1. Membrane Transporter/Ion Channel
    Autophagy
  2. P2X Receptor
    Autophagy
  3. Indophagolin

Indophagolin 

Cat. No.: HY-134807
Handling Instructions

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7.

For research use only. We do not sell to patients.

Indophagolin Chemical Structure

Indophagolin Chemical Structure

CAS No. : 1207660-00-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 346 In-stock
Estimated Time of Arrival: December 31
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 480 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
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50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

In Vitro

Indophagolin (10 μM) inhibits autophagosome formation in MCF7 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

523.75

Formula

C₁₉H₁₅BrClF₃N₂O₃S

CAS No.

1207660-00-1

SMILES

O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

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Keywords:

IndophagolinP2X ReceptorAutophagyP2XRsautophagosomeformationindoline-basedclassmembrane-boundInhibitorinhibitorinhibit

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