1303993-73-8
1303993-73-8
Chemical Structure
CHPG sodium salt
- CAS No.: 1303993-73-8
- Formula:C8H7ClNNaO3
- Molecular Weight:223.59
IUPAC Name: sodium 2-amino-2-(2-chloro-5-hydroxyphenyl)acetate
InChIKey: KZRZZIISUUINJT-UHFFFAOYSA-M
SMILES: O=C(O[Na])C(N)C1=CC(O)=CC=C1Cl
Biological Activity: CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CHPG sodium salt | 99.57% | CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.. | ||||||||||||||||||||
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CHPG sodium salt (Standard) | ≥98% | CHPG (sodium salt) (Standard) is the analytical standard of CHPG (sodium salt). This product is intended for research and analytical applications. CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.. | ||||||||||||||||||||
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References
- [1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52. [Content Brief]
- [2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6. [Content Brief]
