. (S)-MCPG prevents the increase in spine turnover triggered by TBS and interferes with the mechanisms of activity-dependent spine stabilization in Hippocampal slice cultures[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

MCPG (intraventricular injection; 20 μg) treated rat are slower to learn the task and takes longer to reach the platform than vehicle injected animals. On days 2 and 3, MCPG rats has a significant longer escape latency and the measure of search error is significantly longer on each of the first 3 days. On day 4, MCPG-treated animals reaches the same level of performance as control animals in Morris water maze[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Lister-Hooded rats in the learning of the Morris water maze[2]
Dosage: 20 μg
Administration: Intraventricular injection; 20 μg; 4 days
Result: Impaired the performance of rats in the spatial version of the Morris water maze, but 1/10 of this dose did not.
Molecular Weight

209.20

Formula

C₁₀H₁₁NO₄

CAS No.

150145-89-4

SMILES

OC(C1=CC=C([[email protected]](C)(N)C(O)=O)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (4.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7801 mL 23.9006 mL 47.8011 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

(S)-MCPG(+)-MCPGmGluRMetabotropic glutamate receptorsabotropic receptorNMDA receptorsbehaviorlearning. memoryspatialfear metabotropicisomerInhibitorinhibitorinhibit

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(S)-MCPG
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HY-100406
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