1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker
  3. N-Nitroso-N-methylurea

N-Nitroso-N-methylurea (Synonyms: NMU; MNU; NMH)

Cat. No.: HY-34758 Purity: >98.0%
Handling Instructions

N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.

For research use only. We do not sell to patients.

N-Nitroso-N-methylurea Chemical Structure

N-Nitroso-N-methylurea Chemical Structure

CAS No. : 684-93-5

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Based on 1 publication(s) in Google Scholar

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Description

N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane[1][2][3][4].

In Vitro

N-Nitroso-N-methylurea (NMU; 5 μM) treatment increases the cellular NF-κB activity in human malignant keratinocytes. N-Nitroso-N-methylurea also increases the amount of I-κBα phosphorylation[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

N-Nitroso-N-methylurea (NMU) gives intravenously to rats at age 50 days induced mammary carcinomas in 89% of BUF/N, 73% of Sprague-Dawley, and 89% of F344 females. Latent periods are, respectively, 77, 86, and 94 days. Doubling times of NMU-induced primary and transplanted carcinomas are similar to 7 days. Cachexia ensues at the 5th week from the onset of the first tumor. When the tumor is larger than 15 g, hypercalcemia is usually observed[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

103.08

Formula

C₂H₅N₃O₂

CAS No.

684-93-5

SMILES

O=C(N)N(C)N=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (1212.65 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7012 mL 48.5060 mL 97.0120 mL
5 mM 1.9402 mL 9.7012 mL 19.4024 mL
10 mM 0.9701 mL 4.8506 mL 9.7012 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (20.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (20.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (20.18 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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Keywords:

N-Nitroso-N-methylureaNMU MNU NMHDNA Alkylator/CrosslinkerCarcinogenmutagenteratogenandalkylatingpro-tumorprecursordiazomethaneInhibitorinhibitorinhibit

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N-Nitroso-N-methylurea
Cat. No.:
HY-34758
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