2. GPCR/G Protein Neuronal Signaling NF-κB MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR
  3. mGluR NF-κB ERK Akt
  4. CHPG

CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.

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CHPG Chemical Structure

CHPG Chemical Structure

CAS No. : 170846-74-9

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Based on 1 publication(s) in Google Scholar

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CHPG Related Antibodies

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Description

CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].

IC50 & Target

mGlu5

 

NF-κB

 

ERK

 

In Vitro

CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHPG Related Antibodies

Cell Viability Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10, 50, 100 and 500 µM
Incubation Time: 24 hours
Result: Increased the cell viability.

Apoptosis Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Protected BV2 cells against SO2-induced apoptosis.

Western Blot Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Increased the expression of TSG-6 in both mRNA and protein levels.
In Vivo

CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g[2]
Dosage: 250 nM
Administration: Injection; for 7 days
Result: Reduced significantly cerebral lesion volume.
Molecular Weight

201.61

Formula

C8H8ClNO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C(N)C1=CC(O)=CC=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

1M NaOH : 25 mg/mL (124.00 mM; ultrasonic and adjust pH to 11 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9601 mL 24.8004 mL 49.6007 mL
5 mM 0.9920 mL 4.9601 mL 9.9201 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: ≥99.0%

COA (247 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
1M NaOH 1 mM 4.9601 mL 24.8004 mL 49.6007 mL 124.0018 mL
5 mM 0.9920 mL 4.9601 mL 9.9201 mL 24.8004 mL
10 mM 0.4960 mL 2.4800 mL 4.9601 mL 12.4002 mL
15 mM 0.3307 mL 1.6534 mL 3.3067 mL 8.2668 mL
20 mM 0.2480 mL 1.2400 mL 2.4800 mL 6.2001 mL
25 mM 0.1984 mL 0.9920 mL 1.9840 mL 4.9601 mL
30 mM 0.1653 mL 0.8267 mL 1.6534 mL 4.1334 mL
40 mM 0.1240 mL 0.6200 mL 1.2400 mL 3.1000 mL
50 mM 0.0992 mL 0.4960 mL 0.9920 mL 2.4800 mL
60 mM 0.0827 mL 0.4133 mL 0.8267 mL 2.0667 mL
80 mM 0.0620 mL 0.3100 mL 0.6200 mL 1.5500 mL
100 mM 0.0496 mL 0.2480 mL 0.4960 mL 1.2400 mL
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CHPG Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHPG170846-74-9mGluRNF-κBERKAktMetabotropic glutamate receptorsNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesPKBProtein kinase BInhibitorinhibitorinhibit

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