2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. 5-HT Receptor Histamine Receptor Adrenergic Receptor
  4. AVN-101 hydrochloride

AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56  nM, and 1.17  nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis.

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AVN-101 hydrochloride Chemical Structure

AVN-101 hydrochloride Chemical Structure

CAS No. : 1061354-48-0

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AVN-101 hydrochloride Related Antibodies

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Description

AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56  nM, and 1.17  nM, respectively). AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, and multiple sclerosis[1].

IC50 & Target[1]

5-HT7 Receptor

0.153 nM (Ki)

5-HT2C Receptor

1.17 nM (Ki)

5-HT2A Receptor

1.56 nM (Ki)

5-HT6 Receptor

2.04 nM (Ki)

5-HT2B Receptor

10.6 nM (Ki)

5-HT1A Receptor

61 nM (Ki)

5-HT1B Receptor

720 nM (Ki)

H1 Receptor

0.58 nM (Ki)

Alpha-2B adrenergic receptor

0.41 nM (Ki)

Alpha-2A adrenergic receptor

1.77 nM (Ki)

Alpha-2C adrenergic receptor

3.55 nM (Ki)

Alpha-1B adrenergic receptor

9.4 nM (Ki)

Alpha-1A adrenergic receptor

18.9 nM (Ki)

Alpha-1D adrenergic receptor

30.2 nM (Ki)

Molecular Weight

340.89

Formula

C21H25ClN2
CAS No.
SMILES

CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AVN-101 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AVN-1011061354-48-0AVN101AVN 1015-HT ReceptorHistamine ReceptorAdrenergic ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptoranxiolytic and anti-depressive activitiescentral nervous system (CNS) diseases5-HT7 receptorhistamine H1brain-penetrantorally activeInhibitorinhibitorinhibit

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