170846-74-9
170846-74-9
Chemical Structure
CHPG
- CAS No.: 170846-74-9
- Formula:C8H8ClNO3
- Molecular Weight:201.61
IUPAC Name: 2-amino-2-(2-chloro-5-hydroxyphenyl)acetic acid
InChIKey: UNIDAFCQFPGYJJ-UHFFFAOYSA-N
SMILES: O=C(O)C(N)C1=CC(O)=CC=C1Cl
Biological Activity: CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CHPG | 99.66% | CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. | ||||||||||||||||||||
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References
- [1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52. [Content Brief]
- [2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6. [Content Brief]
