1246816-71-6
Chemical Structure
4-Hydroperoxy Cyclophosphamide-d4
- CAS No.: 1246816-71-6
- Formula:C7H11D4Cl2N2O4P
- Molecular Weight:297.11
IUPAC Name: 2-(bis(2-chloroethyl-2,2-d2)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide
InChIKey: VPAWVRUHMJVRHU-RRVWJQJTSA-N
SMILES: N(CC(Cl)([2H])[2H])(CC(Cl)([2H])[2H])P1(=O)NC(OO)CCO1
Biological Activity: 4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders[1][2].
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4-Hydroperoxy Cyclophosphamide-d4 | 95.0% | 4-Hydroperoxy Cyclophosphamide-d4 is the deuterium labeled 4-Hydroperoxy cyclophosphamide. 4-Hydroperoxy cyclophosphamide is the active metabolite form of the proagent Cyclophosphamide. 4-Hydroperoxy cyclophosphamide crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide has the potential for lymphomas and autoimmune disorders. | ||||||||||||||||||||
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4-Hydroperoxy cyclophosphamide | 98.0% | 4-Hydroperoxy cyclophosphamide is the active metabolite form of the precursor Cyclophosphamide. 4-Hydroperoxy cyclophosphamide cross-links DNA to induce T cell apoptosis independent of caspase receptor activation, and can activate the mitochondrial death pathway by producing reactive oxygen species (ROS). 4-Hydroperoxy cyclophosphamide can be used in the study of rheumatoid arthritis and autoimmune diseases. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG [Content Brief]
