1. Membrane Transporter/Ion Channel
    GPCR/G Protein
    Neuronal Signaling
    Autophagy
  2. P2X Receptor
    5-HT Receptor
    Autophagy
  3. Indophagolin

Indophagolin 

Cat. No.: HY-134807 Purity: 98.05%
Handling Instructions

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.

For research use only. We do not sell to patients.

Indophagolin Chemical Structure

Indophagolin Chemical Structure

CAS No. : 1207660-00-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 346 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 346 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

IC50 & Target[1]

P2X1

2.4 μM (IC50)

P2X4

2.71 μM (IC50)

P2Y11

3.4 μM (IC50)

P2X3

3.49 μM (IC50)

P2Y4

4.89 μM (IC50)

P2Y6

15.4 μM (IC50)

Autophagy

140 nM (IC50)

5-HT6 Receptor

1.0 μM (IC50)

In Vitro

Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

523.75

Formula

C₁₉H₁₅BrClF₃N₂O₃S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (477.33 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9093 mL 9.5465 mL 19.0931 mL
5 mM 0.3819 mL 1.9093 mL 3.8186 mL
10 mM 0.1909 mL 0.9547 mL 1.9093 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (3.97 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.97 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Indophagolin
Cat. No.:
HY-134807
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