1. GPCR/G Protein
    Neuronal Signaling
    NF-κB
    Stem Cell/Wnt
    MAPK/ERK Pathway
    PI3K/Akt/mTOR
  2. mGluR
    NF-κB
    ERK
    Akt
  3. CHPG

CHPG 

Cat. No.: HY-101364
Handling Instructions

CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.

For research use only. We do not sell to patients.

CHPG Chemical Structure

CHPG Chemical Structure

CAS No. : 170846-74-9

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Description

CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].

IC50 & Target[1,2]

mGluR5

 

NF-κB

 

ERK

 

Akt

 

In Vitro

CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1].
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1].
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

Cell Viability Assay[1]

Cell Line: BV2 microglial cells
Concentration: 10, 50, 100 and 500 µM
Incubation Time: 24 hours
Result: Increased the cell viability.

Apoptosis Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Protected BV2 cells against SO2-induced apoptosis.

Western Blot Analysis[1]

Cell Line: BV2 microglial cells
Concentration: 0.5 mM
Incubation Time: 30 mins
Result: Increased the expression of TSG-6 in both mRNA and protein levels.
In Vivo

CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

Animal Model: Adult Sprague-Dawley male rats weighing 280-320 g[2]
Dosage: 250 nM
Administration: Injection; for 7 days
Result: Reduced significantly cerebral lesion volume.
Molecular Weight

201.61

Formula

C₈H₈ClNO₃

CAS No.

170846-74-9

SMILES

O=C(O)C(N)C1=CC(O)=CC=C1Cl

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CHPG
Cat. No.:
HY-101364
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