1. GPCR/G Protein
    Neuronal Signaling
    NF-κB
    Stem Cell/Wnt
    MAPK/ERK Pathway
    PI3K/Akt/mTOR
  2. mGluR
    NF-κB
    ERK
    Akt
  3. CHPG sodium salt

CHPG sodium salt 

Cat. No.: HY-101364A
Handling Instructions

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways..

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CHPG sodium salt Chemical Structure

CHPG sodium salt Chemical Structure

CAS No. : 1303993-73-8

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Description

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].

IC50 & Target

mGlu5

 

NF-κB

 

ERK

 

Akt

 

In Vitro

CHPG sodium salt (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

Cell Viability Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10, 50, 100 and 500 µM
Incubation Time: 24 hours
Result: Increased the cell viability.

Apoptosis Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Protected BV2 cells against SO2-induced apoptosis.

Western Blot Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Increased the expression of TSG-6 in both mRNA and protein levels.
In Vivo

CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g[2]
Dosage: 250 nM
Administration: Injection; for 7 days
Result: Reduced significantly cerebral lesion volume.
Molecular Weight

223.59

Formula

C₈H₇ClNNaO₃

CAS No.

1303993-73-8

SMILES

O=C(O[Na])C(N)C1=CC(O)=CC=C1Cl

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CHPG sodium salt
Cat. No.:
HY-101364A
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