CHPG
Based on 4 publication(s) in Google Scholar
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.
For research use only. We do not sell to patients.
- Purity: 99.51%
- CAS No.: 170846-74-9
- Formula: C8H8ClNO3
- Molecular Weight:201.61
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CHPG
More
Biological Activity
|
mGlu5 |
NF-κB |
ERK |
CHPG (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BV2 microglial cells
-
Concentration:10, 50, 100 and 500 µM
-
Incubation Time:24 hours
-
Result:Increased the cell viability.
-
Cell Line:BV2 microglial cells
-
Concentration:0.5 mM
-
Incubation Time:30 mins
-
Result:Protected BV2 cells against SO2-induced apoptosis.
-
Cell Line:BV2 microglial cells
-
Concentration:0.5 mM
-
Incubation Time:30 mins
-
Result:Increased the expression of TSG-6 in both mRNA and protein levels.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Adult Sprague-Dawley male rats weighing 280-320 g[2]
-
Dosage:250 nM
-
Administration:Injection; for 7 days
-
Result:Reduced significantly cerebral lesion volume.
Chemical Information
-
CAS No. 170846-74-9
-
Appearance Solid
-
Molecular Weight 201.61
-
Formula C8H8ClNO3
-
Color White to off-white
-
SMILES
O=C(O)C(N)C1=CC(O)=CC=C1Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (4)
-
Journal Impact Factor
-
Most Recent
-
World J Gastroenterol
Inhibition of metabotropic glutamate receptor-5 alleviates hepatic steatosis by enhancing autophagy via activation of the AMPK signaling pathway. [Abstract]2025 Feb 21;31(7):98852. PMID: 39991675 -
Immunobiology
Liyan Kaiyin Formula relieves reflux pharyngitis by regulating M1 macrophage polarization via the NF-κB/NLRP3 pathway. [Abstract]2025 Jun 28;230(4):153095. PMID: 40602310 -
IBRO Neurosci Rep
CHPG's role in regulating apoptosis in heat-stressed microglia through endoplasmic reticulum stress: A new perspective☆. [Abstract]2025 May 26:18:823-829. PMID: 40520000 -
Solvent & Solubility
1M NaOH : 25 mg/mL (124.00 mM; ultrasonic and adjust pH to 11 with NaOH)
DMSO : 25 mg/mL (124.00 mM; ultrasonic and warming and adjust pH to 2 with 1 M HCl and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52. [Content Brief]
[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1M NaOH / DMSO | 1 mM | 4.9601 mL | 24.8005 mL | 49.6010 mL | 124.0024 mL |
| 5 mM | 0.9920 mL | 4.9601 mL | 9.9202 mL | 24.8005 mL | |
| 10 mM | 0.4960 mL | 2.4800 mL | 4.9601 mL | 12.4002 mL | |
| 15 mM | 0.3307 mL | 1.6534 mL | 3.3067 mL | 8.2668 mL | |
| 20 mM | 0.2480 mL | 1.2400 mL | 2.4800 mL | 6.2001 mL | |
| 25 mM | 0.1984 mL | 0.9920 mL | 1.9840 mL | 4.9601 mL | |
| 30 mM | 0.1653 mL | 0.8267 mL | 1.6534 mL | 4.1334 mL | |
| 40 mM | 0.1240 mL | 0.6200 mL | 1.2400 mL | 3.1001 mL | |
| 50 mM | 0.0992 mL | 0.4960 mL | 0.9920 mL | 2.4800 mL | |
| 60 mM | 0.0827 mL | 0.4133 mL | 0.8267 mL | 2.0667 mL | |
| 80 mM | 0.0620 mL | 0.3100 mL | 0.6200 mL | 1.5500 mL | |
| 100 mM | 0.0496 mL | 0.2480 mL | 0.4960 mL | 1.2400 mL |
CHPG Related Classifications
HY-101364 Related Classifications
Powered by Bioz